What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
Citations
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The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
Christian Milani,Sabrina Duranti,Francesca Bottacini,Eoghan Casey,Francesca Turroni,Jennifer Mahony,Clara Belzer,Susana Delgado Palacio,Silvia Arboleya Montes,Leonardo Mancabelli,Gabriele Andrea Lugli,Juan M. Rodríguez,Lars Bode,Willem M. de Vos,Willem M. de Vos,Miguel Gueimonde,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +18 more
TL;DR: The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.
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Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors
Shirin Moossavi,Shadi Sepehri,Bianca Robertson,Lars Bode,Susan Goruk,Catherine J. Field,Lisa M. Lix,Russell J. de Souza,Russell J. de Souza,Russell J. de Souza,Allan B. Becker,Piushkumar J. Mandhane,Stuart E. Turvey,Padmaja Subbarao,Theo J. Moraes,Diana L. Lefebvre,Malcolm R. Sears,Ehsan Khafipour,Ehsan Khafipour,Meghan B. Azad +19 more
TL;DR: Providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria, which support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota.
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Rapid changes in Atlantic grey seal milk from birth to weaning - immune factors and indicators of metabolic strain.
Amanda D. Lowe,Sami Bawazeer,David G. Watson,Suzanne McGill,Richard Burchmore,Patrick Pomeroy,Martyn Kennedy +6 more
TL;DR: There was an unexpected persistence of immunoglobulin G almost until weaning, potentially indicating prolonged trans-intestinal transfer of IgG and among components of innate immune protection were found fucosyllactose and siallylactose that are thought to impede colonisation by pathogens and encourage an appropriate milk-digestive and protective gut microbiome.
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Human Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) and Lacto-N-Neotetraose (LNnT) in Infant Formula
Yvan Vandenplas,Bernard Berger,Virgilio P. Carnielli,Janusz Ksiazyk,Hanna Lagström,Manuel Sánchez Luna,N.B. Migacheva,Jean-Marc Mosselmans,Jean-Charles Picaud,Mike Possner,Atul Singhal,Martin Wabitsch +11 more
TL;DR: The limited clinical data suggest that the addition of HMOs to infant formula seems to be safe and well tolerated, inducing a normal growth and suggesting a trend towards health benefits.
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Human Milk Oligosaccharide Concentrations Are Associated with Multiple Fixed and Modifiable Maternal Characteristics, Environmental Factors, and Feeding Practices.
Meghan B. Azad,Meghan B. Azad,Bianca Robertson,Faisal Atakora,Allan B. Becker,Padmaja Subbarao,Theo J. Moraes,Piushkumar J. Mandhane,Stuart E. Turvey,Diana L. Lefebvre,Malcolm R. Sears,Lars Bode +11 more
TL;DR: HMO concentrations vary widely between mothers and are associated with multiple characteristics beyond genetic Secretor status, as well as feeding practices and environmental factors, which are warranted to determine how these associations affect infant health.
References
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Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding
Lars Bode,Louise Kuhn,Hae-Young Kim,Lauren Hsiao,Caroline Nissan,Moses Sinkala,Chipepo Kankasa,Mwiya Mwiya,Donald M. Thea,Grace M. Aldrovandi +9 more
TL;DR: Higher concentrations of non-3'-SL HMOs were associated with protection against postnatal HIV transmission independent of other known risk factors, and these novel, potentially anti-HIV components of breast milk are warranted.
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Simultaneous quantification of sialyloligosaccharides from human milk by capillary electrophoresis
TL;DR: The novel method described here uses a running buffer of aqueous 200mM NaH2PO4 (pH 7.05) containing 100mM sodium dodecyl sulfate (SDS) mixed with 45% (v/v) methanol to baseline resolve 5 oligosaccharides and allows automated simultaneous quantification of the 12 major sialyloligosac charides of human milk in a single 35-min run.
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Human Milk Contains Elements That Block Binding of Noroviruses to Human Histo—Blood Group Antigens in Saliva
Xi Jiang,Pengwei Huang,Weiming Zhong,Ming Tan,Tibor Farkas,Ardythe L. Morrow,David S. Newburg,Guillermo M. Ruiz-Palacios,Larry K. Pickering +8 more
TL;DR: Secretor and Lewis, but not A or B antigens, were present in human milk and were responsible for blocking NV binding to receptors and therefore are likely to be decoy receptors that protect breast-fed infants from NV infection.
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Structure-Function Analysis of Human 1,3-Fucosyltransferase AMINO ACIDS INVOLVED IN ACCEPTOR SUBSTRATE SPECIFICITY
TL;DR: Results obtained from domain swapping experiments demonstrated that the single amino acid sequence difference near the C terminus of these enzymes did not alter the enzyme's substrate specificity, however, swapping a region near the N termini of the truncated form of FucT III into an homologous region in Fuc T V produced a protein with both alpha1,3- andalpha1,4-fucosyltransferase activity.
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Human Milk Oligosaccharides Protect Against Enteropathogenic Escherichia coli Attachment In Vitro and EPEC Colonization in Suckling Mice
TL;DR: An essential role for HMOs is suggested in the prevention of EPEC infections in human infants as a result of human milk oligosaccharides present in human milk but not in infant formula.