C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis
Kevin Teo,Kushala W M Abeysekera,Leon A. Adams,Leon A. Adams,Elmar Aigner,Quentin M. Anstee,Quentin M. Anstee,Jesus M. Banales,Rajarshi Banerjee,Priyadarshi Basu,Thomas Berg,Pallav Bhatnagar,Stephan Buch,Ali Canbay,Sonia Caprio,Ankita Chatterjee,Yii-Der Ida Chen,Abhijit Chowdhury,Ann K. Daly,Christian Datz,Dana de Gracia Hahn,Johanna K. DiStefano,Jiawen Dong,Amedine Duret,Anita Vreugdenhil,A. Alisi,Piotr Socha,Wojciech Jańczyk,Ulrich Baumann,Sanjay Rajwal,Indra van Mourik,Florence Lacaille,Myriam Dabbas,Deirdre A. Kelly,Valerio Nobili,Connor A. Emdin,Madison Fairey,Glenn S. Gerhard,Gudny Eiriksdottir,Melissa E. Garcia,Vilmundur Gudnason,Tamara B. Harris,Lauren J. Kim,Lenore J. Launer,Michael A. Nalls,Albert V. Smith,Jeanne M. Clark,Ruben Hernaez,W.H. Linda Kao,B. D. Mitchell,A. R. Shuldiner,Laura M. Yerges-Armstrong,Ingrid B. Borecki,J. Jeffrey Carr,Mary F. Feitosa,Jun Wu,Johannah L. Butler,Caroline S. Fox,Joel N. Hirschhorn,Udo Hoffmann,Shih-Jen Hwang,Joseph M. Massaro,Christopher J. O'Donnell,Cameron D. Palmer,Dushyant V. Sahani,Elizabeth K. Speliotes,Xiuqing Guo,Jochen Hampe,Matthew Hickman,L Heintz,Christian A. Hudert,Harriet Hunter,Matt Kelly,Julia Kozlitina,Marcin Krawczyk,Marcin Krawczyk,Frank Lammert,Claudia Langenberg,Joel E. Lavine,Lin Li,Hong Kai Lim,Rohit Loomba,Panu K. Luukkonen,Panu K. Luukkonen,Panu K. Luukkonen,Phillip E. Melton,Phillip E. Melton,Phillip E. Melton,Trevor A. Mori,Nicholette D. Palmer,Constantinos A. Parisinos,Sreekumar G. Pillai,Faiza Qayyum,Matthias C. Reichert,Stefano Romeo,Stefano Romeo,Stefano Romeo,Jerome I. Rotter,Yu Ri Im,Nicola Santoro,Nicola Santoro,Clemens Schafmayer,Stefan Stender,Felix Stickel,Christopher D. Still,Pavel Strnad,Kent D. Taylor,Anne Tybjærg-Hansen,Giuseppina Rosaria Umano,Giuseppina Rosaria Umano,Mrudula Utukuri,Luca Valenti,Luca Valenti,Lynne E. Wagenknecht,Nicholas J. Wareham,Richard M. Watanabe,Julia Wattacheril,Hanieh Yaghootkar,Hannele Yki-Järvinen,Hannele Yki-Järvinen,Kendra A. Young,Jake P. Mann +121 more
TL;DR: This study validates rs641738C>T near MBOAT7 as a risk factor for the presence and severity of NAFLD in individuals of European descent and takes data from over 40 published studies to find that this variant is linked to more severe fatty liver disease.
