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Francisco Sanchez-Vega
Researcher at Memorial Sloan Kettering Cancer Center
Publications - Â 115
Citations - Â 20975
Francisco Sanchez-Vega is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 36, co-authored 84 publications receiving 13474 citations. Previous affiliations of Francisco Sanchez-Vega include Washington University in St. Louis & National Institutes of Health.
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Journal ArticleDOI
The Molecular Taxonomy of Primary Prostate Cancer
Adam Abeshouse,Jaeil Ahn,Rehan Akbani,Adrian Ally,Samirkumar B. Amin,Christopher D. Andry,Matti Annala,Armen Aprikian,Joshua Armenia,Arshi Arora,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Christopher E. Barbieri,Thomas L. Bauer,Christopher C. Benz,Alain Bergeron,Rameen Beroukhim,Mario Berrios,Adrian Bivol,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Rodolfo Borges Dos Reis,Paul C. Boutros,Jay Bowen,Reanne Bowlby,Jeff Boyd,Robert K. Bradley,Anne Breggia,Fadi Brimo,Christopher A. Bristow,Denise Brooks,Bradley M. Broom,Alan H. Bryce,Glenn Bubley,Eric J. Burks,Yaron S.N. Butterfield,Michael Button,David Canes,Carlos Gilberto Carlotti,Rebecca Carlsen,Michel Carmel,Peter R. Carroll,Scott L. Carter,Richard Cartun,Brett S. Carver,June M. Chan,Matthew T. Chang,Yu Chen,Andrew D. Cherniack,Simone Chevalier,Lynda Chin,Juok Cho,Andy Chu,Eric Chuah,Sudha Chudamani,Kristian Cibulskis,Giovanni Ciriello,Amanda Clarke,Matthew R. Cooperberg,Niall M. Corcoran,Anthony J. Costello,Janet E. Cowan,Daniel Crain,Erin Curley,Kerstin David,John A. Demchok,Francesca Demichelis,Noreen Dhalla,Rajiv Dhir,Alexandre Doueik,Bettina F. Drake,Heidi Dvinge,Natalya Dyakova,Ina Felau,Martin L. Ferguson,Scott Frazer,Stephen J. Freedland,Yao Fu,Stacey Gabriel,Jianjiong Gao,Johanna Gardner,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Mark Gerstein,Gad Getz,Andrew K. Godwin,Anuradha Gopalan,Markus Graefen,Kiley Graim,Thomas Gribbin,Ranabir Guin,Manaswi Gupta,Angela Hadjipanayis,Syed Haider,Lucie Hamel,D. Neil Hayes,David I. Heiman,Julian M. Hess,Katherine A. Hoadley,Andrea Holbrook,Robert A. Holt,Antonia H. Holway,Christopher M. Hovens,Alan P. Hoyle,Mei Huang,Carolyn M. Hutter,Michael Ittmann,Lisa Iype,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Hartmut Juhl,Andre Kahles,Christopher J. Kane,Katayoon Kasaian,Michael Kerger,Ekta Khurana,Jaegil Kim,Robert J. Klein,Raju Kucherlapati,Louis Lacombe,Marc Ladanyi,Phillip H. Lai,Peter W. Laird,Eric S. Lander,Mathieu Latour,Michael S. Lawrence,Kevin Lau,Tucker W. LeBien,Darlene Lee,Semin Lee,Kjong-Van Lehmann,Kristen M. Leraas,Ignaty Leshchiner,Robert Leung,John A. Libertino,Tara M. Lichtenberg,Pei Lin,W. Marston Linehan,Shiyun Ling,Scott M. Lippman,Jia Liu,Wen-Bin Liu,Lucas Lochovsky,Massimo Loda,Christopher J. Logothetis,Laxmi Lolla,Teri A. Longacre,Yiling Lu,Jianhua Luo,Yussanne Ma,Harshad S. Mahadeshwar,David Mallery,Armaz Mariamidze,Marco A. Marra,Michael Mayo,Shannon J. McCall,Ginette McKercher,Shaowu Meng,Anne Marie Mes-Masson,Maria J. Merino,Matthew Meyerson,Piotr A. Mieczkowski,Gordon B. Mills,Kenna R. Mills Shaw,Sarah Minner,Alireza Moinzadeh,Richard A. Moore,Scott Morris,Carl