C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase
TL;DR: It is indicated that pertussis toxin can reverse the inhibition of adipocyte adenylate cyclase by nonhydrolyzable GTP analogs as well as that by GTP.
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Bayesian model averaging in consumer demand systems with inequality constraints
TL;DR: In this article, a common prior on the elasticities and budget shares evaluated at average prices and income is used for both models, including equality restrictions (homogeneity, adding tip and symmetry) and inequality restrictions (monotonicity and concavity).
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A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program
Tasnim F. Imran,Tasnim F. Imran,Daniel Posner,Daniel Posner,Jacqueline Honerlaw,Jason L. Vassy,Jason L. Vassy,Rebecca J Song,Yuk-Lam Ho,Steven J. Kittner,Katherine P. Liao,Katherine P. Liao,Tianxi Cai,Tianxi Cai,Christopher J. O'Donnell,Christopher J. O'Donnell,Luc Djoussé,Luc Djoussé,David R. Gagnon,David R. Gagnon,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Peter W.F. Wilson,Kelly Cho,Kelly Cho +25 more
TL;DR: A machine-learning algorithm and a neural network approach was used to identify cases of acute ischemic stroke (AIS) from a large national database and had high specificity for identifying AIS in a nationwide electronic health-record system.
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Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease
Cavin K. Ward-Caviness,Paul S. de Vries,Paul S. de Vries,Kerri L. Wiggins,Jennifer E. Huffman,Lisa R. Yanek,Lawrence F. Bielak,Franco Giulianini,Xiuqing Guo,Marcus E. Kleber,Marcus E. Kleber,Tim Kacprowski,Tim Kacprowski,Stefan Gross,Astrid Petersman,George Davey Smith,Fernando Pires Hartwig,Fernando Pires Hartwig,Jack Bowden,Gibran Hemani,Martina Muller-Nuraysid,Konstantin Strauch,Wolfgang Koenig,Wolfgang Koenig,Melanie Waldenberger,Thomas Meitinger,Nathan Pankratz,Eric Boerwinkle,Eric Boerwinkle,Weihong Tang,Yi-Ping Fu,Andrew D. Johnson,Ci Song,Moniek P.M. de Maat,André G. Uitterlinden,Oscar H. Franco,Jennifer A. Brody,Barbara McKnight,Yii-Der Ida Chen,Bruce M. Psaty,Bruce M. Psaty,Rasika A. Mathias,Diane M. Becker,Patricia A. Peyser,Jennifer A. Smith,Suzette J. Bielinski,Paul M. Ridker,Kent D. Taylor,Jie Yao,Russell P. Tracy,Graciela Delgado,Stella Trompet,Stella Trompet,Naveed Sattar,J. Wouter Jukema,Lewis C. Becker,Sharon L.R. Kardia,Jerome I. Rotter,Winfried März,Winfried März,Winfried März,Marcus Dörr,Daniel I. Chasman,Abbas Dehghan,Abbas Dehghan,Christopher J. O'Donnell,Nicholas L. Smith,Nicholas L. Smith,Annette Peters,Alanna C. Morrison +69 more
TL;DR: Results indicate that even with large sample sizes and multi-variant approaches MR analyses still cannot exclude the null when estimating the causal effect of fibrinogen on CHD, but that any potential causal effect is likely to be much smaller than observed in epidemiological studies.
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The artefacts of death: CT post-mortem findings.
TL;DR: It is vital that the artefacts associated with the process of dying and decompositional changes are recognised to avoid misdiagnosis.