J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Six-Year Diabetes Incidence After Genetic Risk Testing and Counseling: A Randomized Clinical Trial.
TL;DR: It is demonstrated in the Genetic Counseling/Lifestyle Change (GC/LC) Study that learning one’s genetic risk did not impact short-term weight loss or behavior change motivation among participants in a diabetes prevention program.
Journal ArticleDOI
Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis
TL;DR: Meta-analyses of genome-wide association studies (GWAS) and ongoing comprehensive sequencing experiments are yielding a plethora of genetic associations from an agnostic vantage point, which can open unsuspected windows into the pathophysiology of metabolic phenotypes, including type 1 and type 2 diabetes.
Posted ContentDOI
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body fat distribution
Anne E. Justice,Tugce Karaderi,Heather M. Highland,Kristin L. Young,Mariaelisa Graff,Yingchang Lu,Valérie Turcot,Paul L. Auer,Rebecca S. Fine,Xiuqing Guo,Claudia Schurmann,Adelheid Lempradl,Eirini Marouli,Anubha Mahajan,Thomas W. Winkler,Adam E. Locke,Carolina Medina-Gomez,Tõnu Esko,Sailaja Vedantam,Ayush Giri,Ken Sin Lo,Tamuno Alfred,Poorva Mudgal,Maggie C.Y. Ng,Nancy C Heard-Costa,Mary F. Feitosa,Alisa K. Manning,Sara M. Willems,Suthesh Sivapalaratnam,Gonçalo R. Abecasis,Dewan S. Alam,Matthew A. Allison,Philippe Amouyel,Zorayr Arzumanyan,Beverley Balkau,Lisa Bastarache,Sven Bergmann,Lawrence F. Bielak,Matthias Blüher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Böger,Jette Bork-Jensen,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Linda Broer,Amber A. Burt,Adam S. Butterworth,Mark J. Caulfield,Giancarlo Cesana,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Francis S. Collins,James P. Cook,Amanda J. Cox,David S. Crosslin,John Danesh,Paul I.W. de Bakker,Simon de Denus,Renée de Mutsert,George Dedoussis,Ellen W. Demerath,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Marcus Dörr,Fotios Drenos,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Myriam Fornage,Caroline S. Fox,Paul W. Franks,Nele Friedrich,Wei Gan,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Giorgia Girotto,Mathias Gorski,Harald Grallert,Niels Grarup,Megan L. Grove,Stefan Gustafsson,Jeffrey Haessler,Torben Hansen,Andrew T. Hattersley,Caroline Hayward,Iris M. Heid,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Yi-Jen Hung,Kristian Hveem,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Gail P. Jarvik,Yucheng Jia,Torben Jørgenson,Pekka Jousilahti,Johanne Marie Justesen,Bratati Kahali,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Frank Kee,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Peter Kovacs,Bernhard K. Krämer,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Wen-Jane Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Jian'an Luan,Leo-Pekka Lyytikäinen,Stuart MacGregor,Reedik Mägi,Satu Männistö,Gaëlle Marenne,Jonathan Marten,Nicholas Masca,Mark I. McCarthy,Karina Meidtner,Evelin Mihailov,Leena Moilanen,Marie Moitry,Dennis O. Mook-Kanamori,Anna Morgan,Andrew P. Morris,Martina Müller-Nurasyid,Patricia B. Munroe,Narisu Narisu,Christopher P. Nelson,Matt J. Neville,Ioanna Ntalla,Jeffrey R. O'Connel,Katharine R. Owen,Oluf Pedersen,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Ailith Pirie,Ozren Polasek,Olli T. Raitakari,Asif Rasheed,Chelsea K. Raulerson,Rainer Rauramaa,Dermot F. Reilly,Alex P. Reiner,Paul M. Ridker,Manuel A. Rivas,Neil R. Robertson,Antonietta Robino,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Blair H. Smith,Jennifer A. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Karin M. A. Swart,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Tönjes,Mina Torres,Emmanouil Tsafantakis,Jaakko Tuomilehto,André G. Uitterlinden,Matti Uusitupa,Cornelia M. van Duijn,Mauno Vanhala,Rohit Varma,Sita H. Vermeulen,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,He Zheng,Wei Zhou,M. Carola Zillikens,Fernando Rivadeneira,Ingrid B. Borecki,John Andrew Pospisilik,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Karen L. Mohlke,Jerome I. Rotter,Zoltán Kutalik,Joel N. Hirschhorn,L. Adrienne Cupples,Ruth J. F. Loos,Kari E. North,Cecilia M. Lindgren +278 more
TL;DR: By examining variants often poorly tagged or entirely missed by genome-wide association studies, novel genes in fat distribution are implicate, stressing the importance of interrogating low-frequency and protein-coding variants.
Journal ArticleDOI
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease
Hyunkyung Kim,Kenneth Westerman,Kirk E. Smith,Joshua Chiou,Joanne B. Cole,Timothy D. Majarian,Marcin von Grotthuss,Soo Heon Kwak,Jaegil Kim,Josep M. Mercader,Jose C. Florez,Kyle J. Gaulton,Alisa K. Manning,Miriam S. Udler +13 more
TL;DR: In this article , a high-throughput pipeline was developed to enable clustering of type 2 diabetes loci based on variant-trait associations and applied Bayesian non-negative matrix factorisation (bNMF) to identify genetic components of Type 2 diabetes.
Journal ArticleDOI
The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience
Neil H. White,Qing Pan,Emily B. Schroeder,Emily Y. Chew,Barbara A Blodi,Xavier Pi-Sunyer,Christine Darwin,Mathias Schlögl,David M. Nathan,Barry J. Goldstein,Kevin Furlong,Kellie Smith,J. T. Mendoza,W. W. Wildman,Marsha D. Simmons,Genine Jensen,R. Liberoni,John Spandorfer,C. Pepe,Richard P. Donahue,Ronald N. Goldberg,P. Rowe,A. Giannella,J. Calles,Juliet Sanguily,Paul Cassanova-Romero,Sumaya Castillo-Florez,Hermes Florez,Rajesh Garg,Lascelles Kirby,Olga Lara,Carmen A. Larreal,V. McLymont,J. Mendez,Arlette C. Perry,Patrice G. Saab,B. Veciana,Steven M. Haffner,Helen P. Hazuda,Maria G. Montez,J.J. Isaac,K. Hattaway,Carlos Lorenzo,Arlene Martinez,Monica R. Salazar,Tatiana Walker,Richard F. Hamman,Dana Dabelea,Patricia Nash,Sheila Steinke,L. Testaverde,Jennifer T. Truong,Denise Anderson,Larry B. Ballonoff,Alexis Bouffard,Rebecca S. Boxer,Brian C. Bucca,B. Ned Calonge,Lynne Delve,Martha Farago,James O. Hill,S. R. Hoyer,T. Jenkins,Bonnie T. Jortberg,Dione Lenz,Marsha Miller,T.G. Nilan,Leigh Perreault,David W. Price,Judith G. Regensteiner,Helen M. Seagle,Carissa M. Smith,Brent VanDorsten,Edward S. Horton,Medha Munshi,K. E. Lawton,Catherine Serra Poirier,Kati Swift,S. D. Jackson,Ronald A. Arky,M. Bryant,J. P. Burke,E. Caballero,Karen M. Callaphan,Barbara Fargnoli,T. Franklin,Om P. Ganda,A. Guidi,Mathew Guido,A. M. Jacobsen,L. M. Kula,M. Kocal,Lori Lambert,Sarah Ledbury,M. A. Malloy,Roeland J.W. Middelbeek,M. Nicosia,C. F. Oldmixon,Jocelyn Yu Pan,M. Quitingon,Riley Rainville,S. Rubtchinsky,Ellen W. Seely,Jessica Sansoucy,D. Schweizer,Donald C. Simonson,Fannie Smith,Caren G. Solomon,Jeanne Spellman,James H. Warram,Steven E. Kahn,Brenda Montgomery,B. Fattaleh,C. B. Colegrove,Wilfred Y. Fujimoto,Robert H. Knopp,Edward W. Lipkin,Michelle Marr,Ivy Morgan-Taggart,Anne Murillo,Kayla O’Neal,Dace L. Trence,Lonnese Taylor,April Thomas,Elaine Tsai,Abbas E. Kitabchi,Samuel Dagogo-Jack,Mary E. Murphy,Laura Taylor,Jennifer Dolgoff,Ethel Faye Hampton,William B. Applegate,Michael