What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
Citations
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Systematic Characterization and Longitudinal Study Reveal Distinguishing Features of Human Milk Oligosaccharides in China.
TL;DR: Dynamic changes of 24 HMOs in secretors and nonsecretors during lactation revealed unique features of these HMO profiles in the milk of Chinese mothers and Interestingly, 2′-FL concentrations insecretors were found to be lower than those of Western populations but higher than those in African populations.
Journal ArticleDOI
Human Milk Oligosaccharide Profiles and Associations with Maternal Nutritional Factors: A Scoping Review
Caren Biddulph,Mark A. Holmes,Anna Kuballa,Peter Davies,Pieter Koorts,Roger Jaffrey Carter,Judith Maher +6 more
TL;DR: In this article, the authors examined current knowledge of the effect of maternal diet and nutritional status on the composition of human milk oligosaccharides (HMOs) in breast milk, using the PRISMA-ScR guidelines, a comprehensive, systematic literature search was conducted using Scopus, Web of Science, Global Health (CABI), and MEDLINE.
Journal ArticleDOI
Variation Among Populations in the Immune Protein Composition of Mother's Milk Reflects Subsistence Pattern
Laura D Klein,Jincui Huang,Elizabeth A. Quinn,Melanie Martin,Alicia A. Breakey,Michael Gurven,Hillard Kaplan,Claudia Valeggia,Grazyna Jasienska,Brooke A. Scelza,Carlito B. Lebrilla,Katie Hinde,Katie Hinde +12 more
TL;DR: The results suggest that the immune defenses in milk are shaped by a mother’s environment throughout her life, and fundamental variation in milk composition that has not been previously explored in human milk research is revealed.
Journal ArticleDOI
Diversification of a Fucosyllactose Transporter within the Genus <i>Bifidobacterium</i>
TL;DR: Human milk oligosaccharides from breast milk selectively promote the growth of specific taxa such as bifidobacteria, thus forming an HMO-mediated host-microbe symbiosis as discussed by the authors .
Posted ContentDOI
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration
Benjamin P. Kellman,Anne Richelle,Jeong-Yeh Yang,Digantkumar Chapla,Austin W. T. Chiang,Austin W. T. Chiang,Julia A Najera,Bokan Bao,Natalia Koga,Mahmoud A. Mohammad,Anders Bech Bruntse,Morey W. Haymond,Kelley W. Moremen,Lars Bode,Nathan E. Lewis,Nathan E. Lewis +15 more
TL;DR: A systems biology framework was used that integrated glycan and RNA expression data to construct an HMO biosynthetic network and predict glycosyltransferases involved and proposed candidate genes for elongation, branching, fucosylation, and sialylation of HMOs.
References
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