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Showing papers on "Proton published in 2006"


Journal ArticleDOI
TL;DR: Intensity-modulated radiation therapy (IMRT) allows dose to be concentrated in the tumor volume while sparing normal tissues, however, the downside to IMRT is the potential to increase the number of radiation-induced second cancers, so that doubling it may not be acceptable in older patients and in children.
Abstract: Intensity-modulated radiation therapy (IMRT) allows dose to be concentrated in the tumor volume while sparing normal tissues. However, the downside to IMRT is the potential to increase the number of radiation-induced second cancers. The reasons for this potential are more monitor units and, therefore, a larger total-body dose because of leakage radiation and, because IMRT involves more fields, a bigger volume of normal tissue is exposed to lower radiation doses. Intensity-modulated radiation therapy may double the incidence of solid cancers in long-term survivors. This outcome may be acceptable in older patients if balanced by an improvement in local tumor control and reduced acute toxicity. On the other hand, the incidence of second cancers is much higher in children, so that doubling it may not be acceptable. IMRT represents a special case for children for three reasons. First, children are more sensitive to radiation-induced cancer than are adults. Second, radiation scattered from the treatment volume is more important in the small body of the child. Third, the question of genetic susceptibility arises because many childhood cancers involve a germline mutation. The levels of leakage radiation in current Linacs are not inevitable. Leakage can be reduced but at substantial cost. An alternative strategy is to replace X-rays with protons. However, this change is only an advantage if the proton machine employs a pencil scanning beam. Many proton facilities use passive modulation to produce a field of sufficient size, but the use of a scattering foil produces neutrons, which results in an effective dose to the patient higher than that characteristic of IMRT. The benefit of protons is only achieved if a scanning beam is used in which the doses are 10 times lower than with IMRT.

1,040 citations


Journal ArticleDOI
TL;DR: In this article, the authors presented new parameterizations of energy spectra of secondary particles, including mesons, gamma rays, electrons, and neutrinos produced in inelastic proton-proton collisions.
Abstract: We present new parameterizations of energy spectra of secondary particles, $\ensuremath{\pi}$ mesons, gamma rays, electrons, and neutrinos produced in inelastic proton-proton collisions. The simple analytical approximations based on simulations of proton-proton interactions using the public available SIBYLL code provide very good accuracy for energy distributions of secondary products in the energy range above 100 GeV. Generally, the recommended analytical formulas deviate from the simulated distributions within a few percent over a large range of $x={E}_{i}/{E}_{p}$---the fraction of energy of the incident proton transferred to the secondaries. Finally, we describe an approximate procedure of continuation of calculations towards low energies, down to the threshold of $\ensuremath{\pi}$-meson production.

767 citations


Journal ArticleDOI
TL;DR: In this article, a comparison between WIND/SWE observations (Kasper et al., 2006) of beta parallel to p and T perpendicular to p/T parallel to P (where beta is the proton parallel beta and T is the perpendicular and parallel proton are the parallel and proton temperatures, respectively) and predictions of the Vlasov linear theory is presented.
Abstract: We present a comparison between WIND/SWE observations (Kasper et al., 2006) of beta parallel to p and T perpendicular to p/T parallel to p (where beta parallel to p is the proton parallel beta and T perpendicular to p and T parallel to p are the perpendicular and parallel proton are the perpendicular and parallel proton temperatures, respectively; here parallel and perpendicular indicate directions with respect to the ambient magnetic field) and predictions of the Vlasov linear theory. In the slow solar wind, the observed proton temperature anisotropy seems to be constrained by oblique instabilities, by the mirror one and the oblique fire hose, contrary to the results of the linear theory which predicts a dominance of the proton cyclotron instability and the parallel fire hose. The fast solar wind core protons exhibit an anticorrelation between beta parallel to c and T perpendicular to c/T parallel to c (where beta parallel to c is the core proton parallel beta and T perpendicular to c and T parallel to c are the perpendicular and parallel core proton temperatures, respectively) similar to that observed in the HELIOS data (Marsch et al., 2004).

