C
Carl A. Melbourne
Researcher at University of Leicester
Publications - 33
Citations - 902
Carl A. Melbourne is an academic researcher from University of Leicester. The author has contributed to research in topics: Medicine & Health care. The author has an hindex of 8, co-authored 23 publications receiving 384 citations. Previous affiliations of Carl A. Melbourne include National Institute for Health Research.
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Journal ArticleDOI
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nick Shrine,Anna L. Guyatt,A. Mesut Erzurumluoglu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Brian D. Hobbs,Carl A. Melbourne,Chiara Batini,Katherine A. Fawcett,Kijoung Song,Phuwanat Sakornsakolpat,Phuwanat Sakornsakolpat,Xingnan Li,Ruth Boxall,Nicola F. Reeve,Ma'en Obeidat,Jing Hua Zhao,Matthias Wielscher,Stefan Weiss,Katherine A. Kentistou,James P. Cook,Benjamin B. Sun,Jian Zhou,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah E. Harris,Jonathan Marten,Stefan Enroth,Shona M. Kerr,Ida Surakka,Vitart,Terho Lehtimäki,Richard J. Allen,Per Bakke,Terri H. Beaty,Eugene R. Bleecker,Yohan Bossé,Corry-Anke Brandsma,Zhengming Chen,James D. Crapo,John Danesh,Dawn L. DeMeo,Frank Dudbridge,Ralf Ewert,Christian Gieger,Amund Gulsvik,Anna Hansell,Ke Hao,Joshua D. Hoffman,John E. Hokanson,Georg Homuth,Peter K. Joshi,Philippe Joubert,Claudia Langenberg,Liming Li,Kuang Lin,Lars Lind,Nicholas Locantore,Jian'an Luan,Anubha Mahajan,Joseph C. Maranville,Alison Catherine Murray,David C. Nickle,Richard Packer,Margaret M. Parker,Megan L. Paynton,David J. Porteous,Dmitry Prokopenko,Dandi Qiao,Rajesh Rawal,Heiko Runz,Ian Sayers,Don D. Sin,Blair H. Smith,María Soler Artigas,David Sparrow,Ruth Tal-Singer,Timmers Prhj,van den Berge M,John C. Whittaker,Prescott G. Woodruff,Laura M Yerges Armstrong,Olga G. Troyanskaya,Olli T. Raitakari,Mika Kähönen,Ozren Polasek,Ozren Polasek,Ulf Gyllensten,Igor Rudan,Ian J. Deary,Nicole Probst-Hensch,Nicole Probst-Hensch,Holger Schulz,Alan James,Alan James,James F. Wilson,Beate Stubbe,Eleftheria Zeggini,Marjo-Riitta Järvelin,Nicholas J. Wareham,Edwin K. Silverman,Caroline Hayward,Andrew P. Morris,Andrew P. Morris,Adam S. Butterworth,Robert A. Scott,Robin G Walters,Deborah A. Meyers,Michael H. Cho,David P. Strachan,Ian P. Hall,Tobin,Louise V. Wain,Louise V. Wain +115 more
TL;DR: In this paper, a genome-wide association study in 400,102 individuals of European ancestry was conducted to define 279 lung function signals, 139 of which are new and the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups.
Journal Article
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (vol 51, pg 481, 2019)
Nick Shrine,Anna L. Guyatt,A. Mesut Erzurumluoglu,Victoria E. Jackson,Brian D. Hobbs,Carl A. Melbourne,Chiara Batini,Katherine A. Fawcett,Kijoung Song,Phuwanat Sakornsakolpat,Xingnan Li,Ruth Boxall,Nicola F. Reeve,Ma'en Obeidat,Jing Hua Zhao,Matthias Wielscher,Stefan Weiss,Katherine A. Kentistou,James P. Cook,Benjamin B. Sun,Jian Zhou,Jennie Hui,Stefan Karrasch,Medea Imboden,Sarah E. Harris,Jonathan Marten,Stefan Enroth,Shona M. Kerr,Ida Surakka,Veronique Vitart,Terho Lehtimäki,Richard J. Allen,Per Bakke,Terri H. Beaty,Eugene R. Bleecker,Yohan Bossé,Corry-Anke Brandsma,Zhengming Chen,James D. Crapo,John Danesh,Dawn L. DeMeo,Frank Dudbridge,Ralf Ewert,Christian Gieger,Amund Gulsvik,Anna Hansell,Ke Hao,Joshua D. Hoffman,Xuan Li,Maarten van den Berge +49 more
TL;DR: A genome-wide association study in more than 400,000 individuals identifies 139 new signals for lung function that can predict chronic obstructive pulmonary disease in independent, transancestral cohorts and has potential to improve future preventive and therapeutic strategies for COPD.
Journal ArticleDOI
Ethnic differences in SARS-CoV-2 vaccine hesitancy in United Kingdom healthcare workers: Results from the UK-REACH prospective nationwide cohort study.
