What’s normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically
Michelle K. McGuire,Courtney L. Meehan,Mark A. McGuire,Janet E. Williams,James A. Foster,Daniel W. Sellen,Elizabeth W. Kamau-Mbuthia,Egidioh W. Kamundia,Samwel Mbugua,Sophie E. Moore,Andrew M. Prentice,Linda J. Kvist,Gloria E. Otoo,Sarah L Brooker,William J. Price,Bahman Shafii,Caitlyn D. Placek,Kimberly A. Lackey,Bianca Robertson,Susana Manzano,Lorena Ruiz,Juan M. Rodríguez,Rossina G. Pareja,Lars Bode +23 more
TLDR
The hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women is supported and targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2017-05-01 and is currently open access. It has received 263 citations till now. The article focuses on the topics: Postpartum period.read more
Citations
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Architecture Insight of Bifidobacterial α-L-Fucosidases.
José Antonio Curiel,Ángela Peirotén,José María Landete,Ana Ruiz de la Bastida,Susana Langa,Juan L. Arqués +5 more
TL;DR: This work reveals four and two paralogue bifidobacterial fucosidase groups within GH29 and GH95 families, respectively, and indicates the possibility of their application to transfucosylate substrates other than lactose in order to synthesis novel prebiotics.
Journal ArticleDOI
Safety of 6′‐sialyllactose (6’‐SL) sodium salt produced by derivative strains of Escherichia coli BL21 (DE3) as a novel food pursuant to Regulation (EU) 2015/2283
Dominique Turck,Torsten Bohn,J.J.M. Castenmiller,Stefaan De Henauw,Karen I. Hirsch-Ernst,Alexandre Maciuk,Inge Mangelsdorf,Harry J. McArdle,Androniki Naska,Carmen Peláez,Kristina Pentieva,Alfonso Siani,Frank Thies,Sophia Tsabouri,Marco Vinceti,Francesco Cubadda,Thomas Frenzel,Marina Heinonen,Rosangela Marchelli,Monika Neuhäuser-Berthold,Morten Poulsen,Miguel Prieto Maradona,Josef Rudolf Schlatter,Henk Van Loveren,Paolo Colombo,Estefania Noriega Fernandez,Helle Katrine Knutsen +26 more
TL;DR: In this paper , the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on 6'Sialyllactose (6'SL) sodium salt as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
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Pregnancy-Related Diseases and Delivery Mode can Affect the Content of Human Milk Oligosaccharides: A Preliminary Study.
Xiaoqin Wang,Jing Li,Cheng Li,Yifan Xu,Xinyi Wang,Yu Lu,Ting Zhang,Hongzhi Cao,Lina Huang,Zhongfu Wang +9 more
TL;DR: Colostrum from mothers with pregnancy-induced hypertension had higher levels of fucosylated oligosaccharides, but the difference was not significant, and hypothyroidism appeared to have no effect on HMOs, which were more abundant from mothers who underwent vaginal delivery than a C-section.
Journal ArticleDOI
Development of high-throughput UPLC-MS/MS using multiple reaction monitoring for quantitation of complex human milk oligosaccharides and application to large population survey of secretor status and Lewis blood group.
Jiaqi Li,Ye Bi,Yi Zheng,Cuiyan Cao,Long Yu,Zhenyu Yang,Wengang Chai,Jingyu Yan,Jianqiang Lai,Xinmiao Liang +9 more
TL;DR: In this paper , the authors used UPLC-MS-MRM in the negative-ion mode for accurate quantification of 23 complex HMOs in just 15 min and selected oligosaccharides are in their native forms and include neutral and sialylated, fucosylated and non-fucosylated, linear and branching, and secretor and Lewis phenotype indicators.
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