C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study.
George Thanassoulis,Joseph M. Massaro,Udo Hoffmann,Amir A. Mahabadi,Ramachandran S. Vasan,Christopher J. O'Donnell,Caroline S. Fox +6 more
TL;DR: Although prevalence of pericardial fat and intrathoracic fat were comparable at 30%, intrath oracicFat correlated more closely with metabolic risk and visceralFat on thoracic imaging.
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Comprehensive Survey of Common Genetic Variation at the Plasminogen Activator Inhibitor-1 Locus and Relations to Circulating Plasminogen Activator Inhibitor-1 Levels
Sekar Kathiresan,Stacey Gabriel,Qiong Yang,Amy L. Lochner,Martin G. Larson,Daniel Levy,Geoffrey H. Tofler,Joel N. Hirschhorn,Christopher J. O'Donnell +8 more
TL;DR: For quantitative cardiovascular traits such as circulating biomarkers, defining LD structure in a candidate gene followed by association analyses with both SNPs and haplotypes is an effective approach to localize common susceptibility alleles.
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Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset
Adam S. Gordon,Holly K. Tabor,Andrew D. Johnson,Beverly M. Snively,Themistocles L. Assimes,Paul L. Auer,John P. A. Ioannidis,Ulrike Peters,Jennifer G. Robinson,Lara Sucheston,Danxin Wang,Nona Sotoodehnia,Jerome I. Rotter,Bruce M. Psaty,Rebecca D. Jackson,David M. Herrington,Christopher J. O'Donnell,Alexander P. Reiner,Stephen S. Rich,Mark J. Rieder,Michael J. Bamshad,Deborah A. Nickerson +21 more
TL;DR: This analysis considering both novel, predicted functional alleles as well as known, actionable CYP alleles reveals that rare, deleterious variation contributes markedly to the overall burden of pharmacogenetic alleles within the populations considered, and that the contribution of rare variation to this burden is over three times greater in AA individuals as compared with Caucasians.
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An Increased Burden of Common and Rare Lipid-Associated Risk Alleles Contributes to the Phenotypic Spectrum of Hypertriglyceridemia
Christopher T. Johansen,Jian Wang,Matthew B. Lanktree,Adam D. McIntyre,Matthew R. Ban,Rebecca A. Martins,Brooke A. Kennedy,Reina G. Hassell,Maartje E. Visser,Stephen M. Schwartz,Benjamin F. Voight,Roberto Elosua,Veikko Salomaa,Christopher J. O'Donnell,Geesje M. Dallinga-Thie,Sonia S. Anand,Salim Yusuf,Murray W. Huff,Sekar Kathiresan,Henian Cao,Robert A. Hegele +20 more
TL;DR: In this paper, a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertrigly...
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Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis
Nora Franceschini,Frank J. A. van Rooij,Bram P. Prins,Mary F. Feitosa,Mahir Karakas,John H. Eckfeldt,Aaron R. Folsom,Jeffrey B. Kopp,Ahmad Vaez,Jeanette S. Andrews,Jens Baumert,Vesna Boraska,Linda Broer,Caroline Hayward,Julius S. Ngwa,Yukinori Okada,Ozren Polasek,Harm-Jan Westra,Ying A. Wang,Ying A. Wang,M. Fabiola Del Greco,Nicole L. Glazer,Karen Kapur,Karen Kapur,Ido P. Kema,Lorna M. Lopez,Arne Schillert,Albert V. Smith,Cheryl A. Winkler,Lina Zgaga,Lina Zgaga,Lina Zgaga,Stefania Bandinelli,Sven Bergmann,Sven Bergmann,Mladen Boban,Murielle Bochud,Y. D. Chen,Gail Davies,Abbas Dehghan,Jingzhong Ding,Angela Doering,J. Peter Durda,Luigi Ferrucci,Oscar H. Franco,Lude Franke,Grog Gunjaca,Albert Hofman,Fang-Chi Hsu,Ivana Kolcic,Aldi T. Kraja,Michiaki Kubo,Karl J. Lackner,Lenore J. Launer,Laura R. Loehr,Guo Li,Christa Meisinger,Yusuke Nakamura,Christine Schwienbacher,Christine Schwienbacher,John M. Starr,Atsushi Takahashi,Vesela Torlak,André G. Uitterlinden,Veronique Vitart,Melanie Waldenberger,Philipp S. Wild,Mirna Kirin,Tanja Zeller,Tatijana Zemunik,Qunyuan Zhang,Andreas Ziegler,Stefan Blankenberg,Eric Boerwinkle,Ingrid B. Borecki,Harry Campbell,Ian J. Deary,Timothy M. Frayling,Christian Gieger,Tamara B. Harris,Andrew A. Hicks,Wolfgang Koenig,Christopher J. O'Donnell,Christopher J. O'Donnell,Caroline S. Fox,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Alexander P. Reiner,Jerome I. Rotter,Igor Rudan,Harold Snieder,Toshihiro Tanaka,Cornelia M. van Duijn,Peter Vollenweider,Gérard Waeber,James F. Wilson,Jacqueline C.M. Witteman,Bruce H. R. Wolffenbuttel,Alan F. Wright,Qingyu Wu,Yongmei Liu,Nancy S. Jenny,Kari E. North,Janine F. Felix,Behrooz Z. Alizadeh,L. Adrienne Cupples,L. Adrienne Cupples,John R. B. Perry,Andrew P. Morris +109 more
TL;DR: A functional role is demonstrated for the most strongly associated serum albumin locus, HPN, for which Hpn knockout mice manifest low plasma albumin concentrations and initial insights are provided into the underlying genetic architecture of serum protein concentrations and their association with human disease.