Katherine Woolf,I Chris McManus,Christopher A Martin,Christopher A Martin,Laura B Nellums,Anna L. Guyatt,Carl A. Melbourne,Luke Bryant,Mayuri Gogoi,Fatimah Wobi,Amani Al-Oraibi,Osama Hassan,Amit Gupta,Catherine John,Martin D. Tobin,Sue Carr,Sue Carr,Sandra Simpson,Bindu Gregary,Avinash Aujayeb,Stephen Zingwe,Rubina Reza,Laura J. Gray,Kamlesh Khunti,Manish Pareek,Manish Pareek +25 more
TL;DR: For example, the authors found that despite increased risk of COVID-19, HCWs from some ethnic minority groups are more likely to be vaccine hesitant than their White British colleagues.
Journal ArticleDOI
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
A. Mesut Erzurumluoglu,Mengzhen Liu,Victoria E. Jackson,Victoria E. Jackson,Victoria E. Jackson,Daniel R. Barnes,Gargi Datta,Gargi Datta,Carl A. Melbourne,Robin Young,Chiara Batini,Praveen Surendran,Tao Jiang,Sheikh Daud Adnan,Saima Afaq,Arpana Agrawal,Elisabeth Altmaier,Antonis C. Antoniou,Folkert W. Asselbergs,Clemens Baumbach,Laura J. Bierut,Sarah Bertelsen,Michael Boehnke,Michiel L. Bots,David M. Brazel,John C. Chambers,Jenny Chang-Claude,Jenny Chang-Claude,Chu Chen,Chu Chen,Janie Corley,Yi-Ling Chou,Sean P. David,Rudolf A. de Boer,Christiaan de Leeuw,Joe Dennis,Anna F. Dominiczak,Alison M. Dunning,Douglas F. Easton,Charles B. Eaton,Paul Elliott,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Tatiana Foroud,Alison Goate,Jian Gong,Hans J. Grabe,Jeffrey Haessler,Christopher A. Haiman,Göran Hallmans,Anke R. Hammerschlag,Sarah E. Harris,Andrew T. Hattersley,Andrew C. Heath,Chris Hsu,William G. Iacono,Stavroula Kanoni,Manav Kapoor,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Jukka Kontto,Jaspal S. Kooner,Charles Kooperberg,Charles Kooperberg,Kari Kuulasmaa,Markku Laakso,Dongbing Lai,Claudia Langenberg,Nhung Le,Guillaume Lettre,Guillaume Lettre,Anu Loukola,Jian'an Luan,Pamela A. F. Madden,Massimo Mangino,Massimo Mangino,Riccardo E. Marioni,Eirini Marouli,Jonathan Marten,Nicholas G. Martin,Matt McGue,Kyriaki Michailidou,Kyriaki Michailidou,Evelin Mihailov,Alireza Moayyeri,Marie Moitry,Martina Müller-Nurasyid,Aliya Naheed,Matthias Nauck,Matt Neville,Matt Neville,Sune F. Nielsen,Kari E. North,Markus Perola,Markus Perola,Paul D.P. Pharoah,Giorgio Pistis,Tinca J. C. Polderman,Danielle Posthuma,Neil Poulter,Beenish Qaiser,Asif Rasheed,Alex P. Reiner,Alex P. Reiner,Frida Renström,Frida Renström,John P. Rice,Rebecca Rohde,Olov Rolandsson,Nilesh J. Samani,Maria Samuel,David Schlessinger,Steven Scholte,Robert A. Scott,Peter S. Sever,Peter S. Sever,Yaming Shao,Nick Shrine,Jennifer A. Smith,John M. Starr,Kathleen Stirrups,Kathleen Stirrups,Danielle Stram,Heather M. Stringham,Ioanna Tachmazidou,Jean-Claude Tardif,Jean-Claude Tardif,Deborah J. Thompson,Hilary A. Tindle,Vinicius Tragante,Stella Trompet,Valérie Turcot,Jessica Tyrrell,Ilonca Vaartjes,Andries R. van der Leij,Peter van der Meer,Tibor V. Varga,Niek Verweij,Niek Verweij,Henry Völzke,Nicholas J. Wareham,Helen R. Warren,David R. Weir,Stefan Weiss,Stefan Weiss,Leah Wetherill,Hanieh Yaghootkar,Ersin Yavas,Ersin Yavas,Yu Jiang,Fang Chen,Xiaowei Zhan,Weihua Zhang,Weihua Zhang,Wei Zhao,Kaixin Zhou,Philippe Amouyel,Stefan Blankenberg,Mark J. Caulfield,Rajiv Chowdhury,Francesco Cucca,Ian J. Deary,Panos Deloukas,Panos Deloukas,Panos Deloukas,Emanuele Di Angelantonio,Emanuele Di Angelantonio,Marco M Ferrario,Jean Ferrières,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Philippe M. Frossard,Ian P. Hall,Caroline Hayward,Jan-Håkan Jansson,J. Wouter Jukema,Frank Kee,Satu Männistö,Andres Metspalu,Patricia B. Munroe,Børge G. Nordestgaard,Colin N. A. Palmer,Veikko Salomaa,Naveed Sattar,Tim D. Spector,David P. Strachan,Pim van der Harst,Eleftheria Zeggini,Danish Saleheen,Danish Saleheen,Adam S. Butterworth,Adam S. Butterworth,Louise V. Wain,Louise V. Wain,Gonçalo R. Abecasis,John Danesh,John Danesh,John Danesh,Martin D. Tobin,Martin D. Tobin,Scott I. Vrieze,Dajiang J. Liu,Joanna M. M. Howson +206 more
TL;DR: The novel loci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the identification of potential drug targets for smoking prevention and/or cessation.
