C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes
Chen Yao,Brian H. Chen,Roby Joehanes,Burcak Otlu,Xiaoling Zhang,Chunyu Liu,Tianxiao Huan,Oznur Tastan,L. Adrienne Cupples,James B. Meigs,Caroline S. Fox,Jane E. Freedman,Paul Courchesne,Christopher J. O'Donnell,Peter J. Munson,Sunduz Keles,Daniel Levy +16 more
TL;DR: Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be found to be associated with CVD, these SNPs were not found to cause CVD as discussed by the authors.
Journal ArticleDOI
Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study.
Elizabeth J. Samelson,L. Adrienne Cupples,Kerry E Broe,Marian T. Hannan,Christopher J. O'Donnell,Douglas P. Kiel +5 more
TL;DR: The relation between severity of aortic calcification in middle‐age years and subsequent risk of hip fracture in women and men in the population‐based Framingham Study is examined.
Journal ArticleDOI
Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity : The Framingham Study
Roberto Elosua,Roberto Elosua,Jose M. Ordovas,L. Adrienne Cupples,Chao-Qiang Lai,Serkalem Demissie,Caroline S. Fox,Caroline S. Fox,Joseph F. Polak,Philip A. Wolf,Ralph B. D'Agostino,Christopher J. O'Donnell,Christopher J. O'Donnell +12 more
TL;DR: The rare allele of each of the APOA5 variants and the haplotype defined by the presence of the rare alleles in these four variants were each significantly associated with CCA IMT in obese participants, and these associations remained significant even after adjustment for triglycerides.
Journal ArticleDOI
Genetics of coronary artery calcification among African Americans, a meta-analysis
Mary K. Wojczynski,Mingyao Li,Lawrence F. Bielak,Kathleen F. Kerr,Alexander P. Reiner,Nathan D. Wong,Lisa R. Yanek,Liming Qu,Charles C. White,Leslie A. Lange,Jane F. Ferguson,Jing He,Taylor Young,Thomas H. Mosley,Jennifer A. Smith,Brian G. Kral,Xiuqing Guo,Quenna Wong,Santhi K. Ganesh,Susan R. Heckbert,Michael Griswold,Daniel H. O'Leary,Matthew J. Budoff,J. Jeffrey Carr,Herman A. Taylor,Herman A. Taylor,David A. Bluemke,Serkalem Demissie,Shih-Jen Hwang,Dina N. Paltoo,Joseph F. Polak,Bruce M. Psaty,Bruce M. Psaty,Diane M. Becker,Michael A. Province,Wendy S. Post,Christopher J. O'Donnell,Christopher J. O'Donnell,James G. Wilson,Tamara B. Harris,Maryam Kavousi,L. Adrienne Cupples,Jerome I. Rotter,Myriam Fornage,Lewis C. Becker,Patricia A. Peyser,Ingrid B. Borecki,Muredach P. Reilly +47 more
TL;DR: While the largest AA data resource currently available with measured CAC was assembled, it failed to identify loci for CAC at genome-wide significant levels despite having adequate power to detect alleles with moderate to large effects.
Journal ArticleDOI
Platelet Glycoprotein IIIa PlA Polymorphism, Fibrinogen, and Platelet Aggregability The Framingham Heart Study
DaLi Feng,Klaus Lindpaintner,Martin G. Larson,Christopher J. O'Donnell,Izabella Lipinska,Patrice Sutherland,Murray A. Mittleman,James E. Muller,Ralph B. D'Agostino,Daniel Levy,Geoffrey H. Tofler +10 more
TL;DR: Higher fibrinogen levels were associated with increased platelet aggregability, however, the association between fibr inogen and platelets aggregability was genotype specific, which may be responsible for the conflicting findings regarding PlA genotype and platelet aggregation.