465 citations


Journal ArticleDOI
TL;DR: In this article, acceptor-doped rare earth ortho-niobates and ortho tantalates, RE1−xAxMO4 (M=Nb,Ta) were investigated and shown to have mixed protonic, native ionic and electronic conduction depending on conditions.
Abstract: Some oxides contain sufficient equilibrium concentrations of protons in wet atmospheres to show useful proton conduction at elevated temperatures1. As an example, Y-doped BaCeO3 has shown promising performance as a thin-film electrolyte in fuel cells at intermediate temperatures (400–600 ∘C)2. In contrast to proton-conducting polymers (for example, Nafion(R)) and acid salts (for example, CsHSO4), such oxidic ceramics are stable at sufficiently elevated temperatures that electrode kinetics are fast and insensitive to poisoning, but they tend to be basic (Ba-based or Sr-based) compounds with poor chemical and mechanical stability3. In search of more stable proton-conducting materials, we have investigated several acceptor-doped rare-earth ortho-niobates and ortho-tantalates, RE1−xAxMO4 (M=Nb,Ta). We show that this class of materials shows mixed protonic, native ionic and electronic conduction depending on conditions. Both the low-temperature monoclinic and high-temperature tetragonal polymorphs show proton conduction. The proton conductivity is dominant in wet atmospheres below roughly 800∘C and the highest proton conductivity of approximately 10−3Scm−1 was found for Ca-doped LaNbO4. These transport characteristics can be used in sensors and fuel cells provided that the electrolyte film thickness is in the micrometre range.

441 citations


Journal ArticleDOI
14 Apr 2006-Science
TL;DR: It is shown that, in this enzyme system, tunneling is promoted by a short-range motion modulating proton-acceptor distance and no long-range coupled motion is required.
Abstract: We present an atomic-level description of the reaction chemistry of an enzyme-catalyzed reaction dominated by proton tunneling. By solving structures of reaction intermediates at near-atomic resolution, we have identified the reaction pathway for tryptamine oxidation by aromatic amine dehydrogenase. Combining experiment and computer simulation, we show proton transfer occurs predominantly to oxygen O2 of Asp(128)beta in a reaction dominated by tunneling over approximately 0.6 angstroms. The role of long-range coupled motions in promoting tunneling is controversial. We show that, in this enzyme system, tunneling is promoted by a short-range motion modulating proton-acceptor distance and no long-range coupled motion is required.

291 citations


Journal ArticleDOI
TL;DR: While spectral resolution continues to increase with field strength, the absolute signal‐to‐noise ratio (SNR) in T1/T2‐based anatomical MRI quickly levels off beyond ∼7 T and may actually decrease at higher magnetic fields.
Abstract: Comprehensive and quantitative measurements of T1 and T2 relaxation times of water, metabolites, and macromolecules in rat brain under similar experimental conditions at three high magnetic field strengths (4.0 T, 9.4 T, and 11.7 T) are presented. Water relaxation showed a highly significant increase (T1) and decrease (T2) with increasing field strength for all nine analyzed brain structures. Similar but less pronounced effects were observed for all metabolites. Macromolecules displayed field-independent T2 relaxation and a strong increase of T1 with field strength. Among other features, these data show that while spectral resolution continues to increase with field strength, the absolute signal-to-noise ratio (SNR) in T1/T2-based anatomical MRI quickly levels off beyond approximately 7 T and may actually decrease at higher magnetic fields.

286 citations


Journal ArticleDOI
TL;DR: In this article, a joint study of the electrons diffusion and advection in the downstream medium of the supernova shock was carried out, and it was shown that the magnetic field must be amplified up to values between 250 and 500 µG in the case of Cas A, Kepler, and Tycho, or ∼100 µ Gi n in case of SN 1006 and G347.
Abstract: Constraints on the diffusion and acceleration parameters in five young supernova remnants (SNRs) are derived from the observed thickness of their X-ray rims, as limited by the synchrotron losses of the highest energy electrons, assuming uniform and isotropic turbulence. From a joint study of the electrons diffusion and advection in the downstream medium of the shock, it is shown that the magnetic field must be amplified up to values between 250 and 500 µG in the case of Cas A, Kepler, and Tycho, or ∼100 µ Gi n the case of SN 1006 and G347.3-0.5. The diffusion coefficient at the highest electron energy can also be derived from the data, by relating the X-ray energy cutoff to the acceleration timescale. Values typically between 1 and 10 times the Bohm diffusion coefficient are found to be required. We also find interesting constraints on the energy dependence of the diffusion coefficient, by requiring that the diffusion coefficient at the maximum proton energy be not smaller than the Bohm value in the amplified field. This favours diffusion regime between the Kraichnan and the Bohm regime, and rejects turbulence spectrum indices larger than � 3/2. Finally, the maximum energy of the accelerated particles is found to lay between 10 13 and 5 × 10 13 eV for electrons, and around Z × 8 × 10 14 eV at most for nuclei (or ∼2.5 times less if a Bohm diffusion regime is assumed), roughly independently of the compression ratio assumed at the shock. Even by taking advantage of the uncertainties on the measured parameters, it appears very difficult for the considered SNRs in their current stage of evolution to produce protons up to the knee of the cosmic-ray spectrum, at ∼3 × 10 15 eV, and essentially impossible to accelerate Fe nuclei up to either the ankle at ∼3 × 10 18 eV or the second knee at ∼5 × 10 17 eV.