Morrison,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Jerome Myers,Rashi Naresh,Joel Nelson,Mark Nelson,Peter S. Nelson,Yulia Newton,Michael S. Noble,Houtan Noushmehr,Matti Nykter,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Joel S. Parker,Joseph Paulauskis,Robert Penny,Charles M. Perou,Alain PichĂ©,Todd Pihl,Peter A. Pinto,Davide Prandi,Alexei Protopopov,Nilsa C. Ramirez,Arvind Rao,W. Kimryn Rathmell,Gunnar Rätsch,Xiaojia Ren,Victor E. Reuter,Sheila Reynolds,Suhn K. Rhie,Kimberly Rieger-Christ,Jeffrey Roach,A. Gordon Robertson,Brian D. Robinson,Mark A. Rubin,Fred Saad,Sara Sadeghi,Gordon Saksena,Charles Saller,Andrew Salner,Francisco Sanchez-Vega,Chris Sander,George E. Sandusky,Guido Sauter,Andrea Sboner,Peter T. Scardino,Eleonora Scarlata,Jacqueline E. Schein,Thorsten Schlomm,Laura S. Schmidt,Nikolaus Schultz,Steven E. Schumacher,Jonathan G. Seidman,Luciano Neder,Sahil Seth,Alexis Sharp,Candace Shelton,Troy Shelton,Hui Shen,Ronglai Shen,Mark E. Sherman,Margi Sheth,Yan Shi,Juliann Shih,Ilya Shmulevich,Jeffry Simko,Ronald Simon,Janae V. Simons,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Andrea Sorcini,Carrie Sougnez,Serghei Stepa,Chip Stewart,John A. Stewart,Joshua M. Stuart,Travis Sullivan,Charlie Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Katherine Tarvin,Barry S. Taylor,Patrick Teebagy,Imelda Tenggara,Bernard TĂªtu,Ashutosh Tewari,Nina Thiessen,Timothy C. Thompson,Leigh B. Thorne,Daniela P. Tirapelli,Scott A. Tomlins,Felipe Amstalden Trevisan,Patricia Troncoso,Lawrence D. True,Maria Christina Tsourlakis,Svitlana Tyekucheva,Eliezer M. Van Allen,David Van Den Berg,Umadevi Veluvolu,Roeland Verhaak,Cathy D. Vocke,Doug Voet,Yunhu Wan,Qingguo Wang,Wenyi Wang,Zhining Wang,Nils Weinhold,John N. Weinstein,Daniel J. Weisenberger,Matthew D. Wilkerson,Lisa Wise,John S. Witte,Chia Chin Wu,Junyuan Wu,Ye Wu,Andrew Wei Xu,Shalini S. Yadav,Liming Yang,Lixing Yang,Christina Yau,Huihui Ye,Peggy Yena,Thomas Zeng,Jean C. Zenklusen,Hailei Zhang,Jianhua Zhang,Jiashan Zhang,Wei Zhang,Yi Zhong,Kelsey Zhu,Erik Zmuda +311 more
TL;DR: The Cancer Genome Atlas (TCGA) has been used for a comprehensive molecular analysis of primary prostate carcinomas as discussed by the authors, revealing substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course.
Journal ArticleDOI
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega,Marco Mina,Joshua Armenia,Walid K. Chatila,Augustin Luna,Konnor La,Sofia Dimitriadoy,David L. Liu,Havish S. Kantheti,Sadegh Saghafinia,Debyani Chakravarty,Foysal Daian,Qingsong Gao,Matthew H. Bailey,Wen-Wei Liang,Steven M. Foltz,Ilya Shmulevich,Li Ding,Zachary J. Heins,Angelica Ochoa,Benjamin Gross,Jianjiong Gao,Hongxin Zhang,Ritika Kundra,Cyriac Kandoth,Istemi Bahceci,Leonard Dervishi,Ugur Dogrusoz,Wanding Zhou,Hui Shen,Peter W. Laird,Gregory P. Way,Casey S. Greene,Han Liang,Yonghong Xiao,Chen Wang,Antonio Iavarone,Alice H. Berger,Trever G. Bivona,Alexander J. Lazar,Gary D. Hammer,Thomas J. Giordano,Lawrence N. Kwong,Grant A. McArthur,Chenfei Huang,Aaron D. Tward,Mitchell J. Frederick,Frank McCormick,Matthew Meyerson,Eliezer M. Van Allen,Andrew D. Cherniack,Giovanni Ciriello,Chris Sander,Nikolaus Schultz +53 more
TL;DR: This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity.
