XRN 5'→3' exoribonucleases: structure, mechanisms and functions.
TLDR
Current knowledge of XRNs is reviewed, highlighting recent work of high impact and future potential and the breakthrough in the understanding of how XRN1 processively degrades 5' monophosphorylated RNA is revealed by its crystal structure and mutational analysis.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-06-01 and is currently open access. It has received 298 citations till now. The article focuses on the topics: Small RNA & Exoribonuclease.read more
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Cytoplasmic 5 -3 exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Daniel A. Medina,Antonio Jordán-Pla,Gonzalo Millán-Zambrano,Sebastián Chávez,Mordechai Choder,José E. Pérez-Ortín +5 more
TL;DR: This work shows that disruption of Xrn1 activity preferentially affects both the synthesis and decay of a distinct subpopulation of mRNAs, and proposes to name the most affected genes “Xrn1 synthegradon.”
Journal ArticleDOI
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis.
Phillip J. Hsu,Yunfei Zhu,Honghui Ma,Honghui Ma,Yueshuai Guo,Xiaodan Shi,Yuanyuan Liu,Meijie Qi,Zhike Lu,Zhike Lu,Hailing Shi,Hailing Shi,Jianying Wang,Yiwei Cheng,Guan-Zheng Luo,Guan-Zheng Luo,Qing Dai,Qing Dai,Mingxi Liu,Xuejiang Guo,Jiahao Sha,Bin Shen,Chuan He,Chuan He +23 more
TL;DR: YTHDC2 is an m6A-binding protein that plays critical roles during spermatogenesis and enhances the translation efficiency of its targets and also decreases their mRNA abundance.
Journal ArticleDOI
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics
TL;DR: During recovery, RNA metabolism, posttranscriptional gene silencing, and RNA-directed DNA methylation have the potential to play key roles in resetting the epigenome and transcriptome and in altering memory.
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Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis
Mengji Cao,Peng Du,Xian-Bing Wang,Yun-Qi Yu,Yan-Hong Qiu,Wan-Xiang Li,Amit Gal-On,Changyong Zhou,Yi Li,Shou-Wei Ding +9 more
TL;DR: It is proposed that antiviral RNAi activates broad-spectrum antiviral activity via widespread silencing of host genes directed by vasiRNAs in addition to specific antiviral defense by viral siRNAs.
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Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes
Søren Lykke-Andersen,Yun Chen,Britt R. Ardal,Berit Lilje,Johannes Waage,Albin Sandelin,Torben Heick Jensen +6 more
TL;DR: It is hypothesized that snoRNA host genes need to be highly transcribed to accommodate high levels of sno RNA production and that the expression of individual snoRNAs and their cognate spliced RNA can be uncoupled via alternative splicing and NMD.
References
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