F
Fangping Cai
Researcher at Duke University
Publications - 31
Citations - 2910
Fangping Cai is an academic researcher from Duke University. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 18, co-authored 31 publications receiving 2345 citations. Previous affiliations of Fangping Cai include Durham University.
Papers
More filters
Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
Journal ArticleDOI
Phenotypic properties of transmitted founder HIV-1
Nicholas F. Parrish,Feng Gao,Hui Li,Elena E. Giorgi,Hannah J. Barbian,Erica H. Parrish,Lara Zajic,Shilpa S. Iyer,Julie M. Decker,Amit Kumar,Bhavna Hora,Anna Berg,Fangping Cai,Jennifer Hopper,Thomas N. Denny,Haitao Ding,Christina Ochsenbauer,John C. Kappes,Rachel P. Galimidi,Anthony P. West,Pamela J. Bjorkman,Craig B. Wilen,Robert W. Doms,Robert W. Doms,Meagan O’Brien,Nina Bhardwaj,Persephone Borrow,Barton F. Haynes,Mark Muldoon,James Theiler,Bette T. Korber,George M. Shaw,Beatrice H. Hahn +32 more
TL;DR: TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.
Journal ArticleDOI
Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies
Feng Gao,Mattia Bonsignori,Hua-Xin Liao,Amit Kumar,Shi Mao Xia,Xiaozhi Lu,Fangping Cai,Kwan Ki Hwang,Hongshuo Song,Tongqing Zhou,Rebecca M. Lynch,S. Munir Alam,M. Anthony Moody,Guido Ferrari,Mark Berrong,Garnett Kelsoe,George M. Shaw,Beatrice H. Hahn,David C. Montefiori,Gift Kamanga,Myron S. Cohen,Peter T. Hraber,Peter D. Kwong,Bette T. Korber,John R. Mascola,Thomas B. Kepler,Barton F. Haynes +26 more
TL;DR: The B cell response in a bnAb-producing individual is studied and two B cell lineages cooperated to induce the development of bnAbs, a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced B cell lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive.
Journal ArticleDOI
Vertical T cell immunodominance and epitope entropy determine HIV-1 escape
Michael K. P. Liu,Natalie Hawkins,Adam J. Ritchie,Vitaly V. Ganusov,Victoria E. Whale,Simon Brackenridge,Hui Li,Jeffrey W. Pavlicek,Fangping Cai,Melissa Rose-Abrahams,Florette K. Treurnicht,Peter T. Hraber,Catherine Riou,Clive M. Gray,Guido Ferrari,Rachel Tanner,Li Hua Ping,Jeffrey A. Anderson,Ronald Swanstrom,Myron S. Cohen,Salim S. Abdool Karim,Barton F. Haynes,Persephone Borrow,Alan S. Perelson,Alan S. Perelson,George M. Shaw,Beatrice H. Hahn,Carolyn Williamson,Bette T. Korber,Bette T. Korber,Feng Gao,Steve Self,Andrew J. McMichael,Nilu Goonetilleke +33 more
TL;DR: It is explained how CD8+ T cells can exert significant and sustained HIV-1 pressure even when escape is very slow and that within an individual, the impacts of other T cell factors on HIV- 1 escape should be considered in the context of immunodominance.
Journal ArticleDOI
In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.
Dapeng Li,Robert J. Edwards,Kartik Manne,David R. Martinez,Alexandra Schäfer,S. Munir Alam,Kevin Wiehe,Xiaozhi Lu,Robert Parks,Laura L. Sutherland,Thomas H. Oguin,Charlene McDanal,Lautaro G. Perez,Katayoun Mansouri,Sophie M. C. Gobeil,Katarzyna Janowska,Victoria Stalls,Megan Kopp,Fangping Cai,Esther J. Lee,Andrew Foulger,Giovanna Hernandez,Aja Sanzone,Kedamawit Tilahun,Chuancang Jiang,Longping V. Tse,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Kenneth D. Cronin,Victoria Gee-Lai,Margaret Deyton,Maggie Barr,Tarra Von Holle,Andrew N. Macintyre,Erica Stover,Jared Feldman,Blake M. Hauser,Timothy M. Caradonna,Trevor Scobey,Wes Rountree,Yunfei Wang,M. Anthony Moody,Derek W. Cain,C. Todd DeMarco,Thomas N. Denny,Christopher W. Woods,Elizabeth Petzold,Aaron G. Schmidt,Aaron G. Schmidt,I-Ting Teng,Tongqing Zhou,Peter D. Kwong,Peter D. Kwong,John R. Mascola,Barney S. Graham,Ian N. Moore,Robert A. Seder,Hanne Leth Andersen,Mark G. Lewis,David C. Montefiori,Gregory D. Sempowski,Ralph S. Baric,Priyamvada Acharya,Barton F. Haynes,Kevin O. Saunders +65 more
TL;DR: In this paper, SARS-CoV-2 neutralizing antibodies (NAbs) were isolated against the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the SARS CoV2 spike.