J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill"
TL;DR: The evidence on pharmacological options for diabetes prevention is reviewed, in search of a medication that is efficacious, easy to adhere to, well tolerated, and cost‐effective.
Journal ArticleDOI
A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas.
Josephine H. Li,Lukasz Szczerbinski,Lukasz Szczerbinski,Adem Y. Dawed,Varinderpal Kaur,Varinderpal Kaur,Jennifer N. Todd,Jennifer N. Todd,Jennifer N. Todd,Ewan R. Pearson,Jose C. Florez +10 more
TL;DR: It is suggested that individuals with a higher genetic burden for T2D experience a greater acute and sustained response to sulfonylureas.
Journal ArticleDOI
National Down Syndrome Patient Database: Insights From the Development of a Multi-Center Registry Study
Jenifer Lavigne,Christianne Sharr,Al Ozonoff,Al Ozonoff,Lisa Albers Prock,Lisa Albers Prock,Nicole Bäumer,Nicole Bäumer,Campbell Brasington,Sheila Cannon,Blythe G. Crissman,Emily Davidson,Emily Davidson,Jose C. Florez,Priya S. Kishnani,Angela Lombardo,Jordan Lyerly,Jessica B. McCannon,Mary Ellen McDonough,Alison Schwartz,Kathryn L. Berrier,Susan Sparks,Kara Stock-Guild,Tomi L. Toler,Kishore Vellody,Lauren Voelz,Brian G. Skotko +26 more
TL;DR: The demographic distribution of participants enrolled, a detailed account of the database infrastructure, and lessons learned during the pilot year are reported to assist future researchers with similar goals for other patient populations are reported.
Journal ArticleDOI
Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program
Geoffrey A. Walford,Geoffrey A. Walford,Yong Ma,Costas A. Christophi,Ronald B. Goldberg,Ronald B. Goldberg,Petr Jarolim,Edward S. Horton,Edward S. Horton,Kieren J. Mather,Kieren J. Mather,Elizabeth Barrett-Connor,Elizabeth Barrett-Connor,Jaclyn Davis,Jaclyn Davis,Jose C. Florez,Jose C. Florez,Thomas J. Wang +17 more
TL;DR: Circulating NT-proBNP was associated with a measure of insulin sensitivity before and during preventive interventions for type 2 diabetes in the DPP and was consistent regardless of whether a participant was treated with placebo, intensive lifestyle intervention or metformin.
Journal ArticleDOI
The Kruppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
Jose C. Florez,Richa Saxena,Wendy Winckler,Noël P. Burtt,Peter Almgren,Kristina Bengtsson Boström,Tiinamaija Tuomi,Daniel Gaudet,Kristin G. Ardlie,Mark J. Daly,David Altshuler,Joel N. Hirschhorn,Leif Groop +12 more
TL;DR: It is concluded that the KLF11 A347S and T220M mutations do not contribute to increased risk of diabetes in European-derived populations and that the Q62R polymorphism has, at best, a minor effect on diabetes risk.