Journal ArticleDOI
Genetic variation associated with circulating monocyte count in the eMERGE Network
David R. Crosslin,Andrew McDavid,Noah Weston,Xiuwen Zheng,Eugene Hart,Mariza de Andrade,Iftikhar J. Kullo,Catherine A. McCarty,Kimberly F. Doheny,Elizabeth W. Pugh,Abel N. Kho,M. Geoffrey Hayes,Marylyn D. Ritchie,Alexander Saip,Dana C. Crawford,Paul K. Crane,Katherine M. Newton,David Carrell,Carlos J. Gallego,Mike A. Nalls,Rongling Li,Daniel B. Mirel,Andrew Crenshaw,David Couper,Toshiko Tanaka,Frank J. A. van Rooij,Ming-Huei Chen,Ming-Huei Chen,Albert V. Smith,Neil A. Zakai,Qiong Yango,Qiong Yango,Melissa Garcia,Yongmei Liu,Thomas Lumley,Aaron R. Folsom,Alexander P. Reiner,Janine F. Felix,Abbas Dehghan,James G. Wilson,Joshua C. Bis,Caroline S. Fox,Caroline S. Fox,Nicole L. Glazer,L. Adrienne Cupples,L. Adrienne Cupples,Josef Coresh,Gudny Eiriksdottir,Vilmundur Gudnason,Stefania Bandinelli,Timothy M. Frayling,Aravinda Chakravarti,Cornelia M. van Duijn,David Melzer,Daniel Levy,Eric Boerwinkle,Andrew Singleton,Dena G. Hernandez,Dena G. Hernandez,Dan L. Longo,Jacqueline C.M. Witteman,Bruce M. Psaty,Bruce M. Psaty,Luigi Ferrucci,Tamara B. Harris,Christopher J. O'Donnell,Christopher J. O'Donnell,Santhi K. Ganesh,Eric B. Larson,Christopher S. Carlson,Gail P. Jarvik +70 more
TL;DR: A joint and ancestry-stratified genome-wide association analyses to identify variants specifically associated with monocyte count in 11 014 subjects in the electronic Medical Records and Genomics Network identify novel associations in the chromosome 16 interferon regulatory factor 8 gene.
Journal ArticleDOI
Stroke genetics informs drug discovery and risk prediction across ancestries
Aniket Mishra,Rainer Malik,Tsuyoshi Hachiya,Tuuli Jürgenson,Shinichi Namba,Daniel Posner,Frederick K. Kamanu,Masaru Koido,Mingyang Shi,Yunye He,Marios K. Georgakis,Ilana Caro,Kristi Krebs,Yi-Ching Liaw,Felix Vaura,Kuang Lin,Bendik S. Winsvold,Vinodh Srinivasasainagendra,Livia Parodi,Hee-Joon Bae,Ganesh Chauhan,Michael Chong,Liisa Tomppo,Rufus Akinyemi,Gennady V. Roshchupkin,Naomi Habib,Yon Ho Jee,Jesper Qvist Thomassen,Vida Abedi,Jara Cárcel-Márquez,Marianne Nygaard,Hampton L. Leonard,Chaojie Yang,Ekaterina Yonova-Doing,Maria J. Knol,Adam J. Lewis,Renae Judy,Tetsuro Ago,Philippe Amouyel,N. Armstrong,Mark K Bakker,Traci M. Bartz,David A. Bennett,Joshua C. Bis,Constance Bordes,Sigrid Børte,Anael Cain,Paul M. Ridker,Kelly Cho,Zhengming Chen,Carlos Cruchaga,John W. Cole,Rafael de Cid,Matthias Endres,Mirjam I. Geerlings,Natalie C. Gasca,Vilmundur Gudnason,Jun Hata,Jiang He,Alicia K Heath,Yuk-Lam Ho,Aki S. Havulinna,Jemma C. Hopewell,Hyacinth I. Hyacinth,Michael Inouye,Mina A. Jacob,Christina Jeon,Christina Jern,Masahiro Kamouchi,Keith L. Keene,Takanari Kitazono,Steven J. Kittner,Takahiro Konuma,Amit Kumar,Paul Lacaze,Lenore J. Launer,Keon-Joo Lee,Kaido Lepik,Jiang Li,Liming Li,Ani Manichaikul,Hugh S. Markus,Nicholas A Marston,Thomas Meitinger,Braxton D. Mitchell,Felipe A. Montellano,Takayuki Morisaki,Thomas