C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study
M. Kyla Shea,Sarah L. Booth,Joseph M. Massaro,Paul F. Jacques,Ralph B. D'Agostino,Bess Dawson-Hughes,Jose M. Ordovas,Christopher J. O'Donnell,Sekar Kathiresan,John F. Keaney,Ramachandran S. Vasan,Ramachandran S. Vasan,Emelia J. Benjamin +12 more
TL;DR: The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation.
Journal ArticleDOI
C-Reactive Protein and Reclassification of Cardiovascular Risk in the Framingham Heart Study
Peter W.F. Wilson,Michael J. Pencina,Paul F. Jacques,Jacob Selhub,Ralph B. D'Agostino,Christopher J. O'Donnell +5 more
TL;DR: Circulating levels of CRP help to estimate risk for initial cardiovascular events and may be used most effectively in persons at intermediate risk for vascular events, offering moderate improvement in reclassification of risk.
Journal ArticleDOI
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Lia Crotti,Pim van der Harst,Patricia B. Munroe,Tamara T. Koopmann,Nona Sotoodehnia,Elizabeth J. Rossin,Elizabeth J. Rossin,Michael Morley,Xinchen Wang,Xinchen Wang,Andrew D. Johnson,Alicia Lundby,Alicia Lundby,Daniel F. Gudbjartsson,Peter A. Noseworthy,Peter A. Noseworthy,Mark Eijgelsheim,Yuki Bradford,Kirill Tarasov,Marcus Dörr,Martina Müller-Nurasyid,Annukka M. Lahtinen,Ilja M. Nolte,Albert V. Smith,Joshua C. Bis,Aaron Isaacs,Stephen Newhouse,Daniel S. Evans,Wendy S. Post,Daryl Waggott,Leo-Pekka Lyytikäinen,Andrew A. Hicks,Lewin Eisele,David Ellinghaus,Caroline Hayward,Pau Navarro,Sheila Ulivi,Toshiko Tanaka,David J. Tester,Stéphanie Chatel,Stefan Gustafsson,Stefan Gustafsson,Meena Kumari,Richard W Morris,Åsa Torinsson Naluai,Sandosh Padmanabhan,Alexander Kluttig,Bernhard Strohmer,Andrie G. Panayiotou,María Dolores Torres,Michael Knoflach,Jaroslav A. Hubacek,Kamil Slowikowski,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Runjun D. Kumar,Tamara B. Harris,Lenore J. Launer,Alan R. Shuldiner,Alan R. Shuldiner,Alvaro Alonso,Joel S. Bader,Georg Ehret,Hailiang Huang,Hailiang Huang,W. H. Linda Kao,James B. Strait,Peter W. Macfarlane,Morris Brown,Mark J. Caulfield,Nilesh J. Samani,Florian Kronenberg,Johann Willeit,J. Gustav Smith,J. Gustav Smith,J. Gustav Smith,Karin Halina Greiser,Karin Halina Greiser,Henriette E. Meyer zu Schwabedissen,Karl Werdan,Massimo Carella,Leopoldo Zelante,Susan R. Heckbert,Bruce M. Psaty,Bruce M. Psaty,Jerome I. Rotter,Ivana Kolcic,Ozren Polasek,Alan F. Wright,Maura Griffin,Mark J. Daly,Mark J. Daly,David O. Arnar,Hilma Holm,Unnur Thorsteinsdottir,Joshua C. Denny,Dan M. Roden,Rebecca L. Zuvich,Valur Emilsson,Andrew S. Plump,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Xiaoyan Yin,Xiaoyan Yin,Marco Bobbo,Adamo Pio D'Adamo,Annamaria Iorio,Gianfranco Sinagra,Angel Carracedo,Steven R. Cummings,Mike A. Nalls,Antti Jula,Kimmo Kontula,Annukka Marjamaa,Lasse Oikarinen,Markus Perola,Markus Perola,Markus Perola,Kimmo Porthan,Raimund Erbel,Per Hoffmann,Per Hoffmann,Karl-Heinz Jöckel,Hagen Kälsch,Markus M. Nöthen,Marcel den Hoed,Marcel den Hoed,Ruth J. F. Loos,Ruth J. F. Loos,Dag S. Thelle,Dag S. Thelle,Christian Gieger,Thomas Meitinger,Siegfried Perz,Annette Peters,Hanna Prucha,Moritz F. Sinner,Melanie Waldenberger,Rudolf A. de Boer,Lude Franke,Pieter A. van der Vleuten,Britt M. Beckmann,Eimo Martens,Abdennasser Bardai,Nynke Hofman,Arthur A.M. Wilde,Elijah R. Behr,Chrysoula Dalageorgou,John R. Giudicessi,Argelia Medeiros-Domingo,Julien Barc,Florence Kyndt,Vincent Probst,Alice Ghidoni,Roberto Insolia,Robert M. Hamilton,Stephen W. Scherer,Jeffrey Brandimarto,Kenneth B. Margulies,Christine E. Moravec,Fabiola Del Greco