What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
Citations
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Activation of the G-protein coupled receptor GPR35 by human milk oligosaccharides through different pathways.
TL;DR: A remarkable cooperation between nutrition and microbiota towards activation of a host receptor highlighting the close interplay between environment and host-microbe interactions is demonstrated.
Journal ArticleDOI
How far is it from infant formula to human milk? A look at the human milk oligosaccharides
TL;DR: In this article, the authors summarized the structures and composition of HMOs, and compared the differences of oligosaccharides in human and other mammals, and discussed existing studies on the functional biology and structure-function relationships of the HMO.
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Associations between human milk oligosaccharides (HMOs) and eating behaviour in Hispanic infants at 1 and 6 months of age.
Jasmine F. Plows,Paige K. Berger,Roshonda B. Jones,Chloe Yonemitsu,Ji H. Ryoo,Tanya L. Alderete,Lars Bode,Michael I. Goran +7 more
TL;DR: Human milk oligosaccharides are naturally occurring glycans in human breast milk that act as prebiotics in the infant gut that may affect infant eating behaviour.
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Does the contribution of human milk oligosaccharides to the beneficial effects of breast milk allow us to hope for an improvement in infant formulas
TL;DR: Better understanding of the role of HMOs leading to the development of inexpensive methods for large-scale HMO production is needed, and randomized controlled trials are restricted to structurally simple compounds such as 2’ fucosyllactose and lacto-N-neotetraose.
Journal ArticleDOI
High-Throughput Glycomic Methods
Irena Trbojević-Akmačić,Guinevere S. M. Lageveen-Kammeijer,Bram Heijs,Tea Petrović,Helena Deriš,Manfred Wuhrer,Gordan Lauc +6 more
TL;DR: The current state-of-the-art regarding levels of characterization and most widely used technologies, selected applications of high-throughput glycomics in deciphering glycosylation process in healthy and disease states, as well as future perspectives are described.
References
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