J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Regulation of Tryptophan Hydroxylase by Cyclic AMP, Calcium, Norepinephrine, and Light in Cultured Chick Pineal Cells
TL;DR: It is reported here that 35S incorporation into TPH is induced by cyclic AMP and calcium, and partially inhibited by acute exposure to light, which appears to be involved in both translational and posttranslational processes regulating the expression of TPH in chick pineal cells.
Journal ArticleDOI
The Influence of Rare Genetic Variation in SLC30A8 on Diabetes Incidence and β-Cell Function
Liana K. Billings,Kathleen A. Jablonski,Rachel J. Ackerman,Andrew W. Taylor,Andrew W. Taylor,Rebecca R. Fanelli,Jarred B. McAteer,Jarred B. McAteer,Candace Guiducci,Linda M. Delahanty,Dana Dabelea,Steven E. Kahn,Paul W. Franks,Paul W. Franks,Robert L. Hanson,Nisa M. Maruthur,Alan R. Shuldiner,Elizabeth J. Mayer-Davis,William C. Knowler,Jose C. Florez,Jose C. Florez +20 more
TL;DR: Individual common and an aggregate of rare genetic variation in SLC30A8 are associated with measures of β-cell function in the DPP and may complement ongoing efforts to uncover the genetic influences that underlie complex diseases.
Journal ArticleDOI
The role of HSP70 on ENPP1 expression and insulin-receptor activation.
Antonella Marucci,Giuseppe Miscio,Libera Padovano,Watip Boonyasrisawat,Watip Boonyasrisawat,Jose C. Florez,Jose C. Florez,Alessandro Doria,Alessandro Doria,Vincenzo Trischitta,Rosa Di Paola +10 more
TL;DR: HSP70, by affecting ENPP1 expression, may be a novel mediator of altered insulin signaling, as suggested by RNA electrophoresis mobility shift analysis and tandem mass spectrometry data.
Journal ArticleDOI
The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes
Geoffrey A. Walford,Natalia Colomo,Jennifer N. Todd,Liana K. Billings,Marlene Fernandez,Bindu Chamarthi,A. Sofia Warner,Jaclyn Davis,Katherine R. Littleton,Alicia M. Hernandez,Rebecca R. Fanelli,Amelia Lanier,Corinne Barbato,Rachel J. Ackerman,Sabina Q. Khan,Rosa Bui,Laurel Garber,Elliot S. Stolerman,Allan F. Moore,Chunmei Huang,Varinderpal Kaur,Maegan Harden,Andrew W. Taylor,Ling Chen,Alisa K. Manning,Paul L. Huang,Deborah J. Wexler,Rita M. McCarthy,Janet Lo,Melissa K. Thomas,Richard W. Grant,Allison B. Goldfine,Margo S. Hudson,Jose C. Florez +33 more
TL;DR: SUGAR-MGH represents a viable pharmacogenetic resource which, when completed, will serve to characterize genetic influences on pharmacological perturbations, and help establish the functional relevance of newly discovered genetic loci to therapy of type 2 diabetes.
Journal ArticleDOI
Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study.
James B. Meigs,Richard W. Grant,Rebecca S. Piccolo,Lenny Lopez,Jose C. Florez,Jose C. Florez,Bianca Porneala,Lisa D. Marceau,John B. McKinlay +8 more
TL;DR: A greater proportion of African genetic ancestry is independently associated with higher FG levels in a non-diabetic community-based cohort, even accounting for other ancestry proportions, obesity and SES.