J
Jihwan Park
Researcher at University of Pennsylvania
Publications - 53
Citations - 3736
Jihwan Park is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 23, co-authored 45 publications receiving 2125 citations. Previous affiliations of Jihwan Park include Gwangju Institute of Science and Technology & Pohang University of Science and Technology.
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Journal ArticleDOI
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Jihwan Park,Rojesh Shrestha,Chengxiang Qiu,Ayano Kondo,Shizheng Huang,Max Werth,Mingyao Li,Jonathan Barasch,Katalin Susztak +8 more
TL;DR: It is inferred that inherited kidney diseases that arise from distinct genetic mutations but share the same phenotypic manifestation originate from the same differentiated cell type, and that the collecting duct in kidneys of adult mice generates a spectrum of cell types through a newly identified transitional cell.
Journal ArticleDOI
Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
TL;DR: A new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference, which enables the characterization of cellular heterogeneity of complex tissues for understanding of disease mechanisms.
Journal ArticleDOI
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri,Jacklyn N. Hellwege,Jacob M. Keaton,Jacob M. Keaton,Jihwan Park,Chengxiang Qiu,Helen R. Warren,Helen R. Warren,Eric S. Torstenson,Eric S. Torstenson,Csaba P. Kovesdy,Yan V. Sun,Otis D. Wilson,Otis D. Wilson,Cassianne Robinson-Cohen,Christianne L. Roumie,Cecilia P. Chung,K A Birdwell,K A Birdwell,Scott M. Damrauer,Scott L. DuVall,Derek Klarin,Kelly Cho,Yu Wang,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,Claudia P. Cabrera,Louise V. Wain,Louise V. Wain,Rojesh Shrestha,Brian S. Mautz,Elvis A. Akwo,Muralidharan Sargurupremraj,Stéphanie Debette,Michael Boehnke,Laura J. Scott,Jian'an Luan,Zhao J-H.,Sara M. Willems,Sébastien Thériault,Nabi Shah,Nabi Shah,Christopher Oldmeadow,Peter Almgren,Ruifang Li-Gao,Niek Verweij,Thibaud Boutin,Massimo Mangino,Massimo Mangino,Ioanna Ntalla,Elena V. Feofanova,Praveen Surendran,James P. Cook,Savita Karthikeyan,Najim Lahrouchi,Ching-Ti Liu,Nuno Sepúlveda,Tom G. Richardson,Aldi T. Kraja,Philippe Amouyel,Martin Farrall,Neil Poulter,Markku Laakso,Eleftheria Zeggini,Peter S. Sever,Robert A. Scott,Claudia Langenberg,Nicholas J. Wareham,David Conen,Palmer Cna.,John Attia,Daniel I. Chasman,Paul M. Ridker,Olle Melander,Dennis O. Mook-Kanamori,Harst Pvd.,Francesco Cucca,David Schlessinger,Caroline Hayward,Tim D. Spector,Jarvelin M-R.,Branwen J. Hennig,Branwen J. Hennig,Nicholas J. Timpson,Wei W-Q.,J C Smith,Yaomin Xu,Michael E. Matheny,E E Siew,C M Lindgren,C M Lindgren,C M Lindgren,Herzig K-H.,George Dedoussis,Josh C. Denny,Bruce M. Psaty,Howson Jmm.,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Mark J. Caulfield,Mark J. Caulfield,Paul Elliott,Paul Elliott,J M Gaziano,J M Gaziano,John Concato,Wilson Pwf.,Philip S. Tsao,D.R. Velez Edwards,D.R. Velez Edwards,Katalin Susztak,Christopher J. O'Donnell,Adriana M. Hung,Adriana M. Hung,Todd L. Edwards,Todd L. Edwards +117 more
TL;DR: Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.
Journal ArticleDOI
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Ki Wung Chung,Poonam Dhillon,Shizheng Huang,Xin Sheng,Rojesh Shrestha,Chengxiang Qiu,Brett A. Kaufman,Jihwan Park,Liming Pei,Liming Pei,Joseph A. Baur,Matthew Palmer,Katalin Susztak +12 more
TL;DR: Ablation of STING ameliorated kidney fibrosis in mouse models of chronic kidney disease, demonstrating how TFAM sequesters mtDNA to limit the inflammation leading to fibrosis.
Journal ArticleDOI
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Monika A. Niewczas,Monika A. Niewczas,Meda E. Pavkov,Jan Skupien,Jan Skupien,Adam M. Smiles,Zaipul I. Md Dom,Zaipul I. Md Dom,Jonathan M. Wilson,Jihwan Park,Viji Nair,Andrew Schlafly,Pierre-Jean Saulnier,Pierre-Jean Saulnier,Eiichiro Satake,Eiichiro Satake,Christopher A Simeone,Hetal Shah,Hetal Shah,Chengxiang Qiu,Helen C. Looker,Paolo Fiorina,Paolo Fiorina,Carl F. Ware,Jennifer K. Sun,Jennifer K. Sun,Alessandro Doria,Alessandro Doria,Matthias Kretzler,Katalin Susztak,Kevin L. Duffin,Robert G. Nelson,Andrzej S. Krolewski,Andrzej S. Krolewski +33 more
TL;DR: These findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying end-stage renal disease development in both types of diabetes, and point to new therapeutic targets and new prognostic tests to identify subjects at risk of end-Stage renal disease.