H. Mosley,Mike A. Nalls,Martin O'Donnell,Yukinori Okada,N. Charlotte Onland-Moret,Bruce Ovbiagele,Annette Peters,Bruce M. Psaty,Stephen S. Rich,Jonathan Rosand,Marc S. Sabatine,Ralph L. Sacco,Danish Saleheen,Else Charlotte Sandset,Veikko Salomaa,Muralidharan Sargurupremraj,Makoto Sasaki,Claudia L. Satizabal,Carsten Oliver Schmidt,Atsushi Shimizu,Nicholas L. Smith,Kelly L. Sloane,Yoichi Sutoh,Yan V. Sun,Kozo Tanno,Steffen Tiedt,Turgut Tatlisumak,Nuria P. Torres-Aguila,Hemant K. Tiwari,David-Alexandre Trégouët,Stella Trompet,Anil M. Tuladhar,Anne Tybjærg-Hansen,Riina Vibo,Shefali S. Verma,Kerri L. Wiggins,Patrik Wennberg,Daniel Woo,Peter W.F. Wilson,Huichun Xu,Qiong Yang,Kyungheon Yoon,Jin-Moo Lee,James F. Meschia,Wei Min Chen,Michèle M. Sale,Alan B. Zonderman,Michele K. Evans,James F. Wilson,Adolfo Correa,Matthew Traylor,Cathryn M. Lewis,Cara L. Carty,Jeffrey Haessler,Carl D. Langefeld,Rebecca F. Gottesman,Kristine Yaffe,Yong Mei Liu,Charles Kooperberg,Leslie A. Lange,Karen L. Furie,Donna K. Arnett,Oscar R. Benavente,Raji P. Grewal,Leema Reddy Peddareddygari,Kristian Hveem,S. Lindstrom,Lu Wang,Erin N. Smith,William J. Gordon,Astrid van Hylckama Vlieg,Mariza de Andrade,Jennifer A. Brody,Jack Pattee,Ben Michael Brumpton,Pierre Suchon,Ming-Huei Chen,Kelly A. Frazer,Constance Turman,Marine Germain,James W. MacDonald,S. Braekkan,Sebastian M. Armasu,Nathan Pankratz,Rebecca D. Jackson,Jonas B. Nielsen,Franco Giulianini,Marja Puurunen,Manal Ibrahim,Susan R. Heckbert,Theo K. Bammler,Bryan M. McCauley,Kent D. Taylor,James S. Pankow,Alexander P. Reiner,Maiken Elvestad Gabrielsen,Jean-François Deleuze,Christopher J. O'Donnell,Jihye Kim,Barbara McKnight,Peter Kraft,J. D. Hansen,Frits R. Rosendaal,John A. Heit,Weihong Tan,Pierre-Emmanuel Morange,Andrew Johnson,Christopher Kabrhel,Ewoud J. van Dijk,Peter J. Koudstaal,Gert-Jan Luijckx,Paul J. Nederkoorn,Robert J. van Oostenbrugge,Marieke C.H. de Visser,Marieke J.H. Wermer,L. Jaap Kappelle,Tõnu Andres Reedik Mari Esko Metspalu Mägi Nelis,Tõnu Esko,Andres Metspalu,Reedik Mägi,Mari Nelis,Marguerite R. Irvin,F.E. De Leeuw,Christopher R Levi,Jane Maguire,Jordi Jimenez-Conde,Pankaj Sharma,Cathie Sudlow,Kristiina Rannikmäe,Reinhold Schmidt,Agnieszka Slowik,Joanna Pera,Vincent Thijs,Arne Lindgren,Andreea Ilinca,Olle Melander,Gunnar Engström,Kathryn M. Rexrode,Peter M. Rothwell,Tara M. Stanne,Julie A. Johnson,John Danesh,Adam S. Butterworth,Laura Heitsch,Giorgio B. Boncoraglio,Michiaki Kubo,Alessandro Pezzini,Arndt Rolfs,Anne-Katrin Giese,David R. Weir,Owen A. Ross,Robert Lemmons,Martin Soderholm,Mary Cushman,K. Joo,Caitrin W. McDonough,Steven Bell,Birgit Linkohr,Tsong-Hai Lee,Jukka Putaala,Christopher D. Anderson,Oscar L. Lopez,Xueqiu Jian,Ulf Schminke,Natalia Cullell,Pilar Delgado,Laura Ibanez,Jerzy Krupinski,Vasileios-Arsenios Lioutas,Koichi Matsuda,Joan Antoni Martín Montaner,Elena Muiño,Jaume Roquer,Chloé Sarnowski,Naveed Sattar,Gerli Sibolt,Alexander Teumer,Loes C.A. Rutten-Jacobs,Masahiro Kanai,Solveig Gretarsdottir,Natalia