Bryer-Ash,Debra L. Clark,Sandra L. Frieson,Uzoma N. Ibebuogu,Raed Imseis,Helen Lambeth,Lynne Lichtermann,Hooman Oktaei,H. Ricks,L. M. Rutledge,Amy R. Sherman,Clara Mabel Smith,Judith E. Soberman,Beverly Williamsleaves,Avnisha Patel,Ebenezer Nyenwe,Boyd E. Metzger,Mark E. Molitch,Amisha Wallia,Mariana K. Johnson,Sarah VanderMolen,Daphne T. Adelman,Catherine Behrends,Michelle Westerman Cook,Marian L. Fitzgibbon,Mimi M. Giles,M. Hartmuller,C. Johnson,Diane Larsen,Anne Susan Lowe,Megan Lyman,D McPherson,Samsam C. Penn,Thomas H. Pitts,Renee Reinhart,Susan M Roston,Pamela Schinleber,Charles McKitrick,H. Turgeon,Mary Larkin,Marielle T Mugford,Nopporn Thangthaeng,Fernelle Leander,Kathy Abbott,Ellen J. Anderson,Laurie Bissett,Kristy-Ann Bondi,Enrico Cagliero,Jose C. Florez,Linda M. Delahanty,Valerie Goldman,Elaine Grassa,Lindsey Gurry,Kali Nicole D'Anna,Fernelle Leandre,P. Lou,Alexandra Poulos,Elyse Raymond,Valerie Ripley,Christin E. Stevens,Beverly Tseng,Jerrold M. Olefsky,Elizabeth Barrettonnor,Sunder Mudaliar,Maria Rosario Araneta,Mary Lou Carrion-Petersen,Karen Vejvoda,Sarah S Bassiouni,Madeline Beltran,Lauren N. Claravall,Jonalle M. Dowden,Steven V. Edelman,Pranav S. Garimella,Robert R. Henry,Javiva Horne,Marycie Lamkin,Simona Szerdi Janesch,Diana Leos,William H. Polonsky,Rosaura Ruiz,Jean Smith,Jennifer Torio-Hurley,F. Xavier Pi-Sunyer,Blandine Laferrère,Jane E. Lee,Susan Hagamen,Kim Kelly-Dinham,David B. Allison,Nnenna Agharanya,Nancy J Aronoff,Mara Del Baldo,Jill P. Crandall,Sandra Foo,José A. Luchsinger,Carmen Pal,Kathy Parkes,Mary Beth Pena,Julienne Roman,Eileen Rooney,Gretchen E.H. VanWye,Kristine A. Viscovich,Melvin J. Prince,David G. Marrero,Kieren J. Mather,N. De Groot,Susie Kelly,Marcia A. Jackson,G. E. Mcatee,Paula Putenney,Ronald T. Ackermann,Carolyn M. Cantrell,Yolanda F. Dotson,Edwin S. Fineberg,Megan Fultz,John Guare,Angela M. Hadden,James M. Ignaut,M. Sue Kirkman,Erin O'Kelly Phillips,Kisha L. Pinner,Beverly Porter,Paris Roach,Nancy Rowland,Madelyn L. Wheeler,Robert E. Ratner,Vanita R. Aroda,Michelle F. Magee,Gretchen A. Youssef,Sue Shapiro,Natalie Andon,Catherine Bavido-Arrage,Geraldine Boggs,Marjorie Bronsord,Ernestine Brown,Holly Love Burkott,Wayman Wendell Cheatham,Susan Y Cola,Cindy Evans,Peggy Gibbs,Tracy Kellum,Lilian E. de Leon,Milvia Lagarda,Claresa Levatan,Milajurine T. Lindsay,Asha K. Nair,Jean Park,Maureen D. Passaro,A Silverman,Gabriel I. Uwaifo,Debra Wells-Thayer,Renee Wiggins,Mohammed F. Saad,Karol E. Watson,Maria Budget,Sujata Jinagouda,M.G.Z. Botrous,Anthony Sosa,S. Tadros,Khan Mohd Akbar,Claudia Conzues,Perpetua Magpuri,Kathy Ngo,Amer G. Rassam,Debra