J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program
Geoffrey A. Walford,Geoffrey A. Walford,Yong Ma,Costas A. Christophi,Ronald B. Goldberg,Ronald B. Goldberg,Petr Jarolim,Edward S. Horton,Edward S. Horton,Kieren J. Mather,Kieren J. Mather,Elizabeth Barrett-Connor,Elizabeth Barrett-Connor,Jaclyn Davis,Jaclyn Davis,Jose C. Florez,Jose C. Florez,Thomas J. Wang +17 more
TL;DR: In this paper, the relationship between measures of adiposity, insulin sensitivity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the Diabetes Prevention Program (DPP) was investigated.
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Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.
Jordi Merino,Hassan S. Dashti,Hassan S. Dashti,Chloé Sarnowski,Jacqueline M. Lane,Jacqueline M. Lane,Petar Todorov,Miriam S. Udler,Yanwei Song,Yanwei Song,Heming Wang,Heming Wang,Heming Wang,Jaegil Kim,Chandler Tucker,John N. Campbell,John N. Campbell,Toshiko Tanaka,Audrey Y. Chu,Linus T.-Y. Tsai,Tune H. Pers,Tune H. Pers,Daniel I. Chasman,Martin K. Rutter,Martin K. Rutter,Josée Dupuis,Jose C. Florez,Richa Saxena +27 more
TL;DR: Merino et al. as discussed by the authors presented a multivariate genome-wide association analysis of overall variation in dietary intake to account for the correlation between dietary carbohydrate, fat and protein in 282,271 participants of European ancestry from the UK Biobank and Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
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Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 Individuals Across 13 Cohorts
Daniel DiCorpo,Jessica Eva LeClair,Joanne B. Cole,Chloé Sarnowski,Fariba Ahmadizar,Lawrence F. Bielak,Anneke Blokstra,Erwin P. Bottinger,Layal Chaker,Yii-Derr Chen,Ye Chen,Paul S. de Vries,Tariq Faquih,Mohsen Ghanbari,Valborg Gudmundsdottir,Xiuqing Guo,Natalie R Hasbani,Dorina Ibi,M. Arfan Ikram,Maryam Kavousi,Hampton L. Leonard,Aaron Leong,Josep M. Mercader,Alanna C. Morrison,Girish N. Nadkarni,Mike A. Nalls,Raymond Noordam,Michael Preuss,Jennifer A. Smith,Stella Trompet,Petra Vissink,Jie Yao,Wei Zhao,Eric Boerwinkle,Mark O. Goodarzi,Vilmundur Gudnason,J. Wouter Jukema,Sharon L.R. Kardia,Ruth J. F. Loos,Ching-Ti Liu,Alisa K. Manning,Dennis O. Mook-Kanamori,James S. Pankow,H. Susan J. Picavet,Naveed Sattar,Eleanor M. Simonsick,W. M. Monique Verschuren,Ko Willems van Dijk,Jose C. Florez,Jerome I. Rotter,James B. Meigs,Josée Dupuis,Miriam S. Udler +52 more
TL;DR: The findings support that genetically driven pathways leading to T2D also predispose differentially to clinical outcomes, and suggest that cardiovascular disease risk and renal function may be impacted by these loci through their shared disease pathway.
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Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration.
Jennifer N. Todd,Jeffrey W. Kleinberger,Haichen Zhang,Shylaja Srinivasan,Sherida E. Tollefsen,Lynne L. Levitsky,Lorraine E. Levitt Katz,Jeanie B. Tryggestad,Fida Bacha,Giuseppina Imperatore,Jean M. Lawrence,Catherine Pihoker,Jasmin Divers,Jason Flannick,Jason Flannick,Dana Dabelea,Jose C. Florez,Toni I. Pollin +17 more
TL;DR: In this paper, the prevalence of maturity-onset diabetes of the young (MODY) was assessed in multiethnic youth under age 20 years with a clinical diagnosis of type 2 diabetes.
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Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
Brian H. Chen,Marie-France Hivert,Marie-France Hivert,Marjolein J. Peters,Luke C. Pilling,John D. Hogan,Lisa Pham,Lorna W. Harries,Caroline S. Fox,Stefania Bandinelli,Abbas Dehghan,Dena G. Hernandez,Albert Hofman,Jaeyoung Hong,Roby Joehanes,Roby Joehanes,Andrew D. Johnson,Peter J. Munson,Denis Rybin,Andrew B. Singleton,André G. Uitterlinden,Saixia Ying,Magic Investigators,David Melzer,Daniel Levy,Joyce B. J. van Meurs,Luigi Ferrucci,Jose C. Florez,Josée Dupuis,Josée Dupuis,James B. Meigs,James B. Meigs,Eric D. Kolaczyk +32 more
TL;DR: Integration of genomic and transcriptomic data implicate circulating IGF2BP2 mRNA levels associated with glucose and insulin homeostasis in the regulation of fasting insulin and fasting glucose.