247 citations


Journal ArticleDOI
TL;DR: A proton-selective method to determine 17O-1H distances in organic, biological, and biomimetic materials by fast magic-angle-spinning solid-state NMR spectroscopy using the newly developed symmetry-based radiofrequency pulse sequence.
Abstract: We present a proton-selective method to determine 17O-1H distances in organic, biological, and biomimetic materials by fast magic-angle-spinning solid-state NMR spectroscopy. This method allows the determination of internuclear distances between specific (17O, 1H) spin pairs selectively. It enables the estimation of medium-range 17O...1H distances across hydrogen bonds in the presence of short-range 17O-1H contacts sharing the same 17O site. The method employs the newly developed symmetry-based radiofrequency pulse sequence SR%@mt;sys@%4%@sx@%1%@be@%2%@sxx@%%@mx@% applied to the protons to achieve heteronuclear dipolar recoupling, while simultaneously decoupling the homonuclear proton dipolar interactions. Fast MAS (50 kHz) and high static magnetic fields (18.8 T) achieve the required proton spectral resolution.

244 citations


Journal ArticleDOI
A. Aktas, H. Henschel, Wolfram Erdmann1, G. Nowak2  +304 moreInstitutions (31)
TL;DR: In this article, cross sections for elastic production of J/Psi mesons in photoproduction and electroproduction are measured in electron proton collisions at HERA using an integrated luminosity of 55 pb^{-1}.
Abstract: Cross sections for elastic production of J/Psi mesons in photoproduction and electroproduction are measured in electron proton collisions at HERA using an integrated luminosity of 55 pb^{-1}. Results are presented for photon virtualities Q^2 up to 80 GeV^2. The dependence on the photon-proton centre of mass energy W_{gamma p} is analysed in the range 40 < \Wgp < 305 GeV in photoproduction and 40 < \Wgp < 160 GeV in electroproduction. The \Wgp dependences of the cross sections do not change significantly with Q^2 and can be described by models based on perturbative QCD. Within such models, the data show a high sensitivity to the gluon density of the proton in the domain of low Bjorken x and low Q^2. Differential cross sections d\sigma/dt, where t is the squared four-momentum transfer at the proton vertex, are measured in the range |t|<1.2 GeV^2 as functions of \Wgp and Q^2. Effective Pomeron trajectories are determined for photoproduction and electroproduction. The J/Psi production and decay angular distributions are consistent with s-channel helicity conservation. The ratio of the cross sections for longitudinally and transversely polarised photons is measured as a function of Q^2 and is found to be described by perturbative QCD based models.

238 citations


Journal ArticleDOI
TL;DR: In this article, the authors explore the production of these nuclei in the neutrino-driven wind from a young neutron star, and find synthesis of p-rich nuclei up to 102Pd, although their calculations do not show efficient production of 92Mo.
Abstract: One of the outstanding unsolved riddles of nuclear astrophysics is the origin of the so-called p-process nuclei from A = 92 to 126. Both the lighter and heavier p-process nuclei are adequately produced in the neon and oxygen shells of ordinary Type II supernovae, but the origin of these intermediate isotopes, especially 92,94Mo and 96,98Ru, has long been mysterious. Here we explore the production of these nuclei in the neutrino-driven wind from a young neutron star. We consider such early times that the wind still contains a proton excess because the rates for νe and positron captures on neutrons are faster than those for the inverse captures on protons. Following a suggestion by Frohlich and coworkers, we also include the possibility that—in addition to the protons, α-particles, and heavy seed—a small flux of neutrons is maintained by the reaction p(e, e+)n. This flux of neutrons is critical in bridging the long waiting points along the path of the rp-process by (n, p) reactions. Using the unmodified ejecta histories from a recent two-dimensional supernova model by Janka and coworkers, we find synthesis of p-rich nuclei up to 102Pd, although our calculations do not show efficient production of 92Mo. If the entropy of these ejecta is increased by a factor of 2, the synthesis extends to 120Te. Still larger increases in entropy, which might reflect the role of magnetic fields or vibrational energy input neglected in the hydrodynamical model, result in the production of nuclei up to A ≈ 170. Elements synthesized in these more extreme outflows include numerous s- and p-process nuclei, and even some r-process nuclei can be synthesized in these proton-rich conditions.