Waters,Kathy Xapthalamous,Julio V. Santiago,Angela L. Brown,Ana Cristina Santiago,Samia Das,Prajakta A. Khare-Ranade,Tamara Stich,Edwin B. Fisher,Emma Hurt,Jackie Jones,Tracy Jones,Michelle Kerr,Sherri McCowan,Lucy D. Ryder,Cormarie Wernimont,Christopher D. Saudek,Sherita Hill Golden,Vanessa Bradley,Emily Sullivan,Tracy Whittington,Caroline Abbas,Adrienne Allen,Frederick L. Brancati,S. Cappelli,Jeanne M. Clark,Jeanne Charleston,Janice Freel,Katherine Horak,Alicia Marie Greene,Dawn Jiggetts,Delois Johnson,Hope Joseph,Rita R. Kalyani,Kimberly Loman,Nestoras Mathioudakis,Nisa M. Maruthur,Henry Mosley,John Reusing,Richard R. Rubin,Alafia Samuels,Thomas Shields,Shawn S. Stephens,Kerry J. Stewart,Lee E. Thomas,E Utsey,Paula R Williamson,David S. Schade,Karwyn S. Adams,Carolyn Johannes,C. Dallett Hemphill,Penny Hyde,Janene L. Canady,Leslie F. Atler,Patrick J. Boyle,Mark R. Burge,Lisa Chai,Kathleen Colleran,Ateka Fondino,Ysela Gonzales,Doris A. Hernandez-McGinnis,Patricia Hawkins Katz,Carolyn King,Julia Middendorf,Sofya M Rubinchik,Willette Senter,Harry Shamoon,Janet Brown,Gilda Trandafirescu,Danielle Powell,Elsie Adorno,Liane Cox,H. Duffy,Samuel S. Engel,Allison Friedler,Angela Goldstein,Crystal J. Howardentury,Jennifer Lukin,Stacey Kloiber,Nadege Longchamp,H. Martinez,D. Pompi,Jonathan Scheindlin,Norica Tomuta,Elissa Violino,Elizabeth A. Walker,Judith Wylie-Rosett,Elise Zimmerman,Joel Zonszein,Rena R. Wing,Trevor J. Orchard,Elizabeth M. Venditti,Gaye M. Koenning,M. Kaye Kramer,Marietta Smith,Susan Jeffries,Valarie A. Weinzierl,Susan Barr,Catherine Benchoff,Miriam A. Boraz,Lisa Clifford,Rebecca J. Culyba,Marlene Frazier,Ryan Gilligan,Stephanie Guimond,Susan Harrier,Louann Harris,Andrea M. Kriska,Qurashia Manjoo,Monica Mullen,Alicia Noel,Amy D. Otto,Jessica L Pettigrew,Bonny Rockette-Wagner,Debra Rubinstein,Linda Semler,Cheryl F. Smith,Katherine V. Williams,Tara Wilson,Richard Arakaki,Marjorie K. Mau,Renee W. Latimer,M. Isonaga,Narleen K. Baker-Ladao,Ralph Bow,Nina Bermudez,Lorna Dias,Jillian Inouye,John S. Melish,Kathy Mikami,Pharis Mohideen,Sharon Kaʻiulani Odom,Raynette U. Perry,Robin E. Yamamoto,William C. Knowler,Robert L. Hanson,Vallabh O. Shah,Mary A. Hoskin,Carol Percy,Norman Cooeyate,Camille Natewa,Charlotte Peabody Dodge,Alvera Enote,Harelda Anderson,Kelly J. Acton,Vickie L. Andre,Rosalyn Barber,Shandiin Begay,Peter H. Bennett,Mary Beth Benson,Evelyn C. Bird,Brenda A. Broussard,Marcella Chavez,S.J. Cook,Jeffrey Curtis,Tara Dacawyma,Matthew S. Doughty,Roberta Duncan,Cyndy Edgerton,Jacqueline M. Ghahate,Justin Glass,Marti J. Glass,Dorothy Gohdes,Wendy Lyn Grant,Ellie Horse,Louise