J
Jan Reedijk
Researcher at Leiden University
Publications - 1165
Citations - 45902
Jan Reedijk is an academic researcher from Leiden University. The author has contributed to research in topics: Ligand & Crystal structure. The author has an hindex of 80, co-authored 1163 publications receiving 43747 citations. Previous affiliations of Jan Reedijk include Nagoya City University & University of Münster.
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Journal Article
Pharmaceutical quality control of the investigational polymer-conjugated platinum anticancer agent AP 5280.
M. Bouma,Bastiaan Nuijen,Donald R. Stewart,Kevin F. Shannon,John V. St. John,John R. Rice,Remko Harms,Bart A. J. Jansen,Steven van Zutphen,Jan Reedijk,Auke Bult,Jos H. Beijnen +11 more
TL;DR: The combined results of the analyses performed on AP 5280 drug substance provided a meaningful picture of its structure, size, and integrity--an excellent basis for its quality control.
Journal ArticleDOI
An unusual Cu(II) complex of a Schiff-base ligand of 3-aminoquinoline with a hydronated pyridine unit: Synthesis, characterizations, and computational studies
Sanjit Nayak,Sanjit Nayak,Andrej Pevec,Colin C. Seaton,Patrick Gamez,Patrick Gamez,Jan Reedijk,Jan Reedijk +7 more
TL;DR: A very unusual Cu(II) compound of formula [Cu(mqmp)2(ClO4)2] was synthesized in situ from a one-pot reaction between copper(II)-perchlorate and a Schiff base ligand, abbreviated mqmp. The resulting compound, bearing positively charged side groups was characterized using single-crystal X-ray diffraction, elemental analysis, electrospray-ionization mass spectrometry (ESI-MS), infrared spectroscopy (IR), ligand-field (LF) spectrosc
Journal ArticleDOI
Crystal structure and spectroscopy of bis-[bis(2-benzimidazolyl)propane]copper(II) bis(triflate)monohydrate, a copper complex with a geometry intermediate between tetrahedral and square planar
TL;DR: The structure of a mononuclear copper(II) compound with the ligand bis(2-benzimidazolyl)propane (abbreviated as tbz) is reported in this article.
Journal ArticleDOI
Synthesis, crystal structure and electrochemical properties of [NBu4][Ni(mdt)2]: a potential precursor for new materials (mdt = 1,3-dithiole-4,5-dithiolate)
Yvonne S. J. Veldhuizen,Nora Veldman,Anthony L. Spek,Patrick Cassoux,Roger Carlier,Martijn J. Mulder,Jaap G. Haasnoot,Jan Reedijk +7 more
TL;DR: In this article, the reaction of methylenedithio-1,3-dithiol-2-one with sodium methanolate resulted in the anionic ligand mdt2- (mdt ǫ = 1,3dithiole-4,5-ditiolate) which has been co-ordinated to nickel.
Book ChapterDOI
Specific Binding of cis-Platinum Compounds to DNA and DNA Fragments
TL;DR: The high Cl- concentration in the blood prevents the hydrolysis of cis-Pt, which is a prerequisite for fast reaction, however, hydroleysis does occur inside the cells after penetration through the cell membrane.