C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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Controlled Trial of a Continuous Irrigation Suction Catheter vs Conventional Intermittent Suction Catheter in Clearing Bronchial Secretions from Ventilated Patients
TL;DR: It is concluded that the Irri-Cath is more effective than conventional intermittent suction catheter in clearing bronchial secretions in patients on mechanical ventilation.
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Non-invasive visualisation and volume estimation of maggot masses using computed tomography scanning.
Aidan P. Johnson,Melanie S. Archer,Lyndie Leigh-Shaw,Matthew Brown,Christopher J. O'Donnell,James F. Wallman +5 more
TL;DR: It was found that CT can be used to visualise and measure the volume of maggot masses, and a series of rules for doing so were established andEntomological features of mortuary CT scans are now routinely reported in forensic entomology casework in Victoria, Australia, as a result of this study.
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Synthetic Approaches to the New Drugs Approved During 2020.
Andrew C. Flick,Carolyn A. Leverett,Hong X. Ding,Emma L. McInturff,Sarah J. Fink,Subham Mahapatra,Daniel W. Carney,Erick A. Lindsey,Jacob C. DeForest,Scott P. France,Simon Berritt,Simone V. Bigi-Botterill,Tony Gibson,Rebecca B Watson,Yiyang Liu,Christopher J. O'Donnell +15 more
TL;DR: This Review is part of a continuing series presenting the most likely process-scale synthetic approaches to 44 new chemical entities approved for the first time anywhere in the world during 2020.
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Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin
TL;DR: Data suggest that in intact rabbit adipocytes catecholamines and forskolin are ineffective as stimulators of adenylate cyclase due to an excess of inhibitory guanine nucleotide binding proteins.
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Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program.
Yan V. Sun,Scott M. Damrauer,Qin Hui,Themistocles L. Assimes,Yuk-Lam Ho,Pradeep Natarajan,Derek Klarin,Jie Huang,Julie A. Lynch,Scott L. DuVall,Saiju Pyarajan,Jacqueline Honerlaw,J. Michael Gaziano,Kelly Cho,Daniel J. Rader,Christopher J. O'Donnell,Philip S. Tsao,Peter W.F. Wilson +17 more
TL;DR: The distribution and phenotypic effects of putatively pathogenic FH variants were heterogeneous within and across variants, and more robust evidence of genotype-phenotype associations in multiethnic populations is needed to accurately infer at-risk individuals from genetic screening.