M,Christian Fuchsberger,Jeffrey R. O'Connell,Wai K. Lee,Graham Watt,Harry Campbell,Sarah H Wild,Nour Eddine El Mokhtari,Norbert Frey,Folkert W. Asselbergs,Folkert W. Asselbergs,Irene Mateo Leach,Gerjan Navis,Maarten P. van den Berg,Dirk J. van Veldhuisen,Manolis Kellis,Manolis Kellis,Bouwe P. Krijthe,Oscar H. Franco,Albert Hofman,Jan A. Kors,André G. Uitterlinden,Jacqueline C.M. Witteman,Lyudmyla Kedenko,Claudia Lamina,Ben A. Oostra,Gonçalo R. Abecasis,Edward G. Lakatta,Antonella Mulas,Marco Orru,David Schlessinger,Manuela Uda,Marcello Ricardo Paulista Markus,Uwe Völker,Harold Snieder,Tim D. Spector,Johan Ärnlöv,Johan Ärnlöv,Lars Lind,Johan Sundström,Ann-Christine Syvänen,Mika Kivimäki,Mika Kähönen,Nina Mononen,Olli T. Raitakari,Jorma S. A. Viikari,Vera Adamkova,Stefan Kiechl,Maria Brion,Andrew N. Nicolaides,Bernhard Paulweber,Johannes Haerting,Anna F. Dominiczak,Fredrik Nyberg,Fredrik Nyberg,Peter H. Whincup,Aroon D. Hingorani,Jean-Jacques Schott,Connie R. Bezzina,Erik Ingelsson,Erik Ingelsson,Luigi Ferrucci,Paolo Gasparini,James F. Wilson,Igor Rudan,Andre Franke,Thomas W. Mühleisen,Peter P. Pramstaller,Terho Lehtimäki,Andrew D. Paterson,Afshin Parsa,Yongmei Liu,Cornelia M. van Duijn,David S. Siscovick,Vilmundur Gudnason,Yalda Jamshidi,Veikko Salomaa,Stephan B. Felix,Serena Sanna,Marylyn D. Ritchie,Bruno H. Stricker,Kari Stefansson,Laurie A. Boyer,Thomas P. Cappola,Jesper V. Olsen,Kasper Lage,Peter J. Schwartz,Stefan Kääb,Aravinda Chakravarti,Michael J. Ackerman,Arne Pfeufer,Paul I.W. de Bakker,Christopher Newton-Cheh,Christopher Newton-Cheh +260 more
TL;DR: In this paper, the authors identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization.
Journal ArticleDOI
Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction
Christopher J. O'Donnell,Christopher J. O'Donnell,Maryam Kavousi,Albert V. Smith,Sharon L.R. Kardia,Sharon L.R. Kardia,Mary F. Feitosa,Shih-Jen Hwang,Yan V. Sun,Michael A. Province,Thor Aspelund,Abbas Dehghan,Udo Hoffmann,Lawrence F. Bielak,Qunyuan Zhang,Gudny Eiriksdottir,Cornelia M. van Duijn,Caroline S. Fox,Caroline S. Fox,Mariza de Andrade,Aldi T. Kraja,Sigurdur Sigurdsson,Suzette E. Elias-Smale,Joanne M. Murabito,Lenore J. Launer,Aad van der Lugt,Sekar Kathiresan,Gabriel P. Krestin,David M. Herrington,Timothy D. Howard,Yongmei Liu,Wendy S. Post,Braxton D. Mitchell,Jeffrey R. O'Connell,Haiqing Shen,Alan R. Shuldiner,David Altshuler,David Altshuler,Roberto Elosua,Veikko Salomaa,Stephen M. Schwartz,David S. Siscovick,Benjamin F. Voight,Benjamin F. Voight,Joshua C. Bis,Nicole L. Glazer,Bruce M. Psaty,Eric Boerwinkle,Gerardo Heiss,Stefan Blankenberg,Tanja Zeller,Philipp S. Wild,Renate B. Schnabel,Arne Schillert,Andreas Ziegler,Thomas Münzel,Charles C. White,Jerome I. Rotter,Mike A. Nalls,Matthijs Oudkerk,Andrew D. Johnson,Anne B. Newman,André G. Uitterlinden,Joseph M. Massaro,Julie M. Cunningham,Tamara B. Harris,Albert Hofman,Patricia A. Peyser,Ingrid B. Borecki,L. Adrienne Cupples,Vilmundur Gudnason,Jacqueline C.M. Witteman +71 more
TL;DR: SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there is suggestive associations with both Cac and MI of SNPs in additional loci.
Journal ArticleDOI
Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.
David H. McDermott,Alan M. Fong,Qiong Yang,Joan M.G. Sechler,L. Adrienne Cupples,Maya N. Merrell,Peter W.F. Wilson,Ralph B. D'Agostino,Christopher J. O'Donnell,Dhavalkumar D. Patel,Philip M. Murphy +10 more
TL;DR: In this article, the authors showed that FKN-dependent cell-cell adhesion under conditions of physiologic shear is severely reduced in cells expressing CX3CR1-M280.