J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations
Jaeyoung Hong,Kathryn E. Hatchell,Jonathan P. Bradfield,Andrew Bjonnes,Alessandra Chesi,Chao-Qiang Lai,Carl D. Langefeld,Lingyi Lu,Yingchang Lu,Pamela L. Lutsey,Solomon K. Musani,Mike A. Nalls,Cassianne Robinson-Cohen,Jeffery D. Roizen,Richa Saxena,Katherine L. Tucker,Julie T. Ziegler,Dan E. Arking,Joshua C. Bis,Eric Boerwinkle,Erwin P. Bottinger,Donald W. Bowden,Vicente Gilsanz,Denise K. Houston,Heidi J. Kalkwarf,Andrea Kelly,Joan M. Lappe,Yongmei Liu,Erin D. Michos,Sharon E. Oberfield,Nicholette D. Palmer,Jerome I. Rotter,Bishwa Raj Sapkota,John A. Shepherd,James G. Wilson,Saonli Basu,Ian H. de Boer,Jasmin Divers,Barry I. Freedman,Struan F.A. Grant,Hakon Hakanarson,Tamara B. Harris,Bryan Kestenbaum,Stephen B. Kritchevsky,Ruth J. F. Loos,Jill M. Norris,Arnita F. Norwood,Jose M. Ordovas,James S. Pankow,Bruce M. Psaty,Bruce M. Psaty,Dharambir K. Sanghera,Lynne E. Wagenknecht,Babette S. Zemel,James B. Meigs,Josée Dupuis,Josée Dupuis,Jose C. Florez,Jose C. Florez,Thomas J. Wang,Ching-Ti Liu,Corinne D. Engelman,Liana K. Billings,Liana K. Billings +63 more
TL;DR: Ancestry-specific and transethnic GWASs of 25(OH)D confirmed findings in GC and DHCR7 for African and Hispanic American samples and revealed findings near KIF4B, ANO6/ARID2, and HTR2A; the biological mechanisms that link these regions with 25( OH)D metabolism warrant further investigation.
Journal ArticleDOI
Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels
TL;DR: The circadian oscillation of TPH constitutes the first described circadian rhythm of a chick pineal gene at the mRNA level, suggesting that TPH mRNA synthesis and/or turnover is regulated by an endogenous circadian clock in cultured chick Pineal cells.
Journal Article
Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways (Diabetes (2010) 59, (3229-3239))
Nicole Soranzo,Serena Sanna,Eleanor Wheeler,Christian Gieger,Dörte Radke,Josée Dupuis,Nabila Bouatia-Naji,Claudia Langenberg,Inga Prokopenko,Elliot S. Stolerman,Manjinder S. Sandhu,Matthew M. Heeney,Joseph M. Devaney,Muredach P. Reilly,Sally L. Ricketts,Alexandre F.R. Stewart,Benjamin F. Voight,Christina Willenborg,Benjamin J. Wright,David Altshuler,Dan E. Arking,Beverley Balkau,Daniel R. Barnes,Eric Boerwinkle,Bernhard O. Böhm,Amélie Bonnefond,Lori L. Bonnycastle,Dorret I. Boomsma,Stefan R. Bornstein,Yvonne Böttcher,Suzannah Bumpstead,Mary Susan Burnett-Miller,Harry Campbell,Antonio Cao,John C. Chambers,Robert Clark,Francis S. Collins,Josef Coresh,Eco J. C. de Geus,Mariano Dei,Panos Deloukas,Angela Döring,Josephine M. Egan,Roberto Elosua,Luigi Ferrucci,Nita G. Forouhi,Caroline S. Fox,Christopher S. Franklin,Maria Grazia Franzosi,Sophie Gallina,Anuj Goel,J. Graessler,Harald Grallert,Andreas Greinacher,David Hadley,Alistair S. Hall,Anders Hamsten,Caroline Hayward,Simon Heath,Christian Herder,Georg Homuth,Jouke-Jan Hottenga,Rachel Hunter-Merrill,Thomas Illig,Anne U. Jackson,Antti Jula,Marcus E. Kleber,Christopher W. Knouff,Augustine Kong,Jaspal S. Kooner,Anna Köttgen,Peter Kovacs,Knut Krohn,Brigitte Kühnel,Johanna Kuusisto,Markku Laakso,Mark Lathrop,Cécile Lecoeur,Man Li,Mingyao Li,Ruth J. F. Loos,Jian'an Luan,Valeriya Lyssenko,Reedik Mägi,Patrik K. E. Magnusson,Anders Mälarstig,Massimo Mangino,María Teresa Martínez-Larrad,Winfried März,Wendy L. McArdle,Ruth McPherson,Christa Meisinger,Thomas Meitinger,Olle Melander,Karen L. Mohlke,Vincent Mooser,Mario A. Morken,Narisu Narisu,David M. Nathan,Matthias Nauck,Christopher J. O'Donnell,Konrad Oexle,Nazario Olla,James S. Pankow,Felicity Payne,John F. Peden,Nancy L. Pedersen,Leena Peltonen,Markus Perola,Markus Perola,Ozren Polasek,Eleonora Porcu,Daniel J. Rader,Wolfgang Rathmann,Samuli Ripatti,Samuli Ripatti,Ghislain Rocheleau,Michael Roden,Igor Rudan,Veikko Salomaa,Richa Saxena,David Schlessinger,Heribert Schunkert,Peter Schwarz,Udo Seedorf,Elizabeth Selvin,Manuel Serrano-Ríos,Peter Shrader,Angela Silveira,David S. Siscovick,Kjioung Song,Tim D. Spector,Kari Stefansson,Valgerdur Steinthorsdottir,David P. Strachan,Rona J. Strawbridge,Michael Stumvoll,Ida Surakka,Ida Surakka,Amy J. Swift,Toshiko Tanaka,Alexander Teumer,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Anke Tönjes,Gianluca Usala,Veronique Vitart,Henry Völzke,Henri Wallaschofski,Dawn M. Waterworth,Hugh Watkins,H.-Erich Wichmann,Sarah H. Wild,Gonneke Willemsen,Gordon H. Williams,James F. Wilson,Juliane Winkelmann,Alan F. Wright,Carina Zabena,Jing Hua Zhao,Stephen E. Epstein,Jeanette Erdmann,Hakon Hakonarson,Sekar Kathiresan,Kay-Tee Khaw,Robert Roberts,Nilesh J. Samani,Mark D. Fleming,Robert Sladek,Gonçalo R. Abecasis,Michael Boehnke,Philippe Froguel,Leif Groop,Mark I. McCarthy,W. H. Linda Kao,Jose C. Florez,Manuela Uda,Nicholas J. Wareham,Inês Barroso,James B. Meigs +179 more
TL;DR: This article calculated net reclassification of diabetes mellitus patients using a database of patients diagnosed with type 2 diabetes over a 12-month period and found that the number of patients with diabetes decreases with age and disease progression.
