C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Right Ventricular Volumes and Systolic Function by Cardiac Magnetic Resonance and the Impact of Sex, Age, and Obesity in a Longitudinally Followed Cohort Free of Pulmonary and Cardiovascular Disease: The Framingham Heart Study.
Murilo Foppa,Garima Arora,Philimon Gona,Arman Ashrafi,Carol J Salton,Susan B. Yeon,Susan J. Blease,Daniel Levy,Christopher J. O'Donnell,Warren J. Manning,Michael L Chuang +10 more
TL;DR: Sex, age, height, body mass index, and heart rate account for most of the variability in RV volumes and function in this community-dwelling, longitudinally followed cohort free of clinical cardiovascular and pulmonary disease.
Journal ArticleDOI
A common biological basis of obesity and nicotine addiction
Thorgeir E. Thorgeirsson,Daniel F. Gudbjartsson,Patrick Sulem,Søren Besenbacher,Søren Besenbacher,Unnur Styrkarsdottir,Gudmar Thorleifsson,G B Walters,Helena Furberg,Patrick F. Sullivan,Jonathan Marchini,Jonathan Marchini,Mark I. McCarthy,Mark I. McCarthy,Valgerdur Steinthorsdottir,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Ida Surakka,Ida Surakka,Jacqueline M. Vink,Najaf Amin,Frank Geller,Thorunn Rafnar,Tõnu Esko,Tõnu Esko,Stefan Walter,Christian Gieger,Rajesh Rawal,Massimo Mangino,Inga Prokopenko,Inga Prokopenko,Reedik Mägi,Reedik Mägi,Reedik Mägi,Kaisu Keskitalo,Iris H Gudjonsdottir,Solveig Gretarsdottir,Hreinn Stefansson,Yurii S. Aulchenko,Mari Nelis,Mari Nelis,Katja K.H. Aben,Martin den Heijer,Nicole Soranzo,Nicole Soranzo,Ana M. Valdes,Claire J. Steves,André G. Uitterlinden,Albert Hofman,Anke Tönjes,Peter Kovacs,Jouke-Jan Hottenga,Gonneke Willemsen,Nicole Vogelzangs,Angela Döring,Norbert Dahmen,Norbert Dahmen,Barbara Nitz,Samuli Ripatti,Samuli Ripatti,M. Perola,M. Perola,Johannes Kettunen,Anna-Liisa Hartikainen,Anna-Liisa Hartikainen,Anneli Pouta,Jaana Laitinen,Matti Isohanni,Matti Isohanni,Shen Huei-Yi,Shen Huei-Yi,Maxine Allen,Maria Krestyaninova,Alistair S. Hall,John R. Thompson,Hogni Oskarsson,Thorarinn Tyrfingsson,Lambertus A. Kiemeney,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Veikko Salomaa,Michael Stumvoll,Tim D. Spector,H.-Erich Wichmann,Andres Metspalu,Andres Metspalu,Nilesh J. Samani,Brenda W.J.H. Penninx,Ben A. Oostra,Dorret I. Boomsma,Henning Tiemeier,Cornelia M. van Duijn,Jaakko Kaprio,Jaakko Kaprio,Jeffrey R. Gulcher,Yunjung Kim,Jennifer Dackor,Eric Boerwinkle,Nora Franceschini,Diego Ardissino,Luisa Bernardinelli,Luisa Bernardinelli,Pier Mannuccio Mannucci,Francesco Mauri,Piera Angelica Merlini,Devin Absher,Themistocles L. Assimes,Stephen P. Fortmann,Carlos Iribarren,Joshua W. Knowles,Thomas Quertermous,Luigi Ferrucci,Toshiko Tanaka,Joshua C. Bis,Curt D. Furberg,Talin Haritunians,Barbara McKnight,Bruce M. Psaty,Bruce M. Psaty,Kent D. Taylor,Evan L. Thacker,Peter Almgren,Leif Groop,Claes Ladenvall,Michael Boehnke,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Jaakko Tuomilehto,Jaakko Tuomilehto,Emelia J. Benjamin,Shih-Jen Hwang,Daniel Levy,Sarah R. Preis,Ramachandran S. Vasan,Jubao Duan,Pablo