The Molecular Taxonomy of Primary Prostate Cancer
Adam Abeshouse,Jaeil Ahn,Rehan Akbani,Adrian Ally,Samirkumar B. Amin,Chris Andry,Matti Annala,Armen Aprikian,Joshua Armenia,Arshi Arora,J. Todd Auman,Miruna Balasundaram,Saianand Balu,Christopher E. Barbieri,Thomas L. Bauer,Christopher C. Benz,Alain Bergeron,Rameen Beroukhim,Mario Berrios,Adrian Bivol,Tom Bodenheimer,Lori Boice,Moiz S. Bootwalla,Rodolfo Borges dos Reis,Paul C. Boutros,Jay Bowen,Reanne Bowlby,Jeff Boyd,Anne Breggia,Fadi Brimo,Denise Brooks,Bradley M. Broom,Alan H. Bryce,Glenn J. Bubley,Eric J. Burks,Yaron S.N. Butterfield,Michael Button,David Canes,Carlos Gilberto Carlotti,Rebecca Carlsen,Peter R. Carroll,Richard Cartun,Brett S. Carver,June M. Chan,Matthew T. Chang,Yu Chen,Anthony J. Costello,Andrew D. Cherniack,Simone Chevalier,Juok Cho,Andy Chu,Eric Chuah,Sudha Chudamani,Giovanni Ciriello,Amanda Clarke,Matthew R. Cooperberg,Niall M. Corcoran,Janet E. Cowan,Daniel Crain,Erin Curley,Kerstin David,John A. Demchok,Francesca Demichelis,Noreen Dhalla,Rajiv Dhir,Alexandre Doueik,Bettina F. Drake,Heidi Dvinge,Natalya Dyakova,Ina Felau,Martin L. Ferguson,Scott Frazer,Stephen J. Freedland,Yao Fu,Christopher A. Bristow,Jianjiong Gao,Johanna Gardner,Julie M. Gastier-Foster,Nils Gehlenborg,Mark Gerken,Mark Gerstein,Andrew K. Godwin,Anuradha Gopalan,Markus Graefen,Kiley Graim,Thomas Gribbin,Ranabir Guin,Manaswi Gupta,Angela Hadjipanayis,Syed Haider,Lucie Hamel,D. Neil Hayes,Julian M. Hess,Katherine A. Hoadley,Andrea Holbrook,Robert A. Holt,Antonia H. Holway,Christopher M. Hovens,Alan P. Hoyle,Mei Huang,Carolyn M. Hutter,Michael Ittmann,Lisa Iype,Stuart R. Jefferys,Corbin D. Jones,Steven J.M. Jones,Hartmut Juhl,AndrĂ© Kahles,Christopher J. Kane,Katayoon Kasaian,Michael Kerger,Ekta Khurana,Jaegil Kim,Robert J. Klein,Raju Kucherlapati,Louis Lacombe,Marc Ladanyi,Phillip H. Lai,Peter W. Laird,Mathieu Latour,Michael S. Lawrence,Kevin Lau,Tucker W. LeBien,Darlene Lee,Semin Lee,Kjong-Van Lehmann,Kristen M. Leraas,Ignaty Leshchiner,Robert Leung,John A. Libertino,Tara M. Lichtenberg,W. Marston Linehan,Shiyun Ling,Scott M. Lippman,Jia Liu,Wen-Bin Liu,Lucas Lochovsky,Christopher J. Logothetis,Laxmi Lolla,Teri A. Longacre,Yiling Lu,Jianhua Luo,Yussanne Ma,Harshad S. Mahadeshwar,David Mallery,Armaz Mariamidze,Marco A. Marra,Michael Mayo,Shannon J. McCall,Ginette McKercher,Shaowu Meng,Anne-Marie Mes-Masson,Maria J. Merino,Piotr A. Mieczkowski,Gordon B. Mills,Kenna R. Mills Shaw,Sarah