J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Rare coding variants in 35 genes associate with circulating lipid levels – a multi-ancestry analysis of 170,000 exomes
George Hindy,George Hindy,George Hindy,Peter Dornbos,Peter Dornbos,Peter Dornbos,Mark Chaffin,Mark Chaffin,Dajiang J. Liu,Minxian X. Wang,Minxian X. Wang,Margaret Sunitha Selvaraj,Margaret Sunitha Selvaraj,David Zhang,Joseph Park,Carlos A. Aguilar-Salinas,Lucinda Antonacci-Fulton,Diego Ardissino,Donna K. Arnett,Stella Aslibekyan,Gil Atzmon,Gil Atzmon,Christie M. Ballantyne,Christie M. Ballantyne,Francisco Barajas-Olmos,Nir Barzilai,Lewis C. Becker,Lawrence F. Bielak,Joshua C. Bis,John Blangero,Eric Boerwinkle,Eric Boerwinkle,Lori L. Bonnycastle,Erwin P. Bottinger,Erwin P. Bottinger,Donald W. Bowden,Matthew J. Bown,Matthew J. Bown,Jennifer A. Brody,Jai G. Broome,Noël P. Burtt,Brian E. Cade,Brian E. Cade,Federico Centeno-Cruz,Edmund Chan,Yi-Cheng Chang,Yii-Der Ida Chen,Ching-Yu Cheng,Won Jung Choi,Rajiv Chowdhury,Cecilia Contreras-Cubas,Emilio J. Cordova,Adolfo Correa,L. Adrienne Cupples,L. Adrienne Cupples,Joanne E. Curran,John Danesh,John Danesh,Paul S. de Vries,Ralph A. DeFronzo,Harsha Doddapaneni,Ravindranath Duggirala,Susan K. Dutcher,Patrick T. Ellinor,Patrick T. Ellinor,Leslie S. Emery,Jose C. Florez,Myriam Fornage,Barry I. Freedman,Valentin Fuster,Valentin Fuster,Ma. Eugenia Garay-Sevilla,Humberto García-Ortiz,Soren Germer,Richard A. Gibbs,Richard A. Gibbs,Christian Gieger,Benjamin Glaser,Clicerio Gonzalez,María Elena González-Villalpando,Mariaelisa Graff,Sarah E. Graham,Niels Grarup,Leif Groop,Leif Groop,Xiuqing Guo,Namrata Gupta,Sohee Han,Craig L. Hanis,Torben Hansen,Torben Hansen,Jiang He,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Yi-Jen Hung,Mi Yeong Hwang,Marguerite R. Irvin,Sergio A. Islas-Andrade,Gail P. Jarvik,Hyun Min Kang,Sharon L.R. Kardia,Tanika N. Kelly,Eimear E. Kenny,Alyna T. Khan,Bong-Jo Kim,Ryan W. Kim,Young-Jin Kim,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Charles Kooperberg,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Leslie A. Lange,Jiwon Lee,Juyoung Lee,Seonwook Lee,Donna M. Lehman,Rozenn N. Lemaitre,Allan Linneberg,Allan Linneberg,Jianjun Liu,Jianjun Liu,Ruth J. F. Loos,Steven A. Lubitz,Steven A. Lubitz,Valeriya Lyssenko,Valeriya Lyssenko,Ronald C.W. Ma,Lisa W. Martin,Angélica Martínez-Hernández,Rasika A. Mathias,Stephen T. McGarvey,Ruth McPherson,James B. Meigs,James B. Meigs,Thomas Meitinger,Olle Melander,Elvia Mendoza-Caamal,Ginger A. Metcalf,Xuenan Mi,Karen L. Mohlke,May E. Montasser,Jee-Young Moon,Hortensia Moreno-Macías,Alanna C. Morrison,Donna M. Muzny,Sarah C. Nelson,Peter M. Nilsson,Jeffrey R. O'Connell,Marju Orho-Melander,Lorena Orozco,Colin N. A. Palmer,Nicholette D. Palmer,Cheol Joo Park,Kyong Soo Park,Kyong Soo Park,Kyong Soo Park,Oluf Pedersen,Juan M. Peralta,Patricia A. Peyser,Wendy S. Post,Michael Preuss,Bruce M. Psaty,Qibin Qi,D. C. Rao,Susan Redline,Susan Redline,Alexander P. Reiner,Cristina Revilla-Monsalve,Stephen S. Rich,Nilesh J. Samani,Nilesh J. Samani,Heribert Schunkert,Claudia Schurmann,Claudia Schurmann,Daekwan Seo,Jeong-Sun Seo,Xueling Sim,Xueling Sim,Robert Sladek,Kerrin S. Small,Wing-Yee So,Adrienne M. Stilp,E. Shyong Tai,Claudia H. T. Tam,Kent D. Taylor,Yik Ying Teo,Farook Thameem,Brian Tomlinson,Michael Y. Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Teresa Tusié-Luna,Rob M. van Dam,Rob M. van Dam,Rob M. van Dam,Ramachandran S. Vasan,Ramachandran S. Vasan,Karine A. Viaud Martinez,Fei Fei Wang,Xuzhi Wang,Hugh Watkins,Daniel E. Weeks,James G. Wilson,Daniel R. Witte,Daniel R. Witte,Tien Yin Wong,Lisa R. Yanek,Amp-T D-Genes,Sekar Kathiresan,Daniel J. Rader,Jerome I. Rotter,Michael Boehnke,Mark I. McCarthy,Cristen J. Willer,Pradeep Natarajan,Jason Flannick,Jason Flannick,Jason Flannick,Amit Khera,Amit Khera,Gina M. Peloso +225 more