Journal ArticleDOI
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
David M. Brazel,Yu Jiang,Jordan M. Hughey,Valérie Turcot,Valérie Turcot,Xiaowei Zhan,Jian Gong,Chiara Batini,J. Dylan Weissenkampen,Mengzhen Liu,Praveen Surendran,Robin Young,Daniel R. Barnes,Sune F. Nielsen,Asif Rasheed,M Samuel,Wei Zhao,Jukka Kontto,Markus Perola,Muriel Caslake,Anton J. M. De Craen,S. Trompet,Maria Uria-Nickelsen,Anders Mälarstig,Dermot F. Reily,Maarten Hoek,Thomas F. Vogt,J. Wouter Jukema,Naveed Sattar,Ian Ford,Chris J. Packard,Dewan S. Alam,Abdulla Al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Philippe M. Frossard,Børge Grønne Nordestgaard,Danish Saleheen,J Danesh,Adam S. Butterworth,Joanna M. M. Howson,A. Mesut Erzurumluoglu,Victoria E. Jackson,Carl A. Melbourne,Tibor V. Varga,Helen R. Warren,Vinicius Tragante,Ioanna Tachmazidou,Sarah E. Harris,Evangelos Evangelou,Jonathan Marten,Weihua Zhang,Weihua Zhang,Elisabeth Altmaier,Jian'an Luan,Claudia Langenberg,Robert A. Scott,Hanieh Yaghootkar,Kathleen Stirrups,Stavroula Kanoni,Eirini Marouli,F Karpe,Anna F. Dominiczak,Peter S. Sever,Neil Poulter,Olov Rolandsson,Clemens Baumbach,Saima Afaq,John C. Chambers,Jaspal S. Kooner,Nicholas J. Wareham,Frida Renström,Göran Hallmans,Riccardo E. Marioni,Janie Corley,John M. Starr,Niek Verweij,Rudolf A. de Boer,Peter van der Meer,Ersin Yavas,Ilonca Vaartjes,Michiel L. Bots,Folkert W. Asselbergs,Hans J. Grabe,Henry Völzke,Matthias Nauck,Stefan Weiss,Paul D.P. Pharoah,Alison M. Dunning,Joe Dennis,Deborah J. Thompson,Kyriaki Michailidou,Douglas F. Easton,Antonis C. Antoniou,Jessica Tyrrell,Evelin Mihailov,Nilesh J. Samani,Kaixin Zhou,Matt J. Neville,Andres Metspalu,Colin N. A. Palmer,Ian P. Hall,David P. Strachan,Ian J. Deary,Timothy M. Frayling,Caroline Hayward,Pim van der Harst,Eleftheria Zeggini,Patricia B. Munroe,Jan-Håkan Jansson,Paul W. Franks,Panos Deloukas,Mark J. Caulfield,Louise V. Wain,Martin D. Tobin,Sarah Bertelsen,Yi Ling Chou,Jessica D. Faul,Jeff Haessler,Anke R. Hammerschlag,Chris Hsu,Manav Kapoor,Dongbing Lai,Nhung Le,Christiaan de Leeuw,Anu Loukola,Massimo Mangino,Massimo Mangino,Giorgio Pistis,Beenish Qaiser,Rebecca Rohde,Yaming Shao,Heather M. Stringham,Leah Wetherill,Arpana Agrawal,Laura J. Bierut,Chu Chen,Chu Chen,Charles B. Eaton,Alison Goate,Christopher A. Haiman,Andrew C. Heath,William G. Iacono,Nicholas G. Martin,Tinca J. C. Polderman,Alex P. Reiner,Alex P. Reiner,John P. Rice,David Schlessinger,H. Steven Scholte,Jennifer A. Smith,Jean-Claude Tardif,Jean-Claude Tardif,Hilary A. Tindle,Andries R. van der Leij,Michael Boehnke,Jenny Chang-Claude,Francesco Cucca,Sean P. David,Tatiana Foroud,Sharon L.R. Kardia,Charles Kooperberg,Markku Laakso,Guillaume Lettre,Guillaume Lettre,Pamela A. F. Madden,Matt McGue,Kari E. North,Danielle Posthuma,Tim D. Spector,Daniel O. Stram,David R. Weir,Jaakko Kaprio,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Dajiang J. Liu,Scott I. Vrieze +185 more
TL;DR: Fine-mapping genome-wide association study loci identifies specific variants contributing to the biological etiology of substance use behavior, including nonsynonymous/loss-of-function coding variants.