What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
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Maternal and Infant Factors Influencing Human Milk Oligosaccharide Composition: Beyond Maternal Genetics
Soo Min Han,José G. B. Derraik,José G. B. Derraik,José G. B. Derraik,Aristea Binia,Norbert Sprenger,Mark H. Vickers,Wayne S. Cutfield +7 more
TL;DR: A systematic search was performed on PubMed and Web of Science (without a time restriction) to identify any relevant studies published as mentioned in this paper, of which 29 articles were selected to be included in this review.
Journal ArticleDOI
Safety evaluation of 3'-siallylactose sodium salt supplementation on growth and clinical parameters in neonatal piglets.
TL;DR: Supporting evidence is provided for the safety of supplementation of this enzymatically‐synthesized 3′SL sodium salt to human infant formula with well‐tolerated by neonatal piglets and supported growth and development comparable to those observed in the CON group.
Journal ArticleDOI
Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multi-omics integration
TL;DR: In this article , the authors used a system biology framework that integrates glycan and RNA expression data to construct an HMO biosynthetic network and predict glycosyltransferases involved.
Journal ArticleDOI
2'-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway.
TL;DR: 2'-FL ameliorates IMQ-induced psoriasis by inhibiting Th17 cell immune response and Th17-related cytokine secretion via modulation of the STAT3 signaling pathway, as well as reducing the phosphorylation of STAT3 in the skin tissue from mice with IMQ stimulation.
Journal ArticleDOI
Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants
Victor D Torres Roldan,Meritxell Urtecho S,Julia Gupta,Chloe Yonemitsu,Cesar Carcamo,Lars Bode,Theresa J. Ochoa,Theresa J. Ochoa +7 more
TL;DR: The findings suggest that concentrations of different HMOs vary from one individual to another according to their lactation period and secretor status, and that FDSLNH might protect infants with very low birth weight from late-onset neonatal sepsis.
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