TL;DR: In this article, gene-based association testing of blood lipid levels with rare (minor allele frequency 170,000 individuals from multiple ancestries: 97,493 European, 30,025 South Asian, 16,507 African, 16.440 Hispanic/Latino, 10,420 East Asian, and 1,182 Samoan was performed.
Journal ArticleDOI
Pharmacogenetic Perturbations in Humans as a Tool to Generate Mechanistic Insight
TL;DR: Although GWAS constitute a powerful approach to rapidly and systematically uncover associations that may open new windows into T2D pathophysiology, they do not circumvent the need to refine the associated loci to find the precise “causal” DNA sequences—causal in the sense that altering these sequences would eliminate the clinical phenotype.
Posted ContentDOI
Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification
Lagou,Lagou,Lagou,Longda Jiang,Longda Jiang,Anna Ulrich,L Zudina,González Ksg,Balkhiyarova Z,Alessia Faggian,Alessia Faggian,Chen S,Petar Todorov,Sodbo Zh Sharapov,Alessia David,Letizia Marullo,Reedik Mägi,Roxana Maria Rujan,Emma Ahlqvist,Gudmar Thorleifsson,He Gao,Evangelos Evangelou,Evangelos Evangelou,Beben Benyamin,Robert A. Scott,Aaron Isaacs,Aaron Isaacs,Jing Hua Zhao,Sara M. Willems,Toby Johnson,C Gieger,H Grallert,Christine Meisinger,Martina Müller-Nurasyid,Rona J. Strawbridge,Anuj Goel,D Rybin,E Albrecht,Anne U. Jackson,Heather M. Stringham,Corrêa Ir,Eric F,Steinthorsdottir,Andre G. Uitterlinden,Patricia B. Munroe,Morris J. Brown,Julian S,Oddgeir L. Holmen,Barbara Thorand,Kristian Hveem,Tom Wilsgaard,Karen L. Mohlke,Wolfgang Kratzer,Mark H,Wolfgang Koenig,Wolfgang Koenig,Bernhard O. Boehm,Tan Tm,Tomas A,Salem,Inês Barroso,J. Tuomilehto,J. Tuomilehto,J. Tuomilehto,Boehnke M,Jose C. Florez,Jose C. Florez,Anders Hamsten,Anders Hamsten,Hugh Watkins,Inger Njølstad,Heinz Erich Wichmann,Mark J. Caulfield,Kay-Tee Khaw,van Duijn C,van Duijn C,Amy Hofman,Nicholas J. Wareham,Claudia Langenberg,John Whitfield,N. G. Martin,Grant W. Montgomery,Grant W. Montgomery,Chiara Scapoli,Ioanna Tzoulaki,Ioanna Tzoulaki,Paul Elliott,Paul Elliott,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Evan L. Brittain,Mark I. McCarthy,Mark I. McCarthy,Philippe Froguel,Philippe Froguel,Patrick M. Sexton,Denise Wootten,Leif Groop,Leif Groop,Josée Dupuis,James B. Meigs,James B. Meigs,Giuseppe Deganutti,Ayse Demirkan,Ayse Demirkan,Tune H. Pers,Christopher A. Reynolds,Christopher A. Reynolds,Yurii S. Aulchenko,Marika Kaakinen,Marika Kaakinen,Jones B,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko +116 more
TL;DR: In this paper, a meta-analysis of random glucose measurements in 493,036 individuals without diabetes of diverse ethnicities was conducted to identify 128 associated loci represented by 162 distinct signals, including 14 with sex-dimorphic effects, 9 discovered through trans-ethnic analysis and 70 novel signals for glycaemic traits.
Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals
Ching-Ti Liu,Jordi Merino,Denis Rybin,Daniel DiCorpo,Kelly S. Benke,Jennifer L. Bragg-Gresham,Mickaël Canouil,Tanguy Corre,Harald Grallert,Aaron Isaacs,Zoltán Kutalik,Jari Lahti,Letizia Marullo,Carola Marzi,Laura J. Rasmussen-Torvik,Ghislain Rocheleau,Rico Rueedi,Chiara Scapoli,Niek Verweij,Nicole Vogelzangs,Sara M. Willems,Loic Yengo,Stephan J. L. Bakker,John Beilby,Jennie Hui,Eero Kajantie,Martina Mueller-Nurasyid,Wolfgang Rathman,Beverley Balkau,Sven Bergmann,Johan G. Eriksson,Jose C. Florez,Philippe Froguel,Tamara B. Harris,Joseph Hung,Alan James,Maryam Kavousi,Iva Miljkovic,Arthur W. Musk,Lyle J. Palmer,Annette Peters,Ronan Roussel,Pim van der Harst,Cornelia M. van Duijn,Peter Vollenweider,Inês Barroso,Inga Prokopenko,Josée Dupuis,James B. Meigs,Nabila Bouatia-Naji +49 more
TL;DR: A genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts suggests that genetic effects on fasting glucose change over time are likely to be small.
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Valérie Turcot,Yingchang Lu,Heather M. Highland,Claudia Schurmann,Anne E. Justice,Rebecca S. Fine,Jonathan P. Bradfield,Tõnu Esko,Ayush Giri,Mariaelisa Graff,Xiuqing Guo,Audrey E. Hendricks,Tugce Karaderi,Adelheid Lempradl,Adam E. Locke,Anubha Mahajan,Eirini Marouli,Suthesh Sivapalaratnam,Kristin L. Young,Tamuno Alfred,Mary F. Feitosa,Nicholas G. D. Masca,Alisa K. Manning,Carolina Medina-Gomez,Poorva Mudgal,Maggie C.Y. Ng,Alexander P. Reiner,Sailaja Vedantam,Sara M. Willems,Thomas W. Winkler,Gonçalo R. Abecasis,Katja K.H. Aben,Dewan S. Alam,Sameer E. Al-Harthi,Matthew A. Allison,Philippe Amouyel,Folkert W. Asselbergs,Paul L. Auer,Beverley Balkau,Lia E. Bang,Inês Barroso,Lisa Bastarache,Marianne Benn,Sven Bergmann,Lawrence F. Bielak,Matthias Blueher,Michael Boehnke,Heiner Boeing,Eric Boerwinkle,Carsten A. Boeger,Jette Bork-Jensen,Michiel L. Bots,Erwin P. Bottinger,Donald W. Bowden,Ivan Brandslund,Gerome Breen,Murray H. Brilliant,Linda Broer,Marco Brumat,Amber A. Burt,Adam S. Butterworth,Peter T. Campbell,Stefania Cappellani,David J. Carey,Eulalia Catamo,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Yii-Der Ida Chen,Rajiv Chowdhury,Cramer Christensen,Audrey Y. Chu,Massimiliano Cocca,Francis S. Collins,James P. Cook,Janie Corley,Jordi Corominas Galbany,Amanda J. Cox,David S. Crosslin,Gabriel Cuellar-Partida,Angela D'Eustacchio,John Danesh,Gail Davies,Paul I. W. de Bakker,Mark C. H. Groot,Renée de Mutsert,Ian J. Deary,George Dedoussis,Ellen W. Demerath,Martin den Heijer,Anneke