E
Elizabeth Nickerson
Researcher at Broad Institute
Publications - 33
Citations - 22825
Elizabeth Nickerson is an academic researcher from Broad Institute. The author has contributed to research in topics: Exome & Mutation. The author has an hindex of 24, co-authored 33 publications receiving 20987 citations. Previous affiliations of Elizabeth Nickerson include University of California, Irvine & Baylor College of Medicine.
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Journal ArticleDOI
Genome sequencing in microfabricated high-density picolitre reactors
Marcel Margulies,Michael Egholm,William E. Altman,Said Attiya,Joel S. Bader,Lisa A. Bemben,Jan Berka,Michael S. Braverman,Yi-Ju Chen,Zhoutao Chen,Scott Dewell,Lei Du,J. M. Fierro,Xavier V. Gomes,Brian C. Godwin,Wen He,Scott Edward Helgesen,Chun Heen Ho,Gerard P. Irzyk,Szilveszter C. Jando,Maria L. I. Alenquer,Thomas P. Jarvie,Kshama B. Jirage,Jong-Bum Kim,James R. Knight,Janna R. Lanza,John H. Leamon,Steven Lefkowitz,Ming Lei,Jing Li,Kenton Lohman,Hong Lu,Vinod Makhijani,Keith Mcdade,Michael P. McKenna,Eugene W. Myers,Elizabeth Nickerson,John Nobile,Ramona Plant,Bernard P. Puc,Michael T. Ronan,George T. Roth,Gary J. Sarkis,Jan Fredrik Simons,John Simpson,Maithreyan Srinivasan,Karrie R. Tartaro,Alexander Tomasz,Kari A. Vogt,Greg A. Volkmer,Shally H. Wang,Yong Wang,Michael P. Weiner,Pengguang Yu,Richard F. Begley,Jonathan M. Rothberg +55 more
TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
Journal ArticleDOI
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Michael S. Lawrence,Petar Stojanov,Petar Stojanov,Paz Polak,Paz Polak,Paz Polak,Gregory V. Kryukov,Gregory V. Kryukov,Gregory V. Kryukov,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Chip Stewart,Craig H. Mermel,Craig H. Mermel,Steven A. Roberts,Adam Kiezun,Peter S. Hammerman,Peter S. Hammerman,Aaron McKenna,Aaron McKenna,Yotam Drier,Lihua Zou,Alex H. Ramos,Trevor J. Pugh,Trevor J. Pugh,Nicolas Stransky,Elena Helman,Elena Helman,Jaegil Kim,Carrie Sougnez,Lauren Ambrogio,Elizabeth Nickerson,Erica Shefler,Maria L. Cortes,Daniel Auclair,Gordon Saksena,Douglas Voet,Michael S. Noble,Daniel DiCara,Pei Lin,Lee Lichtenstein,David I. Heiman,Timothy Fennell,Marcin Imielinski,Marcin Imielinski,Bryan Hernandez,Eran Hodis,Eran Hodis,Sylvan C. Baca,Sylvan C. Baca,Austin M. Dulak,Austin M. Dulak,Jens G. Lohr,Jens G. Lohr,Dan A. Landau,Dan A. Landau,Dan A. Landau,Catherine J. Wu,Jorge Melendez-Zajgla,Alfredo Hidalgo-Miranda,Amnon Koren,Amnon Koren,Steven A. McCarroll,Steven A. McCarroll,Jaume Mora,Ryan S. Lee,Ryan S. Lee,Brian D. Crompton,Brian D. Crompton,Robert C. Onofrio,Melissa Parkin,Wendy Winckler,Kristin G. Ardlie,Stacey Gabriel,Charles W. M. Roberts,Charles W. M. Roberts,Jaclyn A. Biegel,Kimberly Stegmaier,Kimberly Stegmaier,Kimberly Stegmaier,Adam J. Bass,Adam J. Bass,Levi A. Garraway,Levi A. Garraway,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Dmitry A. Gordenin,Shamil R. Sunyaev,Shamil R. Sunyaev,Shamil R. Sunyaev,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Gad Getz +96 more
TL;DR: A fundamental problem with cancer genome studies is described: as the sample size increases, the list of putatively significant genes produced by current analytical methods burgeons into the hundreds and the list includes many implausible genes, suggesting extensive false-positive findings that overshadow true driver events.
