C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Genome-wide association study of peripheral artery disease in the Million Veteran Program
Derek Klarin,Julie Lynch,Julie Lynch,Krishna G. Aragam,Krishna G. Aragam,Mark Chaffin,Themistocles L. Assimes,Themistocles L. Assimes,Jie Huang,Kyung Min Lee,Kyung Min Lee,Qing Shao,Jennifer E. Huffman,Pradeep Natarajan,Shipra Arya,Shipra Arya,Aeron Small,Aeron Small,Yan V. Sun,Marijana Vujkovic,Marijana Vujkovic,Matthew S. Freiberg,Lu Wang,Jinbo Chen,Danish Saleheen,Danish Saleheen,Jennifer Lee,Jennifer Lee,Donald R. Miller,Donald R. Miller,Peter D. Reaven,Patrick R. Alba,Patrick R. Alba,Olga V. Patterson,Olga V. Patterson,Scott L. DuVall,Scott L. DuVall,William E. Boden,Joshua A. Beckman,J. Michael Gaziano,John Concato,John Concato,Daniel J. Rader,Kelly Cho,Kyong-Mi Chang,Kyong-Mi Chang,Peter W.F. Wilson,Christopher J. O'Donnell,Sekar Kathiresan,Sekar Kathiresan,VA Million Veteran Program,VA Million Veteran Program,Philip S. Tsao,Philip S. Tsao,Scott M. Damrauer,Scott M. Damrauer +55 more
TL;DR: A genome-wide association study using electronic health record data in the Million Veteran Program uncovers new genetic loci associated specifically with peripheral artery disease, as compared to stroke or coronary artery disease.
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Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.
Roby Joehanes,Roby Joehanes,Roby Joehanes,Xiaoling Zhang,Xiaoling Zhang,Tianxiao Huan,Chen Yao,Saixia Ying,Quang Tri Nguyen,Cumhur Y Demirkale,Michael Feolo,Nataliya Sharopova,Anne Sturcke,Alejandro A. Schäffer,Nancy L. Heard-Costa,Han Chen,Han Chen,Poching Liu,Richard J. Wang,Kimberly Woodhouse,Kahraman Tanriverdi,Jane E. Freedman,Nalini Raghavachari,Josée Dupuis,Josée Dupuis,Andrew D. Johnson,Christopher J. O'Donnell,Daniel Levy,Peter J. Munson,Peter J. Munson +29 more
TL;DR: An eQTL investigation of microarray-based gene and exon expression levels in whole blood in a cohort of 5257 individuals is conducted, exceeding the single cohort size of previous studies by more than a factor of 2.5.
Journal ArticleDOI
A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease
Tianxiao Huan,Bin Zhang,Zhi Wang,Roby Joehanes,Jun Zhu,Andrew D. Johnson,Saixia Ying,Peter J. Munson,Nalini Raghavachari,Richard J. Wang,Poching Liu,Paul Courchesne,Shih-Jen Hwang,Themistocles L. Assimes,Ruth McPherson,Nilesh J. Samani,Heribert Schunkert,Qingying Meng,Christine Suver,Christopher J. O'Donnell,Jonathan M. J. Derry,Xia Yang,Daniel Levy +22 more
TL;DR: A network-driven integrative analysis not only identified CHD-related genes, but also defined network structure that sheds light on the molecular interactions of genes associated with CHD risk.
Journal ArticleDOI
Differential Impact of Systolic and Diastolic Blood Pressure Level on JNC-VI Staging
Donald M. Lloyd-Jones,Jane C. Evans,Jane C. Evans,Martin G. Larson,Martin G. Larson,Christopher J. O'Donnell,Christopher J. O'Donnell,Daniel Levy,Daniel Levy,Daniel Levy +9 more
TL;DR: In this article, the effect of disparate levels of systolic (SBP) and diastolic (DBP) levels on blood pressure staging and eligibility for therapy was evaluated, and it was shown that SBP alone correctly classified 99% of subjects; in those <60 years old, it alone classified 95%.
Journal ArticleDOI
Genome-wide association analysis identifies multiple loci related to resting heart rate
Mark Eijgelsheim,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher Newton-Cheh,Nona Sotoodehnia,Paul I.W. de Bakker,Paul I.W. de Bakker,Martina Müller,Alanna C. Morrison,Albert V. Smith,Aaron Isaacs,Serena Sanna,Marcus Dörr,Pau Navarro,Christian Fuchsberger,Ilja M. Nolte,Eco J. C. de Geus,Karol Estrada,Shih-Jen Hwang,Joshua C. Bis,Ina Maria Rückert,Alvaro Alonso,Lenore J. Launer,Jouke-Jan Hottenga,Fernando Rivadeneira,Peter A. Noseworthy,Kenneth Rice,Siegfried Perz,Dan E. Arking,Tim D. Spector,Jan A. Kors,Yurii S. Aulchenko,Kirill V. Tarasov,Georg Homuth,Sarah H. Wild,Fabio Marroni,Christian Gieger,Carmilla M.M. Licht,Ronald J. Prineas,Albert Hofman,Jerome I. Rotter,Andrew A. Hicks,Florian Ernst,Samer S. Najjar,Alan F. Wright,Annette Peters,Ervin R. Fox,Ben A. Oostra,Heyo K. Kroemer,David Couper,Henry Völzke,Harry Campbell,Thomas Meitinger,Manuela Uda,Jacqueline C.M. Witteman,Bruce M. Psaty,Bruce M. Psaty,H.-Erich Wichmann,Tamara B. Harris,Stefan Kääb,David S. Siscovick,Yalda Jamshidi,Yalda Jamshidi,André G. Uitterlinden,Aaron R. Folsom,Martin G. Larson,Martin G. Larson,James F. Wilson,Brenda W.J.H. Penninx,Harold Snieder,Harold Snieder,Peter P. Pramstaller,Cornelia M. van Duijn,Edward G. Lakatta,Stephan B. Felix,Vilmundur Gudnason,Arne Pfeufer,Susan R. Heckbert,Susan R. Heckbert,Bruno H. Stricker,Eric Boerwinkle,Christopher J. O'Donnell,Christopher J. O'Donnell +82 more
TL;DR: A meta-analysis of 15 genome-wide association studies performed to identify common genetic variants associated with heart rate found six novel associations at six loci, suggesting that some loci falling short of genome- wide significance are likely truly associated with RR interval.