S. Rost,Salim Yusuf,Peter Almgren,Hakan Ay,Steve Bevan,Robert Brown,Caty Carrera,Julie E. Buring,Wei-Min Chen,Ioana Cotlarciuc,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Stefan Gustafsson,A Hassan,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Erik Ingelsson,Tamara B. Harris,Brett M. Kissela,Dawn Kleindorfer,Claudia Langenberg,Robin Lemmens,Didier Leys,Wei-Yu Lin,Erik Lorentzen,Patrik K. E. Magnusson,Patrick F. McArdle,Sara L. Pulit,Kenneth Rice,Saori Sakaue,Bishwa Raj Sapkota,Christian Tanislav,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Christophe Tzourio,Cornelia M. van Duijn,M. Walters,Nicholas J. Wareham,Najaf Amin,Hugo J. Aparicio,John Attia,Alexa S. Beiser,Claudine Berr,Mariana Bustamante,Valeria Caso,Seung Hoan Choi,Ayesha Chowhan,Jean-François Dartigues,Hossein Delavaran,Marcus Dörr,Ian J. Ford,Wander S. Gurpreet,Anders Hamsten,Atsushi Hozawa,Martin Ingelsson,Motoki Iwasaki,Sara Kaffashian,Lalit Kalra,Olafur Kjartansson,Manja Kloss,Daniel L. Labovitz,Cathy C. Laurie,Linxin Li,Lars Lind,Cecilia M. Lindgren,Hirata Makoto,Naoko Minegishi,Andrew P. Morris,Martina Müller-Nurasyid,Bo Norrving,Soichi Ogishima,Eugenio Parati,Nancy L. Pedersen,Markus Perola,Pekka Jousilahti,Silvana Pileggi,Raquel Rabionet,Iolanda Riba-Llena,Marta Ribasés,Jose R. Romero,Anthony Rudd,Antti-Pekka Sarin,Ralhan Sarju,Mamoru Satoh,Norie Sawada,Asgeir Sigurdsson,O. Colin Stine,David J. Stott,Konstantin Strauch,Takako Takai,Hideo Tanaka,Emmanuel Touzé,Shoichiro Tsugane,André G. Uitterlinden,Einar M. Valdimarsson,S. J. van der Lee,Kenji Wakai,Stephen E. Williams,Charles D.A. Wolfe,Quenna Wong,Taiki Yamaji,Dharambir K. Sanghera,Kari Stefansson,Nicolas Martinez-Majander,Kenji Sobue,Carolina Soriano-Tárraga,Henry Völzke,Onoja Akpa,Fred Stephen Sarfo,Albert Akpalu,Reginald Obiako,Kolawole Wahab,Godwin Osaigbovo,Lukman Owolabi,Morenikeji A. Komolafe,Carolyn Jenkins,Oyedunni Arulogun,Godwin Ogbole,Abiodun M. Adeoye,Joshua O. Akinyemi,Atinuke M Agunloye,Adekunle Fakunle,Ezinne Uvere,Abimbola Olalere,Olayinka J. Adebajo,Junshi Chen,Robert Clarke,Rory Collins,Yu Guo,Chen Wang,Jun Lv,Richard Peto,Yiping Shen,Zammy Fairhurst-Hunter,Michael Hill,Alfred Pozarickij,Dan Schmidt,Becky Stevens,Iain Turnbull,Canqing Yu,Quentin Leslie E. Le Grand Ferreira,Quentin Le Grand,Leslie Ecker Ferreira,Akiko Yoishinori Nagai Murakami,Akiko Nagai,Yoishinori Murakami,M. van Vugt,Eric J. Shiroma,Sigurdur Sigurdsson,Mohsen Ghanbari,Eric Boerwinkle,Bernard Fongang,Ruiqi Wang,Mohammad Kamran Ikram,Uwe Völker,Philip L. De Jager,Børge G. Nordestgaard,Karlijn F. de Laat,Anouk G.W. van Norden,Paul L.M. de Kort,Sarah E. Vermeer,P. J. A. M. Brouwers,Rob A.R. Gons,Tom den Heijer,Gert W. van Dijk,Frank G. van Rooij,Anne Hege Aamodt,Anne Heidi Skogholt,Cristen J. Willer,Ingrid Heuch,Knut Hagen,Lars G. Fritsche,Linda M. Pedersen,Hanne Ellekjær,Wei Zhou,Amy E Martinsen,Espen Saxhaug Kristoffersen,Laurent F. Thomas,Christoph Stefan Kathrin Kleinschnitz Frantz Ungethüm,Christoph Kleinschnitz,Stefan