C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
Papers
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Book ChapterDOI
Genetics of the Framingham Heart Study Population
Diddahally R. Govindaraju,L. Adrienne Cupples,William B. Kannel,Christopher J. O'Donnell,Larry D. Atwood,Ralph B. D'Agostino,Caroline S. Fox,Marty Larson,Daniel Levy,Joanne Morabito,Ramachandran S. Vasan,Greta Lee Splansky,Philip A. Wolf,Emelia J. Benjamin,Emelia J. Benjamin +14 more
TL;DR: This chapter provides an introduction to the Framingham Heart Study and the genetic research related to cardiovascular diseases conducted in this unique population.
Journal ArticleDOI
Pathogenic variants for Mendelian and complex traits in exomes of 6,517 European and African Americans: implications for the return of incidental results.
Holly K. Tabor,Holly K. Tabor,Paul L. Auer,Paul L. Auer,Seema M. Jamal,Jessica X. Chong,Joon Ho Yu,Adam S. Gordon,Timothy A. Graubert,Christopher J. O'Donnell,Stephen S. Rich,Deborah A. Nickerson,Michael J. Bamshad +12 more
TL;DR: The results demonstrate that risk alleles of potential clinical utility for both Mendelian and complex traits are detectable in every individual, and highlight the necessity of developing guidelines and policies that consider the return of results to all individuals.
Journal ArticleDOI
Calcium intake is not associated with increased coronary artery calcification: the Framingham Study
Elizabeth J. Samelson,Sarah L. Booth,Caroline S. Fox,Katherine L. Tucker,Thomas J. Wang,Udo Hoffmann,L. Adrienne Cupples,Christopher J. O'Donnell,Douglas P. Kiel +8 more
TL;DR: The evidence is not sufficient to modify current recommendations for calcium intake to protect skeletal health with respect to vascular calcification risk and the hypothesis that high calcium intake increases coronary artery calcification increases atherosclerosis burden is not supported.
Journal ArticleDOI
Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on CMR measures of LV anatomy and function
Michael L Chuang,Philimon Gona,Guillaume Leopold Theodorus Frederik Hautvast,Carol J Salton,Susan J. Blease,Susan B. Yeon,Marcel Breeuwer,Christopher J. O'Donnell,Warren J. Manning +8 more
TL;DR: Cross-sectional data from a healthy referent group of adults free of clinical cardiovascular disease demonstrated that TPM/EDV decreases with increasing age in both sexes but is not related to hypertension or obesity.
Journal ArticleDOI
Differential impact of age, sex, and hypertension on aortic atherosclerosis: the Framingham Heart Study
Noriko Oyama,Philimon Gona,Carol J Salton,Michael L Chuang,Rahul R Jhaveri,Susan J. Blease,Anya R Manning,Marc Lahiri,René M. Botnar,Daniel Levy,Martin G. Larson,Christopher J. O'Donnell,Warren J. Manning +12 more
TL;DR: In this free-living longitudinally followed cohort, subclinical aortic atherosclerosis was seen in nearly half of subjects and increased with advancing age, and HTN was associated with increased aortsic plaque burden.