V. Gejman,Douglas F. Levinson,Alan R. Sanders,Jianxin Shi,Esther H. Lips,James McKay,Antonio Agudo,Luigi Barzan,Vladimir Bencko,Simone Benhamou,Xavier Castellsagué,Cristina Canova,David I. Conway,Eleonora Fabianova,Lenka Foretova,Vladimir Janout,Claire M. Healy,Ivana Holcatova,Kristina Kjærheim,Pagona Lagiou,Jolanta Lissowska,Ray Lowry,Tatiana V. Macfarlane,Dana Mates,Lorenzo Richiardi,Peter Rudnai,Neonilia Szeszenia-Dabrowska,David Zaridze,Ariana Znaor,Mark Lathrop,Mark Lathrop,Paul Brennan,Stefania Bandinelli,Timothy M. Frayling,Jack M. Guralnik,Yuri Milaneschi,John R. B. Perry,David Altshuler,David Altshuler,Roberto Elosua,S. Kathiresan,S. Kathiresan,Gavin Lucas,Olle Melander,Christopher J. O'Donnell,Stephen M. Schwartz,Benjamin F. Voight,Benjamin F. Voight,Johannes H. Smit,Johannes H. Smit,Eco J. C. de Geus,Stephen J. Chanock,Stephen J. Chanock,Fangyi Gu,Fangyi Gu,Susan E. Hankinson,David J. Hunter,David J. Hunter,Daniel I. Chasman,Brendan M. Everett,Brendan M. Everett,Brendan M. Everett,Guillaume Paré,Guillaume Paré,Paul M. Ridker,Ming D. Li,Hermine H. Maes,Janet Audrain-McGovern,Danielle Posthuma,Laura M. Thornton,Caryn Lerman,Jed E. Rose,John P. A. Ioannidis,John P. A. Ioannidis,Peter Kraft,Danyu Lin,Danyu Lin,Jason S. Liu,Federica Tozzi,Dawn M. Waterworth,Sreekumar G. Pillai,Pierandrea Muglia,Lefkos T. Middleton,Wade H. Berrettini,Christopher W. Knouff,Xin Yuan,Gérard Waeber,Peter Vollenweider,Martin Preisig,Nicholas J. Wareham,Jing Hua Zhao,Ruth J. F. Loos,Inês Barroso,Kay-Tee Khaw,Scott M. Grundy,Philip J. Barter,Robert W. Mahley,Antero Kesäniemi,Ruth McPherson,Ruth McPherson,John B. Vincent,John Strauss,James L. Kennedy,Anne Farmer,Peter McGuffin,Richard O. Day,Keith Matthews,Per Bakke,Amund Gulsvik,Susanne Lucae,Marcus Ising,T. Brueckl,S. Horstmann,Joachim Heinrich,Claudia Lamina,Claudia Lamina,Ozren Polasek,Lina Zgaga,Jennifer E. Huffman,Susan Campbell,Jaspal S. Kooner,John C. Chambers,Mary Susan Burnett,Joe Devaney,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Stephen E. Epstein,James F. Wilson,Sarah H. Wild,Harry Campbell,Veronique Vitart,Muredach P. Reilly,Mingyao Li,Liming Qu,Robert L. Wilensky,William H. Matthai,Hakon Hakonarson,Daniel J. Rader,Andre Franke,Michael Wittig,Arne Schäfer,Manuela Uda,Antonio Terracciano,Xiangjun Xiao,Fabio Busonero,Paul Scheet,David Schlessinger,David St Clair,Dan Rujescu,Gonçalo R. Abecasis,Hans J. Grabe,Alexander Teumer,Henry Völzke,Astrid Petersmann,Ulrich John,Igor Rudan,Caroline Hayward,Alan F. Wright,Ivana Kolcic,Benjamin J. Wright,Anthony J. Balmforth,Carl A. Anderson,Tariq Ahmed,Christopher G. Mathew,Miles Parkes,Jack Satsangi,Mark J. Caulfield,Patricia B. Munroe,Martin Farrall,Anna F. Dominiczak,Jane Worthington,Wendy Thomson,Steve Eyre,Anne Barton,Vincent Mooser,Clyde Francks +316 more
TL;DR: The results strongly point to a common biological basis of the regulation of theregulation of the authors' appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity, and the effect of single-nucleotide polymorphisms affecting body mass index (BMI).
