C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling
Jennifer E. Ho,Wei-Yu Chen,Ming-Huei Chen,Martin G. Larson,Elizabeth L. McCabe,Susan Cheng,Susan Cheng,Anahita Ghorbani,Erin Coglianese,Valur Emilsson,Andrew D. Johnson,Stefan Walter,Stefan Walter,Nora Franceschini,Christopher J. O'Donnell,Christopher J. O'Donnell,Abbas Dehghan,Chen Lu,Daniel Levy,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher Newton-Cheh,Honghuang Lin,Janine F. Felix,Eric R. Schreiter,Eric R. Schreiter,Ramachandran S. Vasan,James L. Januzzi,Richard T. Lee,Thomas J. Wang,Thomas J. Wang,Thomas J. Wang +31 more
TL;DR: The data suggest that genetic variation in IL1RL1 can result in increased levels of sST2 and alter immune and inflammatory signaling through the ST2/IL-33 pathway.
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Von Willebrand Factor, Type 2 Diabetes Mellitus, and Risk of Cardiovascular Disease The Framingham Offspring Study
David S. Frankel,James B. Meigs,Joseph M. Massaro,Peter W.F. Wilson,Christopher J. O'Donnell,Ralph B. D'Agostino,Geoffrey H. Tofler +6 more
TL;DR: In this paper, the Von Willebrand Factor (vWF) was associated with cardiovascular disease (CVD) in participants with type 2 diabetes mellitus or insulin resistance, and the hazard ratio for CVD was 0.94 in the second quartile, 0.98 in the third, and 1.32 in the highest (P=0.04 for trend).
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Distinct metabolomic signatures are associated with longevity in humans
Susan Cheng,Susan Cheng,Martin G. Larson,Martin G. Larson,Elizabeth L. McCabe,Joanne M. Murabito,Joanne M. Murabito,Eugene P. Rhee,Jennifer E. Ho,Jennifer E. Ho,Jennifer E. Ho,Paul F. Jacques,Anahita Ghorbani,Martin Magnusson,Amanda Souza,Amy Deik,Kerry A. Pierce,Kevin Bullock,Christopher J. O'Donnell,Christopher J. O'Donnell,Olle Melander,Clary B. Clish,Ramachandran S. Vasan,Ramachandran S. Vasan,Robert E. Gerszten,Robert E. Gerszten,Thomas J. Wang +26 more
TL;DR: It is suggested that some, but not all, metabolic pathways to human longevity are dependent on modifying risk for the two most common causes of death.
Journal ArticleDOI
Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: The Framingham Heart Study ☆ ☆☆ ★
Craig R. Walsh,L. Adrienne Cupples,Daniel Levy,Douglas P. Kiel,Marian T. Hannan,Peter W. F. Wilson,Christopher J. O'Donnell +6 more
TL;DR: Noninvasive detection and quantification of atherosclerosis may be useful in identifying high-risk individuals likely to benefit from strategies aimed at preventing CHF and the possibility of a link between AAC and vascular compliance deserves further study.
Journal ArticleDOI
The Systolic Blood Pressure Difference Between Arms and Cardiovascular Disease in the Framingham Heart Study
Ido Weinberg,Philimon Gona,Philimon Gona,Christopher J. O'Donnell,Christopher J. O'Donnell,Michael R. Jaff,Joanne M. Murabito,Joanne M. Murabito +7 more
TL;DR: In this community-based cohort, an interarm systolic blood pressure difference is common and associated with a significant increased risk for future cardiovascular events, even when the absolute difference in arm systolics blood pressure is modest, which supports research to expand clinical use of this simple measurement.