D
David M. Hwang
Researcher at Sunnybrook Health Sciences Centre
Publications - 184
Citations - 9146
David M. Hwang is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Lung transplantation & Lung. The author has an hindex of 48, co-authored 179 publications receiving 7241 citations. Previous affiliations of David M. Hwang include Toronto General Hospital & University Health Network.
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Journal ArticleDOI
Normothermic Ex Vivo Perfusion Prevents Lung Injury Compared to Extended Cold Preservation for Transplantation
Marcelo Cypel,M. Rubacha,Jonathan C. Yeung,S. Hirayama,K. Torbicki,M Madonik,Stefan Fischer,David M. Hwang,Andrew Pierre,Thomas K. Waddell,M. de Perrot,Mingyao Liu,Shaf Keshavjee +12 more
TL;DR: The maintenance of integrity of barrier function during EVLP translates into significant attenuation of reperfusion injury and improved graft performance after transplantation, and prevents ongoing injury associated with prolonged ischemia and accelerates lung recovery.
Journal ArticleDOI
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
Edward A. Sykes,Qin Dai,Christopher D. Sarsons,Juan Chen,Jonathan V. Rocheleau,David M. Hwang,Gang Zheng,David T. Cramb,Kristina D. Rinker,Warren C. W. Chan +9 more
TL;DR: It is discovered that changes in pathophysiology associated with tumor volume can selectively change tumor uptake of nanoparticles of varying size, and this finding presents a paradigm shift in nanomedicine away from identifying and using a universal nanoparticle design for cancer detection and treatment.
Journal ArticleDOI
The Integrated Genomic Landscape of Thymic Epithelial Tumors
Milan Radovich,Curtis R. Pickering,Ina Felau,Gavin Ha,Hailei Zhang,Heejoon Jo,Katherine A. Hoadley,Pavana Anur,Jiexin Zhang,Michael D. McLellan,Reanne Bowlby,Thomas Matthew,Ludmila Danilova,Apurva M. Hegde,Jaegil Kim,Mark D.M. Leiserson,Geetika Sethi,Charles Lu,Michael Ryan,Xiaoping Su,Andrew D. Cherniack,Gordon Robertson,Rehan Akbani,Paul T. Spellman,John N. Weinstein,D. Neil Hayes,Ben Raphael,Tara M. Lichtenberg,Kristen M. Leraas,Jean C. Zenklusen,Adrian Ally,Elizabeth L. Appelbaum,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Madhusmita Behera,Rameen Beroukhim,Mario Berrios,Giovanni Blandino,Tom Bodenheimer,Moiz S. Bootwalla,Jay Bowen,Denise Brooks,Flavio Mavignier Carcano,Rebecca Carlsen,André Lopes Carvalho,Patricia Castro,Lara Chalabreysse,Lynda Chin,Juok Cho,Gina Choe,Eric Chuah,Sudha Chudamani,Carrie Cibulskis,Leslie Cope,Matthew G. Cordes,Daniel Crain,Erin Curley,Timothy Defreitas,John A. Demchok,Frank C. Detterbeck,Noreen Dhalla,Hendrik Dienemann,W. Jeff Edenfield,Francesco Facciolo,Martin L. Ferguson,Scott Frazer,Catrina Fronick,Lucinda Fulton,Robert S. Fulton,Stacey Gabriel,Johanna Gardner,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Gad Getz,David I. Heiman,Shital Hobensack,Andrea Holbrook,Robert A. Holt,Alan P. Hoyle,Carolyn M. Hutter,Michael Ittmann,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Katayoon Kasaian,Patrick K. Kimes,Phillip H. Lai,Peter W. Laird,Michael S. Lawrence,Pei Lin,Jia Liu,Laxmi