J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
TL;DR: A strong enrichment of drug target genes associated with T2D was detected, primarily driven by insulin and thiazolidinedione targets, which was replicated in an independent meta-analysis (Metabochip), illustrating the utility of this approach in identifying potential side effects.
Journal ArticleDOI
Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus.
Camille E. Powe,Michael Nodzenski,Octavious Talbot,Catherine Allard,Catherine M. Briggs,Marysa V. Leya,Patrice Perron,Patrice Perron,Luigi Bouchard,Jose C. Florez,Denise M. Scholtens,William L. Lowe,Marie-France Hivert +12 more
TL;DR: Despite the profound changes in glycemic physiology during pregnancy, genetic determinants of fasting glucose, fasting insulin, insulin secretion, and insulin sensitivity discovered outside of pregnancy influence GDM risk.
Journal ArticleDOI
Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program.
Kieren J. Mather,Costas A. Christophi,Kathleen A. Jablonski,William C. Knowler,Ronald B. Goldberg,Steven E. Kahn,Tim D. Spector,Zari Dastani,Dawn M. Waterworth,J. B. Richards,Tohru Funahashi,F. X. Pi-Sunyer,Toni I. Pollin,Jose C. Florez,Jose C. Florez,Paul W. Franks,Paul W. Franks +16 more
TL;DR: In this article, the hypothesis that common variants in the genes encoding adiponectin (ADOQ) and its receptors (ADIPOR1, ADIPOR2) would associate with circulating adipomethienectin concentrations and/or with diabetes incidence in the Diabetes Prevention Program population was tested.
Journal ArticleDOI
Mendelian Randomization Analysis of Hemoglobin A1c as a Risk Factor for Coronary Artery Disease
Aaron Leong,Aaron Leong,Ji Chen,Eleanor Wheeler,Marie-France Hivert,Ching-Ti Liu,Jordi Merino,Jordi Merino,Josée Dupuis,E. Shyong Tai,Jerome I. Rotter,Jose C. Florez,Jose C. Florez,Inês Barroso,James B. Meigs,James B. Meigs +15 more
TL;DR: Genetic evidence supports a causal link between higher A1C and higher CAD risk, driven not only by glycemic but also by erythrocytic, glycemia-independent factors.
Journal ArticleDOI
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Goo Jun,Goo Jun,Alisa K. Manning,Marcio Almeida,Matthew Zawistowski,Andrew R. Wood,Tanya M. Teslovich,Tanya M. Teslovich,Christian Fuchsberger,Christian Fuchsberger,Shuang Feng,Pablo Cingolani,Kyle J. Gaulton,Thomas D. Dyer,Thomas W. Blackwell,Han Chen,Han Chen,Peter S. Chines,Sungkyoung Choi,Claire Churchhouse,Pierre Fontanillas,Ryan King,Sungyoung Lee,Stephen E. Lincoln,Vasily Trubetskoy,Mark A. DePristo,Tasha E. Fingerlin,Robert L. Grossman,Jason Grundstad,A. C. Heath,Jayoun Kim,Young-Jin Kim,Jason M. Laramie,Jae-Hoon Lee,Heng Li,Xuanyao Liu,Oren E. Livne,Adam E. Locke,Julian Maller,Alexander Mazur,Andrew P. Morris,Andrew P. Morris,Toni I. Pollin,Derek Ragona,David Reich,Manuel A. Rivas,Laura J. Scott,Xueling Sim,Xueling Sim,Rick Tearle,Yik Ying Teo,Yik Ying Teo,Amy L. Williams,Sebastian Zöllner,Joanne E. Curran,Juan M. Peralta,Beena Akolkar,Graeme I. Bell,Noël P. Burtt,Nancy J. Cox,Nancy J. Cox,Jose C. Florez,Jose C. Florez,Craig L. Hanis,Catherine McKeon,Karen L. Mohlke,Mark Seielstad,Mark Seielstad,James G. Wilson,Gil Atzmon,Gil Atzmon,Jennifer E. Below,Josée Dupuis,Dan L. Nicolae,Donna M. Lehman,Taesung Park,Sungho Won,Robert Sladek,David Altshuler,Mark I. McCarthy,Ravindranath Duggirala,Michael Boehnke,Timothy M. Frayling,Gonçalo R. Abecasis,John Blangero +84 more
TL;DR: The results from deep whole-genome analysis of large Mexican-American pedigrees are described, suggesting that large-effect rare variants account for only a modest fraction of the genetic risk of these traits in this sample of families.