Frantz,K. Ungethüm,Cristina Gallego-Fabrega,Miquel Lledós,Laia Llucià-Carol,Tomás Sobrino,Francisco Campos,José Castillo,M. Freijo,Juan F. Arenillas,Victor Obach,José Alvarez-Sabín,Carlos A. Molina,Marc Ribó,Lucia Muñoz-Narbona,E. López-Cancio,Mónica Millán,Rosa Díaz-Navarro,Cristofol Vives-Bauza,G. Serrano-Heras,Tomás Segura,Rajat Dhar,Raquel Delgado-Mederos,Luis Prats-Sánchez,Pol Camps-Renom,Natalia Blay,Lauro Sumoy,Joan Martí-Fàbregas,Peter Gorm B. Marianne Shoaib Pia R. Schnohr Jensen Benn Afzal Kamstrup,Peter Schnohr,Gorm B. Jensen,Marianne Benn,Shoaib Afzal,Pia R. Kamstrup,Jessica Sander W. Jet M. J. van Setten van der Laan Vonk,Jessica van Setten,Sander W. van der Laan,Jet M.J. Vonk,Bong-Jo Kim,Sami Marjaana Janne Curtze Tiainen Kinnunen,S. Curtze,Marjaana Tiainen,Janne Kinnunen,Vilas Yun Ju Chengran Florence Simon Menon Sung Yang Saillour-Glenisson Gravel,Vilas Menon,Yun Ju Sung,Chengran Yang,Florence Saillour-Glénisson,Simon Gravel,N. C. A. K. Onland-Moret Heath,Iona Y. Millwood,Christian Gieger,Toshiharu Ninomiya,Hans J. Grabe,J. Wouter Jukema,Ina Rissanen,Daniel Strbian,Young-Jin Kim,Pei-Hsin Chen,E. Mayerhofer,Joanna M. M. Howson,Hieab H.H. Adams,Sylvia Wassertheil-Smoller,Kaare Christensen,M. Arfan Ikram,Tatjana Rundek,Bradford B. Worrall,Mark Lathrop,Moeen Riaz,Eleanor M. Simonsick,Janika Kõrv,Paulo Henrique Condeixa de França,Ramin Zand,Kameshwar Prasad,Ruth Frikke-Schmidt,Thomas G. Liman,Karl Georg Haeusler,Ynte M. Ruigrok,Peter U. Heuschmann,W. T. Longstreth,Keum Ji Jung,L. Bastarache,Guillaume Paré,Scott M. Damrauer,Daniel I. Chasman,Jerome I. Rotter,John-Anker Zwart,Teemu J. Niiranen,Myriam Fornage,Yung-Po Liaw,Sudha Seshadri,Israel Fernandez-Cadenas,Robin G. Walters,Christian T. Ruff,Mayowa O. Owolabi,Jennifer E. Huffman,Lili Milani,Yoichiro Kamatani,Martin Dichgans,Stéphanie Debette +551 more
TL;DR: In this article , a cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses.
Journal ArticleDOI
Electrocardiographic and clinical predictors of acute myocardial infarction in patients with unstable angina pectoris.
Donald M. Lloyd-Jones,Carlos A. Camargo,Carlos A. Camargo,Pablo Lapuerta,Robert P. Giugliano,Christopher J. O'Donnell +5 more
TL;DR: Electrocardiographic and clinical variables can help immediately identify those at high risk for AMI at presentation and a prediction rule was developed that was validated in this cohort of patients.
Journal ArticleDOI
Factor VII Gene Polymorphism, Factor VII Levels, and Prevalent Cardiovascular Disease The Framingham Heart Study
DaLi Feng,Geoffrey H. Tofler,Martin G. Larson,Christopher J. O'Donnell,Izabella Lipinska,Christian Schmitz,Patrice Sutherland,Michael T. Johnstone,James E. Muller,Ralph B. D'Agostino,Daniel Levy,Klaus Lindpaintner +11 more
TL;DR: In the Framingham Heart Study, the Arg/Gln polymorphism was significantly associated with factor VII antigen levels, and the strength of the association suggests that genetic variation plays an important role in determining factor VII levels.