Minner,Alireza Moinzadeh,Richard A. Moore,Scott Morris,Carl Morrison,Lisle E. Mose,Andrew J. Mungall,Bradley A. Murray,Jerome Myers,Rashi Naresh,Joel Nelson,Mark Nelson,Peter S. Nelson,Yulia Newton,Michael S. Noble,Houtan Noushmehr,Matti Nykter,Angeliki Pantazi,Michael Parfenov,Joel S. Parker,Joseph Paulauskis,Robert Penny,Charles M. Perou,Alain PichĂ©,Todd Pihl,Peter A. Pinto,Davide Prandi,Alexei Protopopov,Nilsa C. Ramirez,Arvind Rao,W. Kimryn Rathmell,Gunnar Rätsch,Xiaojia Ren,Victor E. Reuter,Sheila Reynolds,Suhn K. Rhie,Kimberly M. Rieger-Christ,Jeffrey Roach,A. Gordon Robertson,Brian D. Robinson,Mark A. Rubin,Fred Saad,Sara Sadeghi,Gordon Saksena,Charles Saller,Andrew Salner,Francisco Sanchez-Vega,Chris Sander,George E. Sandusky,Guido Sauter,Andrea Sboner,Peter T. Scardino,Eleonora Scarlata,Jacqueline E. Schein,Thorsten Schlomm,Laura S. Schmidt,Nikolaus Schultz,Steven E. Schumacher,Luciano Neder,Sahil Seth,Alexis Sharp,Candace Shelton,Troy Shelton,Hui Shen,Ronglai Shen,Mark E. Sherman,Margi Sheth,Yan Shi,Juliann Shih,Ilya Shmulevich,Jeffry P. Simko,Ronald Simon,Janae V. Simons,Payal Sipahimalani,Tara Skelly,Heidi J. Sofia,Matthew G. Soloway,Xingzhi Song,Andrea Sorcini,Serghei Stepa,Chip Stewart,John Stewart,Joshua M. Stuart,Travis Sullivan,Charlie Sun,Huandong Sun,Angela Tam,Donghui Tan,Jiabin Tang,Roy Tarnuzzer,Katherine Tarvin,Barry S. Taylor,Patrick Teebagy,Imelda Tenggara,Bernard TĂªtu,Ashutosh Tewari,Nina Thiessen,Timothy C. Thompson,Leigh B. Thorne,Daniela Pretti da Cunha Tirapelli,Scott A. Tomlins,Felipe Amstalden Trevisan,Patricia Troncoso,Lawrence D. True,Maria Christina Tsourlakis,Svitlana Tyekucheva,Eliezer M. Van Allen,David Van Den Berg,Umadevi Veluvolu,Cathy D. Vocke,Yunhu Wan,Qingguo Wang,Wenyi Wang,Zhining Wang,Nils Weinhold,John N. Weinstein,Daniel J. Weisenberger,Matthew D. Wilkerson,Lisa Wise,John S. Witte,Chia Chin Wu,Junyuan Wu,Ye Wu,Andrew Wei Xu,Shalini S. Yadav,Liming Yang,Lixing Yang,Christina Yau,Huihui Ye,Peggy Yena,Thomas Zeng,Jean C. Zenklusen,Hailei Zhang,Jiashan Zhang,Wei Zhang,Yi Zhong,Kelsey Zhu,Erik Zmuda,Robert K. Bradley,Michelle Carmell,Scott L. Carter,Lynda Chin,Kristian Cibulskis,Gad Getz,David I. Heiman,Eric S. Lander,Pei Lin,Massimo Loda,Matthew Meyerson,Peter J. Park,Jonathan G. Seidman,Carrie Sougnez,Roel G.W. Verhaak,Douglas Voet +309 more
TL;DR: A comprehensive molecular analysis of 333 primary prostate carcinomas revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).