Journal ArticleDOI
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Robert A. Scott,Audrey Y. Chu,Audrey Y. Chu,Niels Grarup,Niels Grarup,Alisa K. Manning,Marie-France Hivert,Dmitry Shungin,Dmitry Shungin,Anke Tönjes,Ajay Yesupriya,Daniel R. Barnes,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Nicole L. Glazer,Anne U. Jackson,Zoltán Kutalik,Zoltán Kutalik,Vasiliki Lagou,Diana Marek,Diana Marek,Laura J. Rasmussen-Torvik,Heather M. Stringham,Toshiko Tanaka,Mette Aadahl,Dan E. Arking,Sven Bergmann,Sven Bergmann,Eric Boerwinkle,Lori L. Bonnycastle,Stefan R. Bornstein,Eric J. Brunner,Suzannah Bumpstead,Soren Brage,Olga D. Carlson,Han Chen,Yii-Der Ida Chen,Peter S. Chines,Francis S. Collins,David Couper,Elaine M. Dennison,Nicole F. Dowling,Josephine S. Egan,Ulf Ekelund,Michael R. Erdos,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Mark O. Goodarzi,Jürgen Grässler,Stefan Gustafsson,Göran Hallmans,Torben Hansen,Torben Hansen,Torben Hansen,Aroon D. Hingorani,John W. Holloway,Frank B. Hu,Bo Isomaa,Karen A. Jameson,Ingegerd Johansson,Anna Jonsson,Torben Jørgensen,Mika Kivimäki,Peter Kovacs,Meena Kumari,Johanna Kuusisto,Markku Laakso,Cécile Lecoeur,Cécile Lecoeur,Claire Levy-Marchal,Guo Li,Ruth J. F. Loos,Valeri Lyssenko,Michael Marmot,Pedro Marques-Vidal,Mario A. Morken,Gabriele Müller,Kari E. North,James S. Pankow,Felicity Payne,Inga Prokopenko,Bruce M. Psaty,Bruce M. Psaty,Frida Renström,Frida Renström,Kenneth Rice,Jerome I. Rotter,Denis Rybin,Camilla H. Sandholt,Camilla H. Sandholt,Avan Aihie Sayer,Peter Shrader,Peter Schwarz,David S. Siscovick,Alena Stančáková,Michael Stumvoll,Tanya M. Teslovich,Gerard Waeber,Gordon H. Williams,Daniel R. Witte,Andrew R. Wood,Weijia Xie,Michael Boehnke,Cyrus Cooper,Luigi Ferrucci,Philippe Froguel,Leif Groop,W. H. Linda Kao,Peter Vollenweider,Mark Walker,Richard M. Watanabe,Oluf Pedersen,James B. Meigs,Erik Ingelsson,Inês Barroso,Inês Barroso,Jose C. Florez,Jose C. Florez,Paul W. Franks,Paul W. Franks,Paul W. Franks,Josée Dupuis,Josée Dupuis,Nicholas J. Wareham,Claudia Langenberg +125 more
TL;DR: In this large study of gene–lifestyle interaction, no interactions between genetic and lifestyle factors are observed, and top loci from genome-wide association studies will not make the best candidates for the study of interactions.
Journal ArticleDOI
TCF7L2 Polymorphism, Weight Loss and Proinsulin∶Insulin Ratio in the Diabetes Prevention Program
Jeanne M. McCaffery,Jeanne M. McCaffery,Kathleen A. Jablonski,Paul W. Franks,Samuel Dagogo-Jack,Rena R. Wing,William C. Knowler,Linda M. Delahanty,Dana Dabelea,Richard F. Hamman,Alan R. Shuldiner,Alan R. Shuldiner,Jose C. Florez,Jose C. Florez +13 more
TL;DR: The combination of a lack of impact of the TCF7L2 genotypes on the ability to lose weight, but the presence of a consistent effect on the proinsulin∶insulin ratio over the course of DPP, suggests that high-risk genotype carriers at this locus can successfully lose weight to counter diabetes risk despite persistent deficits in insulin production.