J
Jerrold M. Olefsky
Researcher at University of California, San Diego
Publications - 606
Citations - 83310
Jerrold M. Olefsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 143, co-authored 595 publications receiving 77356 citations. Previous affiliations of Jerrold M. Olefsky include University of Colorado Boulder & University of Michigan.
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Journal ArticleDOI
Macrophages, Inflammation, and Insulin Resistance
TL;DR: Strategies focused on inhibiting the inflammation/insulin resistance axis that otherwise preserve essential innate immune functions may hold promise for therapeutic intervention.
Journal ArticleDOI
GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-Inflammatory and Insulin Sensitizing Effects
Da Young Oh,Saswata Talukdar,Eun Ju Bae,Takeshi Imamura,Hidetaka Morinaga,WuQiang Fan,Pingping Li,Wendell J. Lu,Steven M. Watkins,Jerrold M. Olefsky +9 more
TL;DR: GPR120 is a functional omega-3 FA receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation.
Journal ArticleDOI
IKK-beta links inflammation to obesity-induced insulin resistance.
Melek C. Arkan,Andrea L. Hevener,Florian R. Greten,Shin Maeda,Zhi-Wei Li,Jeffrey M. Long,Anthony Wynshaw-Boris,Giuseppe Poli,Jerrold M. Olefsky,Michael Karin +9 more
TL;DR: The importance of liver cell IKK-β in hepatic insulin resistance and the central role of myeloid cells in development of systemic insulin resistance are demonstrated and it is suggested that inhibition of Ikk-β, especially in myeloids cells, may be used to treat insulin resistance.
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Jill C. Milne,Philip D. Lambert,Simon Schenk,David P. Carney,J. Joshua Smith,David J. Gagne,Lei Jin,Olivier Boss,Robert B. Perni,Chi B. Vu,Jean Bemis,Roger Xie,Jeremy S. Disch,Pui Yee Ng,Joseph J. Nunes,Amy V. Lynch,Hongying Yang,Heidi Galonek,Kristine Israelian,Wendy Choy,Andre Iffland,Siva Lavu,Oliver Medvedik,David A. Sinclair,Jerrold M. Olefsky,Michael R. Jirousek,Peter J. Elliott,Christoph H. Westphal +27 more
TL;DR: These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates and improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver.
Journal ArticleDOI
The cellular and signaling networks linking the immune system and metabolism in disease
Olivia Osborn,Jerrold M. Olefsky +1 more
TL;DR: This work discusses how various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver.