C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Regional comparisons of banking performance in South Africa
Journal ArticleDOI
Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs
Xiaoling Zhang,Hinco J. Gierman,Daniel Levy,Andrew S. Plump,Radu Dobrin,Harald H H Göring,Joanne E. Curran,Matthew P. Johnson,John Blangero,Stuart K. Kim,Christopher J. O'Donnell,Valur Emilsson,Andrew D. Johnson +12 more
TL;DR: Analysis of 45 full human GWAS scans indicates eQTLs are enriched overall, and above nSNPs, among positive statistical signals in genetic mapping studies, and account for a significant fraction of the strongest human trait effects.
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Dissecting the Roles of MicroRNAs in Coronary Heart Disease via Integrative Genomic Analyses
Tianxiao Huan,Jian Rong,Kahraman Tanriverdi,Qingying Meng,Anindya Bhattacharya,David D. McManus,Roby Joehanes,Themistocles L. Assimes,Ruth McPherson,Nilesh J. Samani,Jeanette Erdmann,Heribert Schunkert,Paul Courchesne,Peter J. Munson,Andrew D. Johnson,Christopher J. O'Donnell,Bin Zhang,Martin G. Larson,Jane E. Freedman,Daniel Levy,Xia Yang +20 more
TL;DR: Novel evidence is provided that miRNAs are important regulators of biological processes involved in CHD via genetic control and via their tight coexpression with mRNAs.
Journal ArticleDOI
Matrix Gla protein polymorphisms are associated with coronary artery calcification in men.
Michael D. Crosier,Sarah L. Booth,Inga Peter,Bess Dawson-Hughes,Paul A. Price,Christopher J. O'Donnell,Udo Hoffmann,Matthew K. Williamson,Jose M. Ordovas +8 more
TL;DR: A role for MGP genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations is suggested, despite the fact that genetic variation in MGP was associated with serum M GP concentrations.
Journal ArticleDOI
Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.
Frank J. A. van Rooij,Rehan Qayyum,Albert V. Smith,Yi Zhou,Stella Trompet,Toshiko Tanaka,Margaux F. Keller,Li Ching Chang,Helena Schmidt,Min-Lee Yang,Ming-Huei Chen,Ming-Huei Chen,James E. Hayes,Andrew D. Johnson,Lisa R. Yanek,Christian Mueller,Leslie A. Lange,James S. Floyd,Mohsen Ghanbari,Mohsen Ghanbari,Alan B. Zonderman,J. Wouter Jukema,Albert Hofman,Albert Hofman,Cornelia M. van Duijn,Karl C. Desch,Yasaman Saba,Ayse Bilge Ozel,Beverly M. Snively,Jer-Yuarn Wu,Jer-Yuarn Wu,Reinhold Schmidt,Myriam Fornage,Robert J. Klein,Caroline S. Fox,Koichi Matsuda,Naoyuki Kamatani,Philipp S. Wild,David J. Stott,Ian Ford,P. Eline Slagboom,Jaden Yang,Audrey Y. Chu,Amy J. Lambert,André G. Uitterlinden,Oscar H. Franco,Edith Hofer,David Ginsburg,Bella Hu,Brendan J. Keating,Ursula M. Schick,Ursula M. Schick,Jennifer A. Brody,Jun Li,Zhao Chen,Tanja Zeller,Jack M. Guralnik,Daniel I. Chasman,Luanne L. Peters,Michiaki Kubo,Diane M. Becker,Jin Li,Gudny Eiriksdottir,Jerome I. Rotter,Daniel Levy,Vera Grossmann,Kushang V. Patel,Chien-Hsiun Chen,Chien-Hsiun Chen,Paul M. Ridker,Hua Tang,Lenore J. Launer,Kenneth Rice,Ruifang Li-Gao,Luigi Ferrucci,Michelle K. Evans,Avik Choudhuri,Eirini Trompouki,Eirini Trompouki,Brian J. Abraham,Song Yang,Atsushi Takahashi,Yoichiro Kamatani,Charles Kooperberg,Tamara B. Harris,Sun Ha Jee,Josef Coresh,Fuu Jen Tsai,Dan L. Longo,Yuan-Tsong Chen,Janine F. Felix,Qiong Yang,Qiong Yang,Bruce M. Psaty,Bruce M. Psaty,Eric Boerwinkle,Lewis C. Becker,Dennis O. Mook-Kanamori,Dennis O. Mook-Kanamori,James G. Wilson,Vilmundur Gudnason,Christopher J. O'Donnell,Abbas Dehghan,Abbas Dehghan,L. Adrienne Cupples,L. Adrienne Cupples,Mike A. Nalls,Andrew P. Morris,Andrew P. Morris,Yukinori Okada,Alexander P. Reiner,Alexander P. Reiner,Leonard I. Zon,Santhi K. Ganesh +113 more
TL;DR: The utility of trans-ethnic GWASs for discovery and characterization of genetic loci influencing hematologic traits are shown, demonstrating that RBPMS is a regulator of erythropoiesis and supporting the statistical fine-mapping at this locus.