230 citations


Journal ArticleDOI
Joseph Adams1, Madan M. Aggarwal2, Zubayer Ahammed3, J. Amonett4  +380 moreInstitutions (45)
TL;DR: In this article, the transverse momentum spectra for identified charged pions, protons and anti-protons from p + p and d + Au collisions at s NN = 200 GeV were measured around midrapidity ( | y | 0.5 ) over the range of 0.3 p T 10 GeV / c with particle identification from the ionization energy loss and its relativistic rise in the time projection chamber and time-of-flight in STAR.

Journal ArticleDOI
TL;DR: The steps in the mechanism of proton transport in bacteriorhodopsin include examples for most kinds ofProton transfer reactions that might occur in a transmembrane pump: proton transfer via a bridging water molecule, coupled protonation/deprotonation of two buried groups separated by a considerable distance, long-range proton migration over a hydrogen-bonded aqueous chain.

Journal ArticleDOI
TL;DR: The result is the first estimate of the isospin structure of NN-SRCs in nuclei, and may have important implication for modeling the equation of state of asymmetric nuclear matter.
Abstract: We analyze recent data from high-momentum-transfer ($p$, $pp$) and ($p$, $ppn$) reactions on carbon. For this analysis, the two-nucleon short-range correlation ($NN$-SRC) model for backward nucleon emission is extended to include the motion of the $NN$ pair in the mean field. The model is found to describe major characteristics of the data. Our analysis demonstrates that the removal of a proton from the nucleus with initial momentum $275\char21{}550\text{ }\text{ }\mathrm{MeV}/c$ is ${92}_{\ensuremath{-}18}^{+8}%$ of the time accompanied by the emission of a correlated neutron that carries momentum roughly equal and opposite to the initial proton momentum. This indicates that the probabilities of $pp$ or $nn$ SRCs in the nucleus are at least a factor of 6 smaller than that of $pn$ SRCs. Our result is the first estimate of the isospin structure of $NN$-SRCs in nuclei, and may have important implication for modeling the equation of state of asymmetric nuclear matter.

Journal ArticleDOI
TL;DR: In this paper, the authors used the simulation kit GEANT4 to calculate proton cooling efficiency including pion-multiplicity and proton-inelasticity in photomeson production.
Abstract: High energy neutrino emission from gamma-ray bursts (GRBs) is discussed. In this paper, by using the simulation kit GEANT4, we calculate proton cooling efficiency including pion-multiplicity and proton-inelasticity in photomeson production. First, we estimate the maximum energy of accelerated protons in GRBs. Using the obtained results, neutrino flux from one burst and a diffuse neutrino background are evaluated quantitatively. We also take account of cooling processes of pion and muon, which are crucial for resulting neutrino spectra. We confirm the validity of analytic approximate treatments on GRB fiducial parameter sets, but also find that the effects of multiplicity and high-inelasticity can be important on both proton cooling and resulting spectra in some cases. Finally, assuming that the GRB rate traces the star formation rate, we obtain a diffuse neutrino background spectrum from GRBs for specific parameter sets. We introduce the nonthermal baryon-loading factor, rather than assume that GRBs are main sources of ultra-high energy cosmic rays (UHECRs). We find that the obtained neutrino background can be comparable with the prediction of Waxman and Bahcall, although our ground in estimation is different from theirs. In this paper, we study on various parameters since there are many parameters in the model. Themore » detection of high energy neutrinos from GRBs will be one of the strong evidences that protons are accelerated to very high energy in GRBs. Furthermore, the observations of a neutrino background has a possibility not only to test the internal shock model of GRBs but also to give us information about parameters in the model and whether GRBs are sources of UHECRs or not.« less