Lolla,Yiling Lu,Yussanne Ma,Dennis T. Maglinte,David Mallery,Elaine R. Mardis,Marco A. Marra,Julie S. Martin,Michael Mayo,Sam Meier,Michael Meister,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Christopher A. Miller,Gordon B. Mills,Richard A. Moore,Scott Morris,Lisle E. Mose,Thomas Muley,Andrew J. Mungall,Karen Mungall,Rashi Naresh,Yulia Newton,Michael S. Noble,Taofeek K. Owonikoko,Joel S. Parker,Joseph Paulaskis,Robert Penny,Charles M. Perou,Corinne Perrin,Todd Pihl,Amie Radenbaugh,Suresh S. Ramalingam,Nilsa C. Ramirez,Ralf J. Rieker,Jeffrey Roach,Sara Sadeghi,Gordon Saksena,Jacqueline E. Schein,Heather Schmidt,Steven E. Schumacher,Candace Shelton,Troy Shelton,Yan Shi,Juliann Shih,Gabriel Sica,Henrique César Santejo Silveira,Janae V. Simons,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Joshua M. Stuart,Qiang Sun,Angela Tam,Donghui Tan,Roy Tarnuzzer,Nina Thiessen,David Van Den Berg,Mohammad A. Vasef,Umadevi Veluvolu,Doug Voet,Vonn Walter,Yunhu Wan,Zhining Wang,Arne Warth,Cleo-Aron Weis,Daniel J. Weisenberger,Matthew D. Wilkerson,Lisa Wise,Tina Wong,Hsin-Ta Wu,Ye Wu,Liming Yang,Jiashan Zhang,Erik Zmuda,Junya Fujimoto,Cristovam Scapulatempo-Neto,Andre L. Moreira,David M. Hwang,James Huang,Mirella Marino,Robert Korst,Giuseppe Giaccone,Yesim Gökmen-Polar,Sunil Badve,Arun Rajan,Philipp Ströbel,Nicolas Girard,Ming-Sound Tsao,Alexander Marx,Anne S. Tsao,Patrick J. Loehrer +186 more
TL;DR: A molecular link between thymoma and the autoimmune disease myasthenia gravis is identified, characterized by tumoral overexpression of muscle autoantigens, and increased aneuploidy.
Journal ArticleDOI
Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis
Efrat Ofek,Masaaki Sato,Masaaki Sato,Tomohito Saito,Ute Wagnetz,Heidi C. Roberts,C. Chaparro,Thomas K. Waddell,Lianne G. Singer,Michael Hutcheon,Shaf Keshavjee,David M. Hwang,David M. Hwang +12 more
TL;DR: In this paper, the authors found that pleuroparenchymal fibroelastosis is a major histopathologic correlate of restrictive allograft syndrome, and was often found concurrently with diffuse alveolar damage.
Journal ArticleDOI
PD-L1 Testing for Lung Cancer in 2019 : Perspective From the IASLC Pathology Committee
Sylvie Lantuejoul,Ming Sound-Tsao,Wendy A Cooper,Nicolas Girard,Fred R. Hirsch,Anja C. Roden,Fernando López-Ríos,Deepali Jain,Teh Ying Chou,Noriko Motoi,Keith M. Kerr,Yasushi Yatabe,Elisabeth Brambilla,John W. Longshore,Mauro Papotti,Lynette M. Sholl,Erik Thunnissen,Natasha Rekhtman,Alain C. Borczuk,Lukas Bubendorf,Yuko Minami,Mary Beth Beasley,Johan Botling,Gang Chen,Jin Haeng Chung,Sanja Dacic,David M. Hwang,Dongmei Lin,Andre L. Moreira,Andrew G. Nicholson,Masayuki Noguchi,Giuseppe Pelosi,Claudia Poleri,William D. Travis,Akihiko Yoshida,Jillian B. Daigneault,Ignacio I. Wistuba,Mari Mino-Kenudson +37 more
TL;DR: Although PD-L1 IHC test is now deployed in the most pathology laboratories, its appropriate implementation and interpretation are critical as a predictive biomarker and can be challenging due to the multiple antibody clones and platforms or assays available and given the typically small size of samples provided.