C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Parental Occurrence of Premature Cardiovascular Disease Predicts Increased Coronary Artery and Abdominal Aortic Calcification in the Framingham Offspring and Third Generation Cohorts
Nisha I. Parikh,Shih-Jen Hwang,Martin G. Larson,L. Adrienne Cupples,Caroline S. Fox,Emily S. Manders,Joanne M. Murabito,Joseph M. Massaro,Udo Hoffmann,Christopher J. O'Donnell +9 more
TL;DR: Risk conferred by parental premature CVD on vascular calcification may be mediated through novel mechanisms not accounted for by classic CVD risk factors known to cause atherosclerosis, particularly in younger middle-aged adults.
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Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study).
Gregory D. Lewis,Philimon Gona,Martin G. Larson,Jonathan F. Plehn,Emelia J. Benjamin,Christopher J. O'Donnell,Christopher J. O'Donnell,Daniel Levy,Ramachandran S. Vasan,Thomas J. Wang +9 more
TL;DR: In middle-aged adults, diastolic BP during low-intensity exercise and recovery predicted incident CVD in multivariable models, supporting the concept that dynamic BP provides incremental information to BP at rest and suggesting that exercise diastsolic BP may be a better predictor than exercise systolic BP in this age group.
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Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes
Erik Ingelsson,Lisa M. Sullivan,Joanne M. Murabito,Caroline S. Fox,Emelia J. Benjamin,Joseph F. Polak,James B. Meigs,Michelle J. Keyes,Christopher J. O'Donnell,Christopher J. O'Donnell,Thomas J. Wang,Ralph B. D'Agostino,Philip A. Wolf,Ramachandran S. Vasan,Ramachandran S. Vasan +14 more
TL;DR: In this community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition.
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Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study.
Thomas J. Wang,Byung-Ho Nam,Ralph B. D'Agostino,Ralph B. D'Agostino,Philip A. Wolf,Philip A. Wolf,Donald M. Lloyd-Jones,Calum A. MacRae,Peter W.F. Wilson,Peter W.F. Wilson,Joseph F. Polak,Christopher J. O'Donnell,Christopher J. O'Donnell +12 more
TL;DR: Early-onset parental CHD, in particular, identifies offspring with a strong familial predisposition to atherosclerosis, which is more prevalent in individuals with a family history of CHD.
Journal ArticleDOI
Use of Tissue Velocity Imaging in the Diagnosis of Fetal Cardiac Arrhythmias
Azaria J.J.T. Rein,Christopher J. O'Donnell,Tal Geva,Amiram Nir,Zeev Perles,Ikuo Hashimoto,Xiaokui Li,David J. Sahn +7 more
TL;DR: The fetal kinetocardiogram opens a new window to aid in the diagnosis and understanding of fetal arrhythmias, and it provides a tool for studying the action of antiarrhythmic drugs and their effects on electrophysiological conduction in the fetal heart.