Journal ArticleDOI
TL;DR: In this article, the relativistic electron dropout event on 20 November 2003 was studied using data from a number of satellites including SAMPEX, HEO, ACE, POES, and FAST.
Abstract: [1] The relativistic electron dropout event on 20 November 2003 is studied using data from a number of satellites including SAMPEX, HEO, ACE, POES, and FAST. The observations suggest that the dropout may have been caused by two separate mechanisms that operate at high and low L-shells, respectively, with a separation at L ∼ 5. At high L-shells (L > 5), the dropout is approximately independent of energy and consistent with losses to the magnetopause aided by the Dst effect and outward radial diffusion which can deplete relativistic electrons down to lower L-shells. At low L-shells (L < 5), the dropout is strongly energy-dependent, with the higher-energy electrons being affected most. Moreover, large precipitation bands of both relativistic electrons and energetic protons are observed at low L-shells which are consistent with intense pitch angle scattering driven by electromagnetic ion cyclotron (EMIC) waves and may result in a rapid loss of relativistic electrons near the plasmapause in the dusk sector or in plumes of enhanced density.

Journal ArticleDOI
TL;DR: The dynamical behavior of excess protons in liquid water is investigated using femtosecond vibrational pump-probe spectroscopy and the interconversion between the H9O4 (Eigen) and H5O2(+) (Zundel) hydration structures of the proton is observed.
Abstract: The dynamical behavior of excess protons in liquid water is investigated using femtosecond vibrational pump-probe spectroscopy. By resonantly exciting the O-H+-stretching mode of the H9O4(+) (Eigen) hydration structure of the proton and probing the subsequent absorption change over a broad frequency range, the dynamics of the proton is observed in real time. The lifetime of the protonic stretching mode is found to be approximately 120 fs, shorter than for any other vibration in liquid water. We also observe the interconversion between the H9O4(+) (Eigen) and H5O2(+) (Zundel) hydration structures of the proton. This interconversion, which constitutes an essential step of proton transport in water, is found to occur on an extremely fast (< 100 fs) time scale.

Journal ArticleDOI
TL;DR: The review focuses on the anisotropy of proton transfer at the surface of biological membranes, and considers the data from "pulsed" experiments, where light-triggered enzymes capture or eject protons at the membrane surface, the electrostatic properties of water at charged interfaces, and the specific structural attributes of pro-translocating enzymes.

Journal ArticleDOI
TL;DR: In this article, a hybrid particle-in-cell (HPC) code is used to simulate the laser-plasmas interaction and its effect on the electron production and transport, as well as the distributed acceleration and spatial distribution.
Abstract: High current, energetic protons are produced by irradiating thin metal foils with intense lasers. Here, the laser plasma interaction produces relativistic electrons at the critical surface. These electrons propagate through the foil and create a space-charge cloud that accelerates proton contaminants on the back side. Self-consistent electromagnetic simulations of this process using a hybrid particle-in-cell code show the importance of detailed modeling of the electron production and transport, as well as the distributed acceleration and spatial distribution of the protons well off the foil surface. The protons become neutralized by energetic electrons resupplied by the expanding plume of the back surface, not by energetic electrons thermalizing within the proton cloud. Details of the laser-plasma interaction simulation techniques and implications for ion-driven fast ignition are also discussed.

Journal ArticleDOI
TL;DR: The solvation and transport properties of the sulfonate-hydronium ion pair have been studied in hydrated Nafion through molecular dynamics simulation and the association of the hydrated proton with the hydrophobic polymer backbone suggests its amphiphile-like behavior.
Abstract: The solvation and transport properties of the sulfonate−hydronium ion pair have been studied in hydrated Nafion through molecular dynamics simulation. Explicit proton and charge delocalization of the excess proton transport, via the Grotthuss hopping mechanism, were treated using the self-consistent multistate empirical valence bond (SCI-MS-EVB) method. The nature of the sulfonate−hydronium ion pair was characterized through analysis of free-energy profiles. It was found that, in general, the excess proton is solvated between two water molecules of a Zundel moiety while in the contact ion pair position, but then it transitions to an Eigen-like configuration in the solvent-separated pair position. Furthermore, the positive charge associated with the excess proton passes between the contact and solvent-separated ion pair positions through the Grotthuss mechanism rather than simple vehicular diffusion. The total proton diffusion was decomposed into vehicular and Grotthuss components and were found to be of t...

