C
Christopher J. O'Donnell
Researcher at VA Boston Healthcare System
Publications - 914
Citations - 140860
Christopher J. O'Donnell is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Framingham Heart Study & Genome-wide association study. The author has an hindex of 159, co-authored 869 publications receiving 126278 citations. Previous affiliations of Christopher J. O'Donnell include Brown University & Veterans Health Administration.
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MACE prediction using high-dimensional machine learning and mechanistic interpretation: A longitudinal cohort study in US veterans
Sayera Dhaubhadel,Beauty A. Kolade,Rachel Melo Ribeiro,Kajal Ganguly,Nicolas W. Hengartner,Tanmoy Bhattacharya,Judith D. Cohn,Kunal Agarwal,Kelly Cho,Lauren Costa,Yuk-Lam Ho,Allison Murata,G. Murata,Jason L. Vassy,Daniel Posner,John Michael Gaziano,Yi Sun,Peter W.F. Wilson,R. Madduri,Amy C. Justice,Philip S. Tsao,Christopher J. O'Donnell,Scott M. Damrauer,B. McMahon +23 more
TL;DR: In this paper , high dimensional predictive models of Major Adverse Cardiac Events (MACE), which includes heart attack (AMI), stroke, and death caused by cardiovascular disease (CVD), were built using four longitudinal cohorts of Veterans Administration patients created from VA medical records.
Journal ArticleDOI
Associations of biogeographic ancestry with hypertension traits.
Jacob M. Keaton,Jacklyn N. Hellwege,Ayush Giri,Eric S. Torstenson,Eric S. Torstenson,Csaba P. Kovesdy,Yan V. Sun,Peter W.F. Wilson,Christopher J. O'Donnell,Todd L. Edwards,Adriana M. Hung,Digna R. Velez Edwards,Million Veteran Program +12 more
TL;DR: In this paper, the authors evaluated associations of geographic genetic ancestry with hypertension and underlying blood pressure traits and showed that risk for BP traits varies significantly by genetic ancestry. But the influence of genetic ancestry is unclear.
Posted ContentDOI
Polygenic predisposition to venous thromboembolism is associated with increased COVID-19 positive testing rates
Jessica Minnier,Jennifer E. Huffman,L. Gao,Jacob Joseph,Emily S. Wan,Wen-Chih Wu,A. Suzuki,Gita A. Pathak,Renato Polimanti,Mehrdad Arjomandi,Kyong-Mi Chang,Helene Garcon,Amanda K. Verma,Yuk-Lam Ho,James B. Meigs,Kelly Cho,Robert A. Bonomo,Bryan L. Gorman,Saiju Pyarajan,Elise Gatsby,Nallakkandi Rajeevan,Karen E. Lynch,Julie Lynch,Seyedeh M. Zekavat,Pradeep Natarajan,Chloe Madison,J Zhou,Darshana Jhala,Curtis J. Donskey,John E. McGeary,Peter D. Reaven,Yi Sun,Mathew S. Freiberg,Joel Gelernter,J. M. Petersen,Adriana M. Hung,R D Huang,Ramanadham Madduri,Sharvari Dalal,Quinn S. Wells,Katherine P. Liao,Peter W.F. Wilson,Philip S. Tsao,Christopher J. O'Donnell +43 more
TL;DR: Increased genetic propensity for VTE in the MVP was associated with increased COVID-19 positive testing rates, suggesting a role of coagulation in the initial steps of CO VID-19 infection.
Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses
Daniel Levy,Steven R. DePalma,Emelia J. Benjamin,Christopher J. O'Donnell,Christopher J. O'Donnell,Helen Parise,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Ramachandran S. Vasan,Seigo Izumo,Martin G. Larson +11 more
TL;DR: This paper developed a Phenotype-Genotype Association (PGA) grid display, which can be used to visually summarize results of individual SNP associations, gene-environment associations, or haplotype associations.
Journal ArticleDOI
An image of sudden death
TL;DR: CT has been successfully integrated into the death investigative process, primarily in conjunction with autopsy but also when objection to autopsy is lodged by next of kin, together with external examination.