Fangping Cai

TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.

TL;DR: TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.

TL;DR: The B cell response in a bnAb-producing individual is studied and two B cell lineages cooperated to induce the development of bnAbs, a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced B cell lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive.

TL;DR: It is explained how CD8+ T cells can exert significant and sustained HIV-1 pressure even when escape is very slow and that within an individual, the impacts of other T cell factors on HIV- 1 escape should be considered in the context of immunodominance.

TL;DR: In this paper, SARS-CoV-2 neutralizing antibodies (NAbs) were isolated against the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the SARS CoV2 spike.