Journal ArticleDOI
TL;DR: Comparisons are made to Boltzmann-Uehling-Uhlenbeck transport calculations and conclusions concerning the density dependence of the asymmetry term of the nuclear equation of state at subnuclear densities are made.
Abstract: Recent measurements of preequilibrium neutron and proton transverse emission from $^{112,124}\mathrm{Sn}+^{112,124}\mathrm{Sn}$ reactions at $50\text{ }\text{ }\mathrm{MeV}/A$ have been completed at the National Superconducting Cyclotron Laboratory. Free nucleon transverse emission ratios are compared to those of $A=3$ mirror nuclei. Comparisons are made to Boltzmann-Uehling-Uhlenbeck (BUU) transport calculations and conclusions concerning the density dependence of the asymmetry term of the nuclear equation of state at subnuclear densities are made. Comparison to BUU model predictions indicate a density dependence of the asymmetry energy that is closer to a form in which the asymmetry energy increases as the square root of the density for the density region studied. A coalescent-invariant analysis is introduced as a means of reducing suggested difficulties with cluster emission in total nucleon emission.

Journal ArticleDOI
TL;DR: In this paper, the conductivity of acceptor-doped LaNbO 4 has been investigated in the temperature range 300 to 1200 °C as a function of the oxygen pressure and water vapor pressure by means of impedance spectroscopy and EMF measurements.

Journal ArticleDOI
TL;DR: In this paper, the astrophysical p process, which is responsible for the origin of the proton rich stable nuclei heavier than iron, was investigated using a full nuclear reaction network for a type II supernova explosion when the shock front passes through the O/Ne layer.
Abstract: The astrophysical p process, which is responsible for the origin of the proton rich stable nuclei heavier than iron, was investigated using a full nuclear reaction network for a type II supernova explosion when the shock front passes through the O/Ne layer. Calculations were performed with a multi-layer model adopting the seed of a pre-explosion evolution of a 25 solar mass star. The reaction flux was calculated to determine the main reaction path and branching points responsible for synthesizing the proton rich nuclei. In order to investigate the impact of nuclear reaction rates on the predicted p-process abundances, extensive simulations with different sets of collectively and individually modified neutron-, proton-, alpha-capture and photodisintegration rates have been performed. These results are not only relevant to explore the nuclear physics related uncertainties in p-process calculations but are also important for identifying the strategy and planning of future experiments.

Journal ArticleDOI
TL;DR: In this article, the authors compared the cosmogenic neutrino flux from mixed composition sources to that from pure proton sources and found that the mixed composition case has a high energy peak, mainly due to photopion production off CMB photons, of similar shape and amplitude to those in the proton case.
Abstract: We calculate the flux of neutrinos generated by the propagation of ultrahigh energy nuclei over cosmological distances. The propagation takes into account the interactions with cosmic background radiations including the CMB and the most recent estimates of higher energy (infrared, optical, and ultraviolet) backgrounds. We assume that the composition of ultrahigh energy cosmic rays (UHECRs) at the source is the same as the one observed at low energies. This assumption fits the present data well at the highest energies. We compare the cosmogenic neutrino flux from mixed composition sources to that from pure proton sources. We find that the neutrino flux in the mixed composition case has a high energy peak, mainly due to photopion production off CMB photons, of similar shape and amplitude to those in the proton case. At low energies both composition cases have significant neutrino flux with a peak around 1014.5 eV due to the higher energy backgrounds. The mixed composition case induces a higher flux of neutrinos at energies below 1013 eV due to the neutron decay component that extends down to low energies. Detection of diffuse neutrino fluxes at ultrahigh energies can strongly constrain the source distribution of UHECRs whereas fluxes at lower energies could be used to constrain confinement of VHE and UHE cosmic rays if combined with composition analysis from cosmic ray experiments.

Journal ArticleDOI
TL;DR: The experiments of proton irradiation to a rabbit and the imaging of the activity were performed, and the difference between the two images acquired from the measurement of the BOLPs was confirmed to clearly identify the proton-irradiated volume.
Abstract: Proton therapy is one form of radiotherapy in which the irradiation can be concentrated on a tumor using a scanned or modulated Bragg peak. Therefore, it is very important to evaluate the proton-irradiated volume accurately. The proton-irradiated volume can be confirmed by detection of pair annihilation gamma rays from positron emitter nuclei generated by the target nuclear fragment reaction of irradiated proton nuclei and nuclei in the irradiation target using a positron emission tomography (PET) apparatus, and dose-volume delivery guided proton therapy (DGPT) can thereby be achieved using PET images. In the proton treatment room, a beam ON-LINE PET system (BOLPs) was constructed so that a PET apparatus of the planar-type with a high spatial resolution of about 2 mm was mounted with the field of view covering the isocenter of the beam irradiation system. The position and intensity of activity were measured using the BOLPs immediately after the proton irradiation of a gelatinous water target containing 16O nuclei at different proton irradiation energy levels. The change of the activity-distribution range against the change of the physical range was observed within 2 mm. The experiments of proton irradiation to a rabbit and the imaging of the activity were performed. In addition, the proton beam energy used to irradiate the rabbit was changed. When the beam condition was changed, the difference between the two images acquired from the measurement of the BOLPs was confirmed to clearly identify the proton-irradiated volume.