Journal ArticleDOI
A landscape of driver mutations in melanoma
Eran Hodis,Ian R. Watson,Ian R. Watson,Gregory V. Kryukov,Gregory V. Kryukov,Gregory V. Kryukov,Stefan T. Arold,Marcin Imielinski,Jean Philippe Theurillat,Elizabeth Nickerson,Daniel Auclair,Liren Li,Liren Li,Chelsea S. Place,Daniel DiCara,Alex H. Ramos,Alex H. Ramos,Michael S. Lawrence,Kristian Cibulskis,Andrey Sivachenko,Douglas Voet,Gordon Saksena,Nicolas Stransky,Robert C. Onofrio,Wendy Winckler,Kristin G. Ardlie,Nikhil Wagle,Nikhil Wagle,Jennifer A. Wargo,Kelly Chong,Donald L. Morton,Katherine Stemke-Hale,Guo Chen,Michael S. Noble,Matthew Meyerson,John E. Ladbury,Michael A. Davies,Jeffrey E. Gershenwald,Stephan N. Wagner,Dave S.B. Hoon,Dirk Schadendorf,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Gad Getz,Levi A. Garraway,Lynda Chin +46 more
TL;DR: The spectrum of driver mutations provided unequivocal genomic evidence for a direct mutagenic role of UV light in melanoma pathogenesis, providing oncogenic insights in BRAF- and NRAS-driven melanoma as well as those without known NRAS/BRAF mutations.
Journal ArticleDOI
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Christopher E. Barbieri,Sylvan C. Baca,Sylvan C. Baca,Michael S. Lawrence,Francesca Demichelis,Francesca Demichelis,Mirjam Blattner,Jean Philippe Theurillat,Thomas A. White,Petar Stojanov,Eliezer M. Van Allen,Eliezer M. Van Allen,Nicolas Stransky,Elizabeth Nickerson,Sung Suk Chae,Gunther Boysen,Daniel Auclair,Robert C. Onofrio,Kyung Park,Naoki Kitabayashi,Theresa Y. MacDonald,Karen Sheikh,Terry Vuong,Candace Guiducci,Kristian Cibulskis,Andrey Sivachenko,Scott L. Carter,Gordon Saksena,Douglas Voet,Wasay M. Hussain,Alex H. Ramos,Alex H. Ramos,Wendy Winckler,Michelle C Redman,Kristin Ardlie,Ashutosh K. Tewari,Juan Miguel Mosquera,Niels J. Rupp,Peter J. Wild,Holger Moch,Colm Morrissey,Peter S. Nelson,Peter S. Nelson,Philip W. Kantoff,Stacey Gabriel,Todd R. Golub,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Gad Getz,Mark A. Rubin,Levi A. Garraway +51 more
TL;DR: SPOP mutations may define a new molecular subtype of prostate cancer, with mutations involving the SPOP substrate-binding cleft in 6–15% of tumors across multiple independent cohorts.
Journal ArticleDOI
The Generic Genome Browser: A Building Block for a Model Organism System Database
Lincoln Stein,Christopher J. Mungall,ShengQiang Shu,Michael Caudy,Marco Mangone,Allen Day,Elizabeth Nickerson,Jason E. Stajich,Todd W. Harris,Adrian Arva,Suzanna E. Lewis +10 more
TL;DR: The Generic Genome Browser (GBrowse) is described, a Web-based application for displaying genomic annotations and other features and easy integration with other components of a model organism system Web site.