J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
New susceptibility loci associated with kidney disease in type 1 diabetes.
Niina Sandholm,Niina Sandholm,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Eoin P. Brennan,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Elizabeth Swan,Cameron D. Palmer,Cameron D. Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Valma Harjutsalo,Bing He,Outi Heikkilä,Kustaa Hietala,Janne P. Kytö,Päivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May Österholm,Maija Parkkonen,Janne Pitkäniemi,Milla Rosengård-Bärlund,Markku Saraheimo,Cinzia Sarti,Jenny Söderlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki O. Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah L. Prior,Candace Guiducci,Daniel B. Mirel,Andrew M. Taylor,Andrew M. Taylor,S. Mohsen Hosseini,Hans-Henrik Parving,Hans-Henrik Parving,Peter Rossing,Peter Rossing,Lise Tarnow,Lise Tarnow,Claes Ladenvall,François Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Trégouët,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna Möllsten,D. Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn,Joel N. Hirschhorn,Catherine Godson,Jose C. Florez,Jose C. Florez,Per-Henrik Groop,Per-Henrik Groop,Alexander P. Maxwell,Alexander P. Maxwell +105 more
TL;DR: A meta-analysis of genome-wide association studies of T1D DN revealed association of two SNPs with ESRD in the AFF3 gene and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, which represent new signals in the pathogenesis of DN.
Journal ArticleDOI
A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction
Eugene P. Rhee,Clary B. Clish,Anahita Ghorbani,Martin G. Larson,Martin G. Larson,Sammy Elmariah,Elizabeth L. McCabe,Qiong Yang,Susan Cheng,Kerry A. Pierce,Amy Deik,Amanda Souza,Laurie A. Farrell,Carly Domos,Robert W. Yeh,Igor F. Palacios,Kenneth Rosenfield,Ramachandran S. Vasan,Ramachandran S. Vasan,Jose C. Florez,Thomas J. Wang,Caroline S. Fox,Caroline S. Fox,Robert E. Gerszten,Robert E. Gerszten +24 more
TL;DR: The addition of metabolite profiling to clinical data may significantly improve the ability to predict whether an individual will develop CKD by identifying predictors of renal risk that are independent of estimated GFR.
Journal ArticleDOI
The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants.
TL;DR: In this paper, the authors describe guidelines for genome and exome-wide association P-value thresholds needed to correct for multiple testing, explaining the impact of linkage disequilibrium thresholds for distinguishing independent variants, minor allele frequency and ancestry characteristics.
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Eleanor Wheeler,Aaron Leong,Ching-Ti Liu,Marie-France Hivert,Rona J. Strawbridge,Clara Podmore,Man Li,Jie Yao,Xueling Sim,Jaeyoung Hong,Audrey Y. Chu,Weihua Zhang,Xu Wang,Peng Chen,Nisa M. Maruthur,Bianca Porneala,Stephen J. Sharp,Yucheng Jia,Edmond K. Kabagambe,Li-Ching Chang,Wei-Min Chen,Cathy E. Elks,Daniel S. Evans,Qiao Fan,Franco Giulianini,Min Jin Go,Jouke-Jan Hottenga,Yao Hu,Anne U. Jackson,Stavroula Kanoni,Young-Jin Kim,Marcus E. Kleber,Claes Ladenvall,Cécile Lecoeur,Sing-Hui Lim,Yingchang Lu,Anubha Mahajan,Carola Marzi,Mike A. Nalls,Pau Navarro,Ilja M. Nolte,Lynda M. Rose,Denis Rybin,Serena Sanna,Yuan Shi,Daniel