J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Metabolite Profiles During Oral Glucose Challenge
Jennifer E. Ho,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Anahita Ghorbani,Susan Cheng,Susan Cheng,Eugene P. Rhee,Eugene P. Rhee,Jose C. Florez,Jose C. Florez,Clary B. Clish,Robert E. Gerszten,Robert E. Gerszten,Thomas J. Wang,Thomas J. Wang +16 more
TL;DR: It is suggested that unique metabolic phenotypes can be unmasked by OGTT in the prediabetic state and changes in 91 metabolites representing distinct biological pathways that are perturbed in response to an OGTT are demonstrated.
Journal ArticleDOI
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Minako Imamura,Atsushi Takahashi,Toshimasa Yamauchi,Kazuo Hara,Kazuo Hara,Kazuki Yasuda,Niels Grarup,Wei Zhao,Xu Wang,Alicia Huerta-Chagoya,Cheng Hu,Sanghoon Moon,Jirong Long,Soo Heon Kwak,Asif Rasheed,Richa Saxena,Ronald C.W. Ma,Yukinori Okada,Minoru Iwata,Jun Hosoe,Nobuhiro Shojima,Minaka Iwasaki,Hayato Fujita,Ken Suzuki,John Danesh,John Danesh,Torben Jørgensen,Torben Jørgensen,Marit E. Jørgensen,Daniel R. Witte,Ivan Brandslund,Cramer Christensen,Torben Hansen,Josep M. Mercader,Josep M. Mercader,Josep M. Mercader,Jason Flannick,Jason Flannick,Hortensia Moreno-Macías,Noël P. Burtt,Rong Zhang,Young-Jin Kim,Wei Zheng,Jai Rup Singh,Claudia H. T. Tam,Hiroshi Hirose,Hiroshi Maegawa,Chikako Ito,Kohei Kaku,Hirotaka Watada,Yasushi Tanaka,Kazuyuki Tobe,Ryuzo Kawamori,Michiaki Kubo,Yoon Shin Cho,Juliana C.N. Chan,Dharambir K. Sanghera,Philippe M. Frossard,Kyong Soo Park,Kyong Soo Park,Kyong Soo Park,Xiao-Ou Shu,Bong-Jo Kim,Jose C. Florez,Jose C. Florez,Teresa Tusié-Luna,Weiping Jia,E. Shyong Tai,Oluf Pedersen,Danish Saleheen,Shiro Maeda,Takashi Kadowaki +71 more
TL;DR: A meta-analysis of GWAS for T2D in the Japanese population indicates that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.
Journal ArticleDOI
Interactions of Dietary Whole-Grain Intake With Fasting Glucose– and Insulin-Related Genetic Loci in Individuals of European Descent: A meta-analysis of 14 cohort studies
Jennifer A. Nettleton,Nicola M. McKeown,Stavroula Kanoni,Rozenn N. Lemaitre,Hivert M-F.,Julius S. Ngwa,van Rooij Fja.,Emily Sonestedt,Mary K. Wojczynski,Zheng Ye,Toshiko Tanaka,Melissa E. Garcia,Jennifer S. Anderson,Jack L. Follis,Luc Djoussé,Kenneth J. Mukamal,Constantina Papoutsakis,Dariush Mozaffarian,M. C. Zillikens,Stefania Bandinelli,Amanda J. Bennett,Ingrid B. Borecki,Mary F. Feitosa,Luigi Ferrucci,Nita G. Forouhi,Christopher J. Groves,Göran Hallmans,Tamara B. Harris,Albert Hofman,Denise K. Houston,Frank B. Hu,Ingegerd Johansson,Stephen B. Kritchevsky,Claudia Langenberg,L. J. Launer,Yongmei Liu,Ruth J. F. Loos,Mike A. Nalls,Marju Orho-Melander,Frida Renström,Kenneth Rice,Ulf Risérus,Olov Rolandsson,Jerome I. Rotter,Georgia Saylor,Sijbrands Ejg.,Per Sjögren,A. Smith,Laufey Steingrimsdottir,André G. Uitterlinden,Nicholas J. Wareham,Inga Prokopenko,James S. Pankow,C M van Duijn,Jose C. Florez,Witteman Jcm.,Josée Dupuis,George Dedoussis,Jose M. Ordovas,Erik Ingelsson,L A Cupples,David S. Siscovick,Paul W. Franks,James B. Meigs +63 more
TL;DR: The results support the favorable association of whole- grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.
Journal ArticleDOI
Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus.
Camille E. Powe,Catherine Allard,Marie-Claude Battista,Myriam Doyon,Luigi Bouchard,Jeffrey L. Ecker,Patrice Perron,Jose C. Florez,Ravi Thadhani,Marie-France Hivert +9 more
TL;DR: Heterogeneity of physiologic processes underlying hyperglycemia exists among women with gestational diabetes mellitus, and GDM with impaired insulin sensitivity confers a greater risk of adverse outcomes.
Journal ArticleDOI
Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial
Richard W. Grant,Kelsey O'Brien,Jessica L. Waxler,Jason L. Vassy,Linda M. Delahanty,Laurie Bissett,Robert C. Green,Robert C. Green,Katherine G. Stember,Candace Guiducci,Elyse R. Park,Jose C. Florez,James B. Meigs +12 more
TL;DR: Diabetes genetic risk counseling with currently available variants does not significantly alter self-reported motivation or prevention program adherence for overweight individuals at risk for diabetes.