Journal ArticleDOI
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
A. Gordon Robertson,Jaegil Kim,Hikmat Al-Ahmadie,Joaquim Bellmunt,Guangwu Guo,Andrew D. Cherniack,Toshinori Hinoue,Peter W. Laird,Katherine A. Hoadley,Rehan Akbani,Mauro A. A. Castro,Ewan A. Gibb,Rupa S. Kanchi,Dmitry A. Gordenin,Sachet A. Shukla,Francisco Sanchez-Vega,Donna E. Hansel,Bogdan Czerniak,Victor E. Reuter,Xiaoping Su,Benilton S. Carvalho,Vinicius S Chagas,Karen Mungall,Sara Sadeghi,Chandra Sekhar Pedamallu,Yiling Lu,Leszek J. Klimczak,Jiexin Zhang,Caleb Choo,Akinyemi I. Ojesina,Susan Bullman,Kristen M. Leraas,Tara M. Lichtenberg,Catherine J. Wu,N. Schultz,Gad Getz,Matthew Meyerson,Gordon B. Mills,David J. McConkey,Monique Albert,Iakovina Alexopoulou,Adrian Ally,Tatjana Antic,Manju Aron,Miruna Balasundaram,John M. S. Bartlett,Stephen B. Baylin,Allison Beaver,Inanc Birol,Lori Boice,Moiz S. Bootwalla,Jay Bowen,Reanne Bowlby,Denise Brooks,Bradley M. Broom,Wiam Bshara,Eric J. Burks,Flavio Mavignier Carcano,Rebecca Carlsen,André Lopes Carvalho,Eric P. Castle,Patricia Castro,James W.F. Catto,David Chesla,Eric Chuah,Sudha Chudamani,Victoria K. Cortessis,Sandra Cottingham,Daniel Crain,Erin Curley,Siamak Daneshmand,John A. Demchok,Noreen Dhalla,Hooman Djaladat,John Eckman,Sophie C. Egea,Jay Engel,Ina Felau,Martin L. Ferguson,Johanna Gardner,Julie M. Gastier-Foster,Mark Gerken,Carmen Gomez-Fernandez,Jodi Harr,Arndt Hartmann,Lynn M. Herbert,Thai H. Ho,Robert A. Holt,Carolyn M. Hutter,Steven J.M. Jones,Merce Jorda,Richard J. Kahnoski,Katayoon Kasaian,David J. Kwiatkowski,Phillip H. Lai,Brian R. Lane,Seth P. Lerner,Jia Liu,Laxmi Lolla,Yair Lotan,Fabiano R. Lucchesi,Yussanne Ma,Roberto Dias Machado,Dennis T. Maglinte,David Mallery,Marco A. Marra,Sue E. Martin,Michael Mayo,Anoop Meraney,Alireza Moinzadeh,Richard A. Moore,Edna M. Mora Pinero,Scott Morris,Carl Morrison,Andrew J. Mungall,Jerome Myers,Rashi Naresh,Peter H. O'Donnell,Dipen J. Parekh,Jeremy Parfitt,Joseph Paulauskis,Robert Penny,Todd Pihl,Sima P. Porten,Mario Quintero-Aguilo,Nilsa C. Ramirez,W. Kimryn Rathmell,Kimberly M. Rieger-Christ,Charles Saller,Andrew Salner,George E. Sandusky,Cristovam Scapulatempo-Neto,Jacqueline E. Schein,Anne Schuckman,Candace Shelton,Troy Shelton,Jeff Simko,Parminder Singh,Payal Sipahimalani,Norm D. Smith,Heidi J. Sofia,Andrea Sorcini,Melissa L. Stanton,Gary D. Steinberg,Robert Stoehr,Travis Sullivan,Qiang Sun,Angela Tam,Roy Tarnuzzer,Katherine Tarvin,Helge Taubert,Nina Thiessen,Leigh B. Thorne,Kane Tse,Kelinda Tucker,David Van Den Berg,Kim E.M. van Kessel,Sven Wach,Yunhu Wan,Zhining Wang,John N. Weinstein,Daniel J. Weisenberger,Lisa Wise,Tina Wong,Ye Wu,Liming Yang,Leigh Anne Zach,Jean C. Zenklusen,Jiashan Zhang,Erik Zmuda,Ellen C. Zwarthoff +170 more
TL;DR: An analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms identified 5 expression subtypes that may stratify response to different treatments and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked small cell or neuroendocrine histology.