O. Stram,Fumihiko Takeuchi,Shu Pei Tan,Peter J. van der Most,Jana V. van Vliet-Ostaptchouk,Andrew Wong,Loic Yengo,Wanting Zhao,Anuj Goel,María Teresa Martínez Larrad,Doert Radke,Perttu Salo,Toshiko Tanaka,Erik P A Van Iperen,Gonçalo R. Abecasis,Saima Afaq,Behrooz Z. Alizadeh,Alain G. Bertoni,Amelia Bonnefond,Yvonne Boettcher,Erwin P. Bottinger,Harry Campbell,Olga D. Carlson,Chien-Hsiun Chen,Yoon Shin Cho,W. Timothy Garvey,Christian Gieger,Mark O. Goodarzi,Harald Grallert,Anders Hamsten,Catharina A. Hartman,Christian Herder,Chao A. Hsiung,Jie Huang,Michiya Igase,Masato Isono,Tomohiro Katsuya,Chiea Chuen Khor,Wieland Kiess,Katsuhiko Kohara,Peter Kovacs,Juyoung Lee,Wen-Jane Lee,Benjamin Lehne,Huaixing Li,Jianjun Liu,Stéphane Lobbens,Jian'an Luang,Valeriya Lyssenko,Thomas Meitinger,Tetsuro Miki,Iva Miljkovic,Sanghoon Moon,Antonella Mulas,Gabriele Mueller,Martina Mueller-Nurasyid,Ramaiah Nagaraja,Matthias Nauck,James S. Pankow,Ozren Polasek,Inga Prokopenko,Paula S. Ramos,Laura J. Rasmussen-Torvik,Wolfgang Rathmann,Stephen S. Rich,Neil R. Robertson,Michael Roden,Ronan Roussel,Igor Rudan,Robert A. Scott,William R. Scott,Bengt Sennblad,David S. Siscovick,Konstantin Strauch,Liang Sun,Morris A. Swertz,Salman M. Tajuddin,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,Anke Toenjes,Nicholas J. Wareham,Gonneke Willemsen,Tom Wilsgaard,Aroon D. Hingorani,Josephine M. Egan,Luigi Ferrucci,G. Kees Hovingh,Antti Jula,Mika Kivimäki,Meena Kumari,Inger Njølstad,Colin N. A. Palmer,Manuel Serrano Ríos,Michael Stumvoll,Hugh Watkins,Tin Aung,Matthias Blueher,Michael Boehnke,Dorret I. Boomsma,Stefan R. Bornstein,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Yduan-Tsong Chen,Ching-Yu Cheng,Francesco Cucca,Eco J. C. de Geus,Panos Deloukas,Michele K. Evans,Myriam Fornage,Yechiel Friedlander,Philippe Froguel,Leif Groop,Myron D. Gross,Tamara B. Harris,Caroline Hayward,Chew-Kiat Heng,Erik Ingelsson,Norihiro Kato,Bong-Jo Kim,Woon-Puay Koh,Jaspal S. Kooner,Antje Koerner,Diana Kuh,Johanna Kuusisto,Markku Laakso,Xu Lin,Yongmei Liu,Ruth J. F. Loos,Patrik K. E. Magnusson,Winfried Maerz,Mark I. McCarthy,Albertine J. Oldehinkel,Ken K. Ong,Nancy L. Pedersen,Mark A. Pereira,Annette Peters,Paul M. Ridker,Charumathi Sabanayagam,Michèle M. Sale,Danish Saleheen,Juha Saltevo,Peter Schwarz,Wayne Huey-Herng Sheu,Harold Snieder,Tim D. Spector,Yasuharu Tabara,Jaakko Tuomilehto,Rob M. van Dam,James G. Wilson,James F. Wilson,Bruce H. R. Wolffenbuttel,Tien Yin Wong,Jer-Yuarn Wu,Jian-Min Yuan,Alan B. Zonderman,Nicole Soranzo,Xiuqing Guo,David J. Roberts,Jose C. Florez,Robert Sladek,Josée Dupuis,Andrew P. Morris,E-Shyong Tai,Elizabeth Selvin,Jerome I. Rotter,Claudia Langenberg,Inês Barroso,James B. Meigs +214 more
TL;DR: In this article, the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance was investigated.
Journal ArticleDOI
The prevention of type 2 diabetes.
Jill P. Crandall,William C. Knowler,Steven E. Kahn,David G. Marrero,Jose C. Florez,George A. Bray,Steven M. Haffner,Mary A. Hoskin,David M. Nathan +8 more
TL;DR: Prevention strategies that can be implemented in routine clinical settings have been developed and evaluated, but widespread application has been limited by local financial considerations, even though cost-effectiveness might be achieved at the population level.