I den Hollander,Hester M. den Ruijter,Joe Dennis,Josh C. Denny,Emanuele Di Angelantonio,Fotios Drenos,Mengmeng Du,Marie-Pierre Dubé,Alison M. Dunning,Douglas F. Easton,Todd L. Edwards,David Ellinghaus,Patrick T. Ellinor,Paul Elliott,Evangelos Evangelou,Aliki-Eleni Farmaki,I. Sadaf Farooqi,Jessica D. Faul,Sascha Fauser,Shuang Feng,Ele Ferrannini,Jean Ferrières,Jose C. Florez,Ian Ford,Myriam Fornage,Oscar H. Franco,Andre Franke,Paul W. Franks,Nele Friedrich,Ruth Frikke-Schmidt,Tessel E. Galesloot,Wei Gan,Ilaria Gandin,Paolo Gasparini,Jane Gibson,Vilmantas Giedraitis,Anette P. Gjesing,Penny Gordon-Larsen,Mathias Gorski,Hans-Joergen Grabe,Struan F.A. Grant,Niels Grarup,Helen Griffiths,Megan L. Grove,Vilmundur Gudnason,Stefan Gustafsson,Jeffrey Haessler,Hakon Hakonarson,Anke R. Hammerschlag,Torben Hansen,Kathleen Mullan Harris,Tamara B. Harris,Andrew T. Hattersley,Christian Theil Have,Caroline Hayward,Liang He,Nancy L. Heard-Costa,Andrew Heath,Iris M. Heid,Øyvind Helgeland,Jussi Hernesniemi,Alex W. Hewitt,Oddgeir L. Holmen,G. Kees Hovingh,Joanna M. M. Howson,Yao Hu,Paul L. Huang,Jennifer E. Huffman,M. Arfan Ikram,Erik Ingelsson,Anne U. Jackson,Jan-Håkan Jansson,Gail P. Jarvik,Gorm B. Jensen,Yucheng Jia,Stefan Johansson,Marit E. Jørgensen,Torben Jørgensen,J. Wouter Jukema,Bratati Kahali,René S. Kahn,Mika Kähönen,Pia R. Kamstrup,Stavroula Kanoni,Jaakko Kaprio,Maria Karaleftheri,Sharon L.R. Kardia,Fredrik Karpe,Sekar Kathiresan,Frank Kee,Lambertus A. Kiemeney,Eric Kim,Hidetoshi Kitajima,Pirjo Komulainen,Jaspal S. Kooner,Charles Kooperberg,Tellervo Korhonen,Peter Kovacs,Helena Kuivaniemi,Zoltán Kutalik,Kari Kuulasmaa,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,David Lamparter,Ethan M. Lange,Leslie A. Lange,Claudia Langenberg,Eric B. Larson,Nanette R. Lee,Terho Lehtimäki,Cora E. Lewis,Huaixing Li,Jin Li,Ruifang Li-Gao,Honghuang Lin,Keng-Hung Lin,Li-An Lin,Xu Lin,Lars Lind,Jaana Lindström,Allan Linneberg,Ching-Ti Liu,Dajiang J. Liu,Yongmei Liu,Ken S. Lo,Artitaya Lophatananon,Andrew J. Lotery,Anu Loukola,Jian'an Luan,Steven A. Lubitz,Leo-Pekka Lyytikäinen,Satu Männistö,Gaëlle Marenne,Angela L. Mazul,Mark I. McCarthy,Roberta McKean-Cowdin,Sarah E. Medland,Karina Meidtner,Lili Milani,Vanisha Mistry,Paul Mitchell,Karen L. Mohlke,Leena Moilanen,Marie Moitry,Grant W. Montgomery,Dennis O. Mook-Kanamori,Carmel Moore,Trevor A. Mori,Andrew D. Morris,Andrew P. Morris,Martina Mueller-Nurasyid,Patricia B. Munroe,Mike A. Nalls,Narisu Narisu,Christopher P. Nelson,Matt Neville,Sune F. Nielsen,Kjell Nikus,Pål R. Njølstad,Børge