E. Ingraham,Merry Jackson,Priscilla Jay,Roylen S. Kaskalla,Karen G. Kavena,David Kessler,Kathy Kobus,Jonathan Krakoff,Jason Kurland,Catherine Manus,C. L. McCabe,Sara Michaels,Tina Morgan,Yolanda Nashboo,Julie Nelson,Steven Poirier,Evette Polczynski,Christopher S. Piromalli,Michael S. Reidy,Jeanine Roumain,Debra Rowse,Robert J. Roy,Sandra Sangster,Janet Sewenemewa,Miranda Smart,Chelsea Lee Spencer,Darryl Parker Tonemah,Rachel Williams,Charlton Wilson,Michelle Yazzie,Ray Bain,Sarah E. Fowler,Michael D. Larsen,Kathleen A. Jablonski,Marinella Temprosa,Tina Brenneman,Sharon L. Edelstein,Solome Abebe,Julie A. Bamdad,Melanie Barkalow,J. Bethepu,Tsedenia Bezabeh,Anna-Claire Bowers,Nicole A. Butler,Jackie Callaghan,Caitlin E. Carter,Costas A. Christophi,Gregory M. Dwyer,Mary A. Foulkes,Yuping Gao,Robert Gooding,Adrienne M. Gottlieb,Kristina L. Grimes,Nisha Grover-Fairchild,Lori Haffner,Heather J. Hoffman,Steve Jones,Tara Jones,Richard J. Katz,Preethy Kolinjivadi,John M. Lachin,Yong Ma,Pamela Mucik,Robert Orlosky,S. M. Reamer,James Rochon,Alla Sapozhnikova,Hanna Sherif,Charlotte Stimpson,Ashley Hogan Tjaden,Fredricka Walker-Murray,Valerie Weinzierl,Santica M. Marcovina,F. Alan Aldrich,J.E. Harting,J. M. Albers,Greg Strylewicz,Anthony A. Killeen,Deanna Gabrielson,Robert Edward Eastman,Judith E. Fradkin,Sanford A. Garfield,Christine G. Lee,Edward W. Gregg,Ming Zhang,D. O'Leary,Gregory M. Evans,Matthew J. Budoff,Chris Dailing,Elizabeth R. Stamm,Ann V. Schwartz,Caroline Navy,Lisa Palermo,Pentti M. Rautaharju,Ronald J. Prineas,Elsayed Z. Soliman,Teresa Alexander,Charles Campbell,Sharon Perkins Hall,Yabing Li,Margaret Mills,Nancy Pemberton,Farida Rautaharju,Zhu Ming Zhang,Julie Hu,S. Hensley,L.C. Keasler,Tonya Marie Taylor,Ronald P. Danis,M. Davis,Larry D. Hubbard,Ryan L. Endres,Deborah Elsas,Samantha Johnson,Dawn Myers,Nancy F. Barrett,Heather Baumhauer,Wendy Benz,Holly Cohn,E Corkery,Kristi Dohm,Amitha Domalpally,V. Gama,A. Goulding,Andrew Ewen,Cynthia Hurtenbach,Daniel Lawrence,Kyle McDaniel,Jeong W. Pak,J.L. Reimers,Ruth W. Shaw,Maria K. Swift,Pamela Vargo,Sheila D. Watson,J. E. Manly,Elizabeth J. Mayer-Davis,Robert Moran,Ted Ganiats,Kristin David,Andrew J. Sarkin,Erik J. Groessl,Naomi M. Katzir,Helen Chong.,William H. Herman,Michael Brändle,Morton B. Brown,David Altshuler,Liana K. Billings,Ling Chen,Maegan Harden,Toni I. Pollin,Alan R. Shuldiner,Paul W. Franks,Marie-France Hivert +613 more
TL;DR: Interventions that delay or prevent the onset of type 2 diabetes in overweight/obese subjects with dysglycemia who are at risk for diabetes do not reduce the development of diabetic retinopathy for up to 20 years.