Journal ArticleDOI
Predicting Stroke Through Genetic Risk Functions The CHARGE Risk Score Project
Carla A. Ibrahim-Verbaas,Myriam Fornage,Joshua C. Bis,Seung Hoan Choi,Seung Hoan Choi,Bruce M. Psaty,Bruce M. Psaty,James B. Meigs,Madhu Rao,Mike A. Nalls,João D. Fontes,João D. Fontes,Christopher J. O'Donnell,Sekar Kathiresan,Sekar Kathiresan,Georg Ehret,Georg Ehret,Georg Ehret,Caroline S. Fox,Caroline S. Fox,Rainer Malik,Martin Dichgans,Helena Schmidt,Jari Lahti,Susan R. Heckbert,Thomas Lumley,Kenneth Rice,Jerome I. Rotter,Kent D. Taylor,Aaron R. Folsom,Eric Boerwinkle,Wayne D. Rosamond,Eyal Shahar,Rebecca F. Gottesman,Peter J. Koudstaal,Najaf Amin,Renske G. Wieberdink,Abbas Dehghan,Albert Hofman,André G. Uitterlinden,Anita L. DeStefano,Stéphanie Debette,Luting Xue,Luting Xue,Alexa S. Beiser,Alexa S. Beiser,Philip A. Wolf,Philip A. Wolf,Charles DeCarli,M. Arfan Ikram,Sudha Seshadri,Sudha Seshadri,Thomas H. Mosley,W. T. Longstreth,Cornelia M. van Duijn,Lenore J. Launer +55 more
TL;DR: The single-nucleotide polymorphisms associated with stroke and its risk factors result only in a small improvement in prediction of future stroke compared with the classical epidemiological risk factors for stroke.
Journal ArticleDOI
An exome array study of the plasma metabolome
Eugene P. Rhee,Qiong Yang,Bing Yu,Xuan Liu,Susan Cheng,Amy Deik,Kerry A. Pierce,Kevin Bullock,Jennifer E. Ho,Daniel Levy,Jose C. Florez,S. Kathiresan,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Clary B. Clish,Thomas J. Wang,Eric Boerwinkle,Eric Boerwinkle,Christopher J. O'Donnell,Robert E. Gerszten +21 more
TL;DR: This work analyzes the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study and replication in 1,528 participants of the Atherosclerosis Risk in Communities Study to provide a more complete picture of the genetic architecture of the plasma metabolome.
Journal ArticleDOI
Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults
Nicholas L. Smith,Jennifer E. Huffman,David P. Strachan,Jie Huang,Abbas Dehghan,Stella Trompet,Lorna M. Lopez,So-Youn Shin,Jens Baumert,Veronique Vitart,Joshua C. Bis,Sarah H. Wild,Ann Rumley,Qiong Yang,André G. Uitterlinden,David J. Stott,Gail Davies,Angela M. Carter,Barbara Thorand,Ozren Polasek,Barbara McKnight,Harry Campbell,Alicja R Rudnicka,Ming-Huei Chen,Brendan M. Buckley,Sarah E. Harris,Annette Peters,Drazen Pulanic,Thomas Lumley,Anton J. M. de Craen,David C. Liewald,Christian Gieger,Susan Campbell,Ian Ford,Alan J. Gow,Michelle Luciano,David J. Porteous,Xiuqing Guo,Naveed Sattar,Albert Tenesa,Mary Cushman,P. Eline Slagboom,Peter M. Visscher,Tim D. Spector,Thomas Illig,Igor Rudan,Igor Rudan,Edwin G. Bovill,Alan F. Wright,Wendy L. McArdle,Geoffrey H. Tofler,Albert Hofman,Rudi G. J. Westendorp,John M. Starr,Peter J. Grant,Mahir Karakas,Nicholas D. Hastie,Bruce M. Psaty,James F. Wilson,Gordon D.O. Lowe,Christopher J. O'Donnell,Jacqueline C. M. Witteman,J. Wouter Jukema,Ian J. Deary,Nicole Soranzo,Nicole Soranzo,Wolfgang Koenig,Caroline Hayward +67 more
TL;DR: Three genes were associated with fibrin D-dimer levels, and the F3 association was the strongest, and has not been previously reported.