G. Nordestgaard,Dale R. Nyholt,Jeffrey R. O'Connel,Michelle L. O'Donoghue,Loes M. Olde Loohuis,Roel A. Ophoff,Katharine R. Owen,Chris J. Packard,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Gerard Pasterkamp,Aniruddh P. Patel,Alison Pattie,Oluf Pedersen,Peggy L. Peissig,Gina M. Peloso,Craig E. Pennell,Markus Perola,James A. Perry,John R. B. Perry,Tune H. Pers,Thomas N. Person,Annette Peters,Eva Rabing Brix Petersen,Patricia A. Peyser,Ailith Pirie,Ozren Polasek,Tinca J. C. Polderman,Hannu Puolijoki,Olli T. Raitakari,Asif Rasheed,Rainer Rauramaa,Dermot F. Reilly,Frida Renström,Myriam Rheinberger,Paul M. Ridker,John D. Rioux,Manuel A. Rivas,David J. Roberts,Neil R. Robertson,Antonietta Robino,Olov Rolandsson,Igor Rudan,Katherine S. Ruth,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Yadav Sapkota,Naveed Sattar,Robert E. Schoen,Pamela J. Schreiner,Matthias B. Schulze,Robert A. Scott,Marcelo P. Segura-Lepe,Svati H. Shah,Wayne Huey-Herng Sheu,Xueling Sim,Andrew J. Slater,Kerrin S. Small,Albert V. Smith,Lorraine Southam,Tim D. Spector,Elizabeth K. Speliotes,John M. Starr,Kari Stefansson,Valgerdur Steinthorsdottir,Kathleen Stirrups,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Liang Sun,Praveen Surendran,Amy J. Swift,Hayato Tada,Katherine E. Tansey,Jean-Claude Tardif,Kent D. Taylor,Alexander Teumer,Deborah J. Thompson,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Betina H. Thuesen,Anke Toenjes,Gerard Tromp,Stella Trompet,Emmanouil Tsafantakis,Jaakko Tuomilehto,Anne Tybjærg-Hansen,Jonathan Tyrer,Rudolf Uher,André G. Uitterlinden,Matti Uusitupa,Sander W. van der Laan,Cornelia M. van Duijn,Nienke van Leeuwen,Jessica van Setten,Mauno Vanhala,Anette Varbo,Tibor V. Varga,Rohit Varma,Digna R. Velez Edwards,Sita H. Vermeulen,Giovanni Veronesi,Henrik Vestergaard,Veronique Vitart,Thomas F. Vogt,Uwe Voelker,Dragana Vuckovic,Lynne E. Wagenknecht,Mark Walker,Lars Wallentin,Feijie Wang,Carol A. Wang,Shuai Wang,Yiqin Wang,Erin B. Ware,Nicholas J. Wareham,Helen R. Warren,Dawn M. Waterworth,Jennifer Wessel,Harvey D. White,Cristen J. Willer,James G. Wilson,Daniel R. Witte,Andrew R. Wood,Ying Wu,Hanieh Yaghootkar,Jie Yao,Pang Yao,Laura M. Yerges-Armstrong,Robin Young,Eleftheria Zeggini,Xiaowei Zhan,Weihua Zhang,Jing Hua Zhao,Wei Zhao,Wei Zhou,Krina T. Zondervan,Jerome I. Rotter,John Andrew Pospisilik,Fernando Rivadeneira,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Guillaume Lettre,Kari E. North,Cecilia M. Lindgren,Joel N. Hirschhorn,Ruth J. F. Loos +399 more
TL;DR: Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.