Journal ArticleDOI
TL;DR: In this paper, Fourier transform infrared spectroscopy (FTIR), temperature-programmed desorption (TPD), X-ray diffraction (XRD), and electrochemical techniques were used to characterize SnP 2 O 7 -based proton conductors.
Abstract: SnP 2 O 7 -based proton conductors were characterized by Fourier transform infrared spectroscopy (FTIR), temperature-programmed desorption (TPD), X-ray diffraction (XRD), and electrochemical techniques. Undoped SnP 2 O 7 showed overall conductivities greater than 10 -2 S cm -1 in the temperature range of 75-300°C. The proton transport numbers of this material at 250°C under various conditions were estimated, based on the ratio of the electromotive force of the galvanic cells to the theoretical values, to be 0.97-0.99 in humidified H 2 and 0.89-0.92 under fuel cell conditions. Partial substitution of In 3+ for Sn 4+ led to an increase in the proton conductivity (from 5.56 X 10 -2 to 1.95 X 10 -1 S cm -1 at 250°C, for example). FTIR and TPD measurements revealed that the effects of doping on the proton conductivity could be attributed to an increase in the proton concentration in the bulk Sn 1-x In x P 2 O 7 . The deficiency of P 2 O 2 ions in the Sn 1-x In x P 2 O 7 bulk decreased the proton conductivity by several orders of magnitude, which was explained as due to a decrease in the proton mobility rather than the proton concentration. The mechanism of proton incorporation and conduction is examined and discussed in detail.

Journal ArticleDOI
TL;DR: An energetics motivated framework is established that hinges on the donor/acceptor pKa values and electrostatics due to the environment to argue that the "proton hole" transfer is likely as important as the classical Grotthuss mechanism for proton transport in many complex molecular systems.
Abstract: Proton transfers are fundamental to chemical processes in solution and biological systems. Often, the well-known Grotthuss mechanism is assumed where a series of sequential "proton hops" initiates from the donor and combines to produce the net transfer of a positive charge over a long distance. Although direct experimental evidence for the sequential proton hopping has been obtained recently, alternative mechanisms may be possible in complex molecular systems. To understand these events, all accessible protonation states of the mediating groups should be considered. This is exemplified by transfers through water where the individual water molecules can exist in three protonation states (water, hydronium, and hydroxide); as a result, an alternative to the Grotthuss mechanism for a proton transfer through water is to generate a hydroxide by first protonating the acceptor and then transfer the hydroxide toward the donor through water. The latter mechanism can be most generally described as the transfer of a "proton hole" from the acceptor to the donor where the "hole" characterizes the deprotonated state of any mediating molecule. This pathway is distinct and is rarely considered in the discussion of proton-transfer processes. Using a calibrated quantum mechanical/molecular mechanical (QM/MM) model and an effective sampling technique, we study proton transfers in two solution systems and in Carbonic Anhydrase II. Although the relative weight of the "proton hole" and Grotthuss mechanisms in a specific system is difficult to determine precisely using any computational approach, the current study establishes an energetics motivated framework that hinges on the donor/acceptor pKa values and electrostatics due to the environment to argue that the "proton hole" transfer is likely as important as the classical Grotthuss mechanism for proton transport in many complex molecular systems.

Journal ArticleDOI
TL;DR: Simulation and comparison of the rate constant and H/D kinetic isotope effect with theoretical predictions show that the experimental value of the preexponential factor is ca.
Abstract: Proton-coupled electron transfers currently attract considerable attention in view of their likely involvement in many natural processes. Electrochemistry, through techniques such as cyclic voltammetry, is an efficient way of investigating the reaction mechanism of these reactions, and deciding whether proton and electron transfers are concerted or occur in a stepwise manner. The oxidation of an ortho-substituted 4,6-di (tert-butyl)-phenol in which the phenolic hydrogen atom is transferred during the reaction to the nitrogen atom of a nearby amine is taken as illustrative example. A careful analysis of the cyclic voltammetric responses obtained with this compound and its OD derivative allows, after estimation of the various thermodynamic parameters, ruling out the occurrence of the square scheme mechanism involving the proton−electron and electron−proton sequences. Simulation and comparison of the rate constant and H/D kinetic isotope effect with theoretical predictions show that the experimental value of...

