J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism.
Geoffrey A. Walford,Todd Green,Todd Green,Benjamin M. Neale,Benjamin M. Neale,Tamara Isakova,Jerome I. Rotter,Struan F.A. Grant,Caroline S. Fox,James S. Pankow,James G. Wilson,James B. Meigs,David S. Siscovick,Donald W. Bowden,Mark J. Daly,Mark J. Daly,Jose C. Florez,Jose C. Florez +17 more
TL;DR: Common genetic risk variants at GCK, SLC30A8, IGF2BP2 and MTNR1B influence to different extents the development of IFG and the transition from IFG to type 2 diabetes.
Posted ContentDOI
Cardiometabolic Risk Factors for COVID-19 Susceptibility and Severity: A Mendelian Randomization Analysis.
TL;DR: Genetic evidence supports BMI as a causal risk factor for COVID-19 susceptibility and severity, and this relationship may be mediated via type 2 diabetes.
Journal ArticleDOI
Precision Medicine in Diabetes: Is It Time?
TL;DR: Despite extensive epidemiological and physiological characterization, the traditional classification into type 1 and type 2 diabetes has fallen short in cataloging risk factors, identifying triggering events, elucidating pathophysiological pathways, outlining prognostic course, selecting effective therapies, and predicting complications.
Journal ArticleDOI
Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism.
Toni I. Pollin,Kathleen A. Jablonski,Kathleen A. Jablonski,Jarred B. McAteer,Richa Saxena,Richa Saxena,Sekar Kathiresan,Sekar Kathiresan,Steven E. Kahn,Ronald B. Goldberg,David Altshuler,Jose C. Florez +11 more
TL;DR: Intensive lifestyle intervention appears to partially mitigate the effect of the 446L allele on higher triglycerides, whereas the P446 allele appears to enhance responsiveness to the HOMA-IR-lowering effect of metformin.
Journal ArticleDOI
Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis
TL;DR: In the U.S., a higher T2D genetic risk was associated with increased mortality risk, especially among obese NHW, and the underlying genetic basis for mortality likely involves complex interactions with factors related to ethnicity, T1D, and body weight.