C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Journal ArticleDOI
Gene Expression Signatures of Coronary Heart Disease
Roby Joehanes,Saixia Ying,Tianxiao Huan,Andrew D. Johnson,Nalini Raghavachari,Richard J. Wang,Poching Liu,Kimberly Woodhouse,Shurjo K. Sen,Kahraman Tanriverdi,Paul Courchesne,Jane E. Freedman,Christopher J. O'Donnell,Daniel Levy,Peter J. Munson +14 more
TL;DR: The findings are consistent with the hypotheses that hematopoesis is upregulated inCHD, possibly reflecting a compensatory mechanism, and that innate immune activity is disrupted in CHD or altered by its treatment.
Journal ArticleDOI
Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study.
Roberto Elosua,Roberto Elosua,Jose M. Ordovas,L. Adrienne Cupples,Caroline S. Fox,Caroline S. Fox,Joseph F. Polak,Philip A. Wolf,R. D'Agostino,Christopher J. O'Donnell,Christopher J. O'Donnell +10 more
TL;DR: The E2 allele was associated with lower carotid atherosclerosis in women, and the E4 allele wasassociated with higher internal carotids IMT in diabetic men.
Journal ArticleDOI
Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study
Sander W. van der Laan,Tove Fall,Aicha Soumare,Alexander Teumer,Sanaz Sedaghat,Jens Baumert,Delilah Zabaneh,Jessica van Setten,Ivana Išgum,Tessel E. Galesloot,Johannes Arpegård,Philippe Amouyel,Stella Trompet,Melanie Waldenberger,Marcus Dörr,Patrik K. E. Magnusson,Vilmantas Giedraitis,Anders Larsson,Andrew P. Morris,Janine F. Felix,Alanna C. Morrison,Nora Franceschini,Joshua C. Bis,Maryam Kavousi,Christopher J. O'Donnell,Fotios Drenos,Vinicius Tragante,Patricia B. Munroe,Rainer Malik,Martin Dichgans,Bradford B. Worrall,Jeanette Erdmann,Christopher P. Nelson,Nilesh J. Samani,Heribert Schunkert,Jonathan Marchini,Riyaz S. Patel,Aroon D. Hingorani,Lars Lind,Nancy L. Pedersen,Jacqueline de Graaf,Lambertus A. Kiemeney,Sebastian E. Baumeister,Oscar H. Franco,Albert Hofman,André G. Uitterlinden,Wolfgang Koenig,Christa Meisinger,Annette Peters,Barbara Thorand,J. Wouter Jukema,Bjørn Odvar Eriksen,Ingrid Toft,Tom Wilsgaard,N. Charlotte Onland-Moret,Yvonne T. van der Schouw,Stéphanie Debette,Meena Kumari,Per Svensson,Pim van der Harst,Mika Kivimäki,Brendan J. Keating,Naveed Sattar,Abbas Dehghan,Alexander P. Reiner,Erik Ingelsson,Hester M. den Ruijter,Paul I.W. de Bakker,Gerard Pasterkamp,Johan Ärnlöv,Michael V. Holmes,Folkert W. Asselbergs,Folkert W. Asselbergs +72 more
TL;DR: Mendelian randomization analyses did not support a causal role of cystatin C in the etiology of CVD, and therapeutics targeted at lowering circulating cyStatin C are unlikely to be effective in preventing CVD.
Journal ArticleDOI
Genotyping Array Design and Data Quality Control in the Million Veteran Program.
Haley Hunter-Zinck,Yunling Shi,Man Li,Bryan R Gorman,Sun-Gou Ji,Ning Sun,Teresa Webster,Andrew Liem,Paul Hsieh,Poornima Devineni,Purushotham Karnam,Xin Gong,Lakshmi Radhakrishnan,Jeanette Schmidt,Themistocles L. Assimes,Jie Huang,Cuiping Pan,Donald E. Humphries,Mary Brophy,Jennifer Moser,Sumitra Muralidhar,Grant D. Huang,Ronald M. Przygodzki,John Concato,John Michael Gaziano,Joel Gelernter,Christopher J. O'Donnell,Elizabeth R. Hauser,Hongyu Zhao,Timothy J. O'Leary,VA Million Veteran Program,VA Million Veteran Program,Philip S. Tsao,Saiju Pyarajan +33 more
TL;DR: The design and performance of the MVP 1.0 custom Axiom array is presented, which was designed and developed as a single assay to be used across the multi-ethnic MVP cohort, and it is confirmed that, with non-European individuals making up nearly 30%, MVP's substantial ancestral diversity surpasses that of other large biobanks.
Journal ArticleDOI
Circulating Uncarboxylated Matrix Gla Protein Is Associated with Vitamin K Nutritional Status, but Not Coronary Artery Calcium, in Older Adults
M. Kyla Shea,Christopher J. O'Donnell,Cees Vermeer,Elke J. Magdeleyns,Michael D. Crosier,Caren M. Gundberg,Jose M. Ordovas,Jose M. Ordovas,Stephen B. Kritchevsky,Sarah L. Booth +9 more
TL;DR: Plasma ucMGP was associated with vitamin K status biomarkers and was reduced following phylloquinone supplementation, suggesting it may be a useful marker of vitamin Kstatus in vascular tissue in healthy older adults.