Journal ArticleDOI
TL;DR: In this article, the authors investigated the effect of fire hose instability on the proton temperature anisotropy in the expanding solar wind, and concluded that both parallel and oblique fire hose instabilities constrain the anisotropic behavior.
Abstract: [1] Oblique fire hose instability is investigated using hybrid simulations for proton betas of the order of one and for proton parallel temperatures sufficiently greater than the perpendicular ones. The simulations confirm previous simulation results showing that this instability has self-destructing properties and efficiently reduces the proton temperature anisotropy. A parametric study using one-dimensional standard hybrid simulations shows that stronger changes in the temperature anisotropy and stronger wave emissions appear for larger initial temperature anisotropies. An ideal, slow plasma expansion, modeled by a two-dimensional hybrid expanding box simulation, leads to a generation of proton temperature anisotropy. The anisotropy leads first to destabilization of the dominant parallel fire hose, which interacts mainly with minor supra-Alfvenic protons, whereas the evolution of core protons is determined by expansion. Consequently, the effective anisotropy is only slightly reduced and the system eventually becomes unstable with respect to the oblique fire hose instability. The oblique fire hose strongly scatters the protons and removes the anisotropy disrupting the parallel fire hose. An important portion of the fluctuating wave energy is dissipated to protons, and only long wavelength waves remain in the system. The system with low wave activity then develops again larger temperature anisotropies, and the evolution repeats itself. It is concluded that both parallel and oblique proton fire hose instabilities constrain the proton temperature anisotropy in the expanding solar wind, with the latter one constituting a final frontier for the anisotropy. These results give a possible explanation of some apparent discrepancies between observations and linear predictions. In addition, a simple bounded anisotropy model is developed to include some of the kinetic effects of the fire hose instabilities in fluid models.

Journal ArticleDOI
TL;DR: In this article, the results of 1D particle-in-cell simulations of ultrarelativistic shock waves in proton-electron-positron plasmas were reported.
Abstract: We report the results of 1D particle-in-cell simulations of ultrarelativistic shock waves in proton-electron-positron plasmas. We consider magnetized shock waves, in which the upstream medium carries a large scale magnetic field, directed transverse to the flow. Relativistic cyclotron instability of each species as the incoming particles encounter the increasing magnetic field within the shock front provides the basic plasma heating mechanism. The most significant new results come from simulations with mass ratio $m_p/m_\pm = 100$. We show that if the protons provide a sufficiently large fraction of the upstream flow energy density (including particle kinetic energy and Poynting flux), a substantial fraction of the shock heating goes into the formation of suprathermal power-law spectra of pairs. Cyclotron absorption by the pairs of the high harmonic ion cyclotron waves, emitted by the protons, provides the non-thermal acceleration mechanism. As the proton fraction increases, the non-thermal efficiency increases and the pairs' power-law spectra harden. We suggest that the varying power law spectra observed in synchrotron sources powered by magnetized winds and jets might reflect the correlation of the proton to pair content enforced by the underlying electrodynamics of these sources' outflows, and that the observed correlation between the X-ray spectra of rotation powered pulsars with the X-ray spectra of their nebulae might reflect the same correlation.

Journal ArticleDOI
TL;DR: In this paper, the authors used the systematics of folding potentials to analyze the half-life of superheavy nuclei and predicted double shell closure for the first time for all nuclei under study.
Abstract: Systematic \ensuremath{\alpha}-nucleus folding potentials are used to analyze \ensuremath{\alpha}-decay half-lives of superheavy nuclei. Preformation factors of about several percent are found for all nuclei under study. The systematic behavior of the preformation factors and the volume integrals of the potentials allows predictions of \ensuremath{\alpha}-decay energies and half-lives for unknown nuclei. Shell closures can be determined from measured \ensuremath{\alpha}-decay energies using the discontinuity of the volume integral at shell closures. For the first time a double shell closure is predicted for ${Z}_{\mathrm{magic}}=132,{N}_{\mathrm{magic}}=194$, and ${A}_{\mathrm{magic}}=326$ from the systematics of folding potentials. The calculated \ensuremath{\alpha}-decay half-lives remain far below 1 ns for superheavy nuclei with double shell closure and masses $Ag300$ independent of the precise knowledge of the magic proton and neutron numbers.