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Bernard H Ramsahoye
Researcher at University of Edinburgh
Publications - 13
Citations - 2828
Bernard H Ramsahoye is an academic researcher from University of Edinburgh. The author has contributed to research in topics: DNA methylation & CpG site. The author has an hindex of 10, co-authored 13 publications receiving 2589 citations. Previous affiliations of Bernard H Ramsahoye include Edinburgh Cancer Research Centre & University of Cambridge.
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Journal ArticleDOI
Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans.
Brian J. Haas,Sophien Kamoun,Sophien Kamoun,Michael C. Zody,Michael C. Zody,Rays H. Y. Jiang,Rays H. Y. Jiang,Robert E. Handsaker,Liliana M. Cano,Manfred Grabherr,Chinnappa D. Kodira,Chinnappa D. Kodira,Sylvain Raffaele,Trudy Torto-Alalibo,Trudy Torto-Alalibo,Tolga O. Bozkurt,Audrey M. V. Ah-Fong,Lucia Alvarado,Vicky L. Anderson,Miles R. Armstrong,Anna O. Avrova,Laura Baxter,Jim Beynon,Petra C. Boevink,Stephanie R. Bollmann,Jorunn I. B. Bos,Vincent Bulone,Guohong Cai,Cahid Cakir,James C. Carrington,Megan Chawner,Lucio Conti,Stefano Costanzo,Richard Ewan,Noah Fahlgren,Michael A. Fischbach,Johanna Fugelstad,Eleanor M. Gilroy,Sante Gnerre,Pamela J. Green,Laura J. Grenville-Briggs,John Griffith,Niklaus J. Grünwald,Karolyn Horn,Neil R. Horner,Chia-Hui Hu,Edgar Huitema,Dong-Hoon Jeong,Alexandra M. E. Jones,Jonathan D. G. Jones,Richard W. Jones,Elinor K. Karlsson,Sridhara G. Kunjeti,Kurt Lamour,Zhenyu Liu,Li-Jun Ma,Dan MacLean,Marcus C. Chibucos,Hayes McDonald,Jessica McWalters,Harold J. G. Meijer,William Morgan,Paul Morris,Carol A. Munro,Keith O'Neill,Keith O'Neill,Manuel D. Ospina-Giraldo,Andrés Pinzón,Leighton Pritchard,Bernard H Ramsahoye,Qinghu Ren,Silvia Restrepo,Sourav Roy,Ari Sadanandom,Alon Savidor,Sebastian Schornack,David C. Schwartz,Ulrike Schumann,Ben Schwessinger,Lauren Seyer,Ted Sharpe,Cristina Silvar,Jing Song,David J. Studholme,Sean M. Sykes,Marco Thines,Marco Thines,Peter J. I. van de Vondervoort,Vipaporn Phuntumart,Stephan Wawra,R. Weide,Joe Win,Carolyn A. Young,Shiguo Zhou,William E. Fry,Blake C. Meyers,Pieter van West,Jean B. Ristaino,Francine Govers,Paul R. J. Birch,Stephen C. Whisson,Howard S. Judelson,Chad Nusbaum +102 more
TL;DR: The sequence of the P. infestans genome is reported, which at ∼240 megabases (Mb) is by far the largest and most complex genome sequenced so far in the chromalveolates and probably plays a crucial part in the rapid adaptability of the pathogen to host plants and underpins its evolutionary potential.
Journal ArticleDOI
Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development
TL;DR: Genetic and biochemical data together favor the view that MBD3 is a key component of the Mi-2/NuRD corepressor complex, whereas MBD2 may be one of several factors that can recruit this complex to DNA.
Journal ArticleDOI
Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
Elaine R. Nimmo,James G. D. Prendergast,Marian C Aldhous,Nicholas A. Kennedy,Paul Henderson,Paul Henderson,Hazel E. Drummond,Bernard H Ramsahoye,David C. Wilson,Colin A. Semple,Jack Satsangi +10 more
TL;DR: A global methylation profile characteristic of ileal CD is defined and methylation status was predictive of disease status (sensitivity 0.71, specificity 0.83), providing an important insight into the impact of epigenetic mechanisms in the pathogenesis of CD.
Journal ArticleDOI
Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns
Duncan Sproul,Robert R. Kitchen,Robert R. Kitchen,Colm E. Nestor,J Michael Dixon,Andrew H. Sims,David J. Harrison,David J. Harrison,Bernard H Ramsahoye,Richard R. Meehan +9 more
TL;DR: The methylation profiles of 1,154 cancers from 7 different tissue types are analyzed and it is suggested that aberrantly hypermethylated genes are already repressed in pre-cancerous tissue and their hypermethylation does not directly contribute to cancer development via silencing.
Journal ArticleDOI
Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer
Duncan Sproul,Colm E. Nestor,Jayne Culley,Jacqueline Dickson,J Michael Dixon,J Michael Dixon,David J. Harrison,Richard R. Meehan,Andrew H. Sims,Bernard H Ramsahoye +9 more
TL;DR: The findings implicate aberrant DNA methylation as a marker of cell lineage rather than tumor progression and suggest that, in most cases, it does not cause the repression with which it is associated.