J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program
Linda M. Delahanty,Qing Pan,Kathleen A. Jablonski,Karol E. Watson,Jeanne M. McCaffery,Alan R. Shuldiner,Steven E. Kahn,William C. Knowler,Jose C. Florez,Paul W. Franks +9 more
TL;DR: Investigating genetic associations with weight loss and weight regain in the Diabetes Prevention Program may help identify people who require additional support to maintain reduced weight after clinical intervention.
Journal ArticleDOI
A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study: Replication and Integration With Other Genome-Wide Datasets
Jose C. Florez,Alisa K. Manning,Josée Dupuis,Jarred B. McAteer,Kathryn Irenze,Lauren Gianniny,Daniel B. Mirel,Caroline S. Fox,L. Adrienne Cupples,James B. Meigs +9 more
TL;DR: The FHS 100K GWA resource is useful for follow-up of genetic associations with diabetes-related quantitative traits and discovery of new diabetes genes will require larger samples and a denser array combined with well-powered replication strategies.
Journal ArticleDOI
Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes
Jose C. Florez,Jose C. Florez,Alkes L. Price,Desmond Campbell,Laura Riba,María Victoria Parra,Fuli Yu,Fuli Yu,Fuli Yu,Constanza Duque,Richa Saxena,Richa Saxena,Natalia Gallego,Marcela K. Tello-Ruiz,Liliana Franco,Maribel Rodríguez-Torres,Alberto Villegas,Gabriel Bedoya,Carlos A. Aguilar-Salinas,Ma. Teresa Tusié-Luna,Andres Ruiz-Linares,Andres Ruiz-Linares,David Reich,David Reich +23 more
TL;DR: The proportion of non-European ancestry is associated with both type 2 diabetes and lower socioeconomic status in admixed Latino populations from North and South America, and ancestry-directed search for genetic markers associated with type 1 diabetes in Latinos may benefit from information involving social factors.
Journal ArticleDOI
Genomics of type 2 diabetes mellitus: implications for the clinician
TL;DR: The current list of genetic loci that are related to T2DM does not seem to offer greater predictive value in determining diabetes risk than do commonly used phenotypic risk factors and family history.
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The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.
Jarred B. McAteer,Jarred B. McAteer,Sabrina Prudente,Simonetta Bacci,Helen N. Lyon,Helen N. Lyon,Helen N. Lyon,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Vincenzo Trischitta,Jose C. Florez,Jose C. Florez +12 more
TL;DR: The ENPP1 Q121 variant increases risk of type 2 diabetes under a recessive model of inheritance in whites, an effect that appears to be modulated by BMI.