Journal ArticleDOI
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Adrian Ally,Miruna Balasundaram,Rebecca Carlsen,Eric Chuah,Amanda Clarke,Noreen Dhalla,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Yussanne Ma,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Dorothy Cheung,Tina Wong,Denise Brooks,A. Gordon Robertson,Reanne Bowlby,Karen Mungall,Sara Sadeghi,Liu Xi,Kyle R. Covington,Eve Shinbrot,David A. Wheeler,Richard A. Gibbs,Lawrence A. Donehower,Linghua Wang,Jay Bowen,Julie M. Gastier-Foster,Mark Gerken,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Lisa Wise,Erik Zmuda,Stacey Gabriel,Matthew Meyerson,Carrie Cibulskis,Bradley A. Murray,Juliann Shih,Rameen Beroukhim,Andrew D. Cherniack,Steven E. Schumacher,Gordon Saksena,Chandra Sekhar Pedamallu,Lynda Chin,Gad Getz,Michael S. Noble,Hailei Zhang,David I. Heiman,Juok Cho,Nils Gehlenborg,Douglas Voet,Pei Lin,Scott Frazer,Timothy Defreitas,Sam Meier,Michael S. Lawrence,Jaegil Kim,Chad J. Creighton,Donna M. Muzny,Harshavardhan Doddapaneni,Jianhong Hu,Min Wang,Donna Morton,Viktoriya Korchina,Yi Han,Huyen Dinh,Lora Lewis,Michelle Bellair,Xiuping Liu,Jireh Santibanez,Robert Glenn,Sandra Lee,Walker Hale,Joel S. Parker,Matthew D. Wilkerson,D. Neil Hayes,Sheila Reynolds,Ilya Shmulevich,Wei Zhang,Yuexin Liu,Lisa Iype,Hala Makhlouf,Michael Torbenson,Sanjay Kakar,Matthew M. Yeh,Dhanpat Jain,David E. Kleiner,Renumathy Dhanasekaran,Hashem B. El-Serag,Sun Young Yim,John N. Weinstein,Lopa Mishra,Jianping Zhang,Rehan Akbani,Shiyun Ling,Zhenlin Ju,Xiaoping Su,Apurva M. Hegde,Gordon B. Mills,Yiling Lu,Jian Chen,Ju Seog Lee,Bo Hwa Sohn,Jae-Jun Shim,Pan Tong,Hiroyuki Aburatani,Shogo Yamamoto,Kenji Tatsuno,Wei Li,Zheng Xia,Nicolas Stransky,Eric Seiser,Federico Innocenti,Jianjiong Gao,Ritika Kundra,Hongxin Zhang,Zachary J. Heins,Angelica Ochoa,Chris Sander,Marc Ladanyi,Ronglai Shen,Arshi Arora,Francisco Sanchez-Vega,Nikolaus Schultz,Katayoon Kasaian,Amie Radenbaugh,Karl-Dimiter Bissig,David D. Moore,Yasushi Totoki,Hiromi Nakamura,Tatsuhiro Shibata,Christina Yau,Kiley Graim,Josh Stuart,David Haussler,Betty L. Slagle,Akinyemi I. Ojesina,Panagiotis Katsonis,Amanda Koire,Olivier Lichtarge,Teng-Kuei Hsu,Martin L. Ferguson,John A. Demchok,Ina Felau,Margi Sheth,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Jiashan Zhang,Carolyn M. Hutter,Heidi J. Sofia,Roel G.W. Verhaak,Siyuan Zheng,Frederick Lang,Sudha Chudamani,Jia Liu,Laxmi Lolla,Ye Wu,Rashi Naresh,Todd Pihl,Charlie Sun,Yunhu Wan,Christopher C. Benz,Amy H. Perou,Leigh B. Thorne,Lori Boice,Mei Huang,W. Kimryn Rathmell,Houtan Noushmehr,Fabiano Pinto Saggioro,Daniela Pretti da Cunha Tirapelli,Carlos Gilberto Carlotti Junior,Enio David Mente,Orlando de Castro Silva,Felipe Amstalden Trevisan,Koo Jeong Kang,Keun Soo Ahn,Nasra H. Giama,Catherine D. Moser,Thomas J. Giordano,Michelle Vinco,Theodore H. Welling,Daniel Crain,Erin Curley,Johanna Gardner,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,Troy Shelton,Robin Kate Kelley,Joong-Won Park,Vishal S. Chandan,Lewis R. Roberts,Oliver F. Bathe,Curt H. Hagedorn,J. Todd Auman,Daniel R. O'Brien,Jean-Pierre A. Kocher,Corbin D. Jones,Piotr A. Mieczkowski,Charles M. Perou,Tara Skelly,Donghui Tan,Umadevi Veluvolu,Saianand Balu,Tom Bodenheimer,Alan P. Hoyle,Stuart R. Jefferys,Shaowu Meng,Lisle E. Mose,Yan Shi,Janae V. Simons,Matthew G. Soloway,Jeffrey Roach,Katherine A. Hoadley,Stephen B. Baylin,Hui Shen,Toshinori Hinoue,Moiz S. Bootwalla,David Van Den Berg,Daniel J. Weisenberger,Phillip H. Lai,Andrea Holbrook,Mario Berrios,Peter W. Laird +235 more
TL;DR: Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts and development of a p53 target gene expression signature correlating with poor survival was enabled.