J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
The C Allele of ATM rs11212617 Does Not Associate With Metformin Response in the Diabetes Prevention Program
Jose C. Florez,Kathleen A. Jablonski,Andrew W. Taylor,Andrew W. Taylor,Kieren J. Mather,Edward S. Horton,Edward S. Horton,Neil H. White,Elizabeth Barrett-Connor,William C. Knowler,Alan R. Shuldiner,Toni I. Pollin +11 more
TL;DR: The reported association of rs11212617 with metformin response was not confirmed for diabetes prevention or for effects on relevant physiologic parameters in the DPP.
Journal ArticleDOI
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Vasiliki Lagou,Vasiliki Lagou,Reedik Mägi,Hottenga J-J.,Hottenga J-J.,H Grallert,Perry Jrb.,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Letizia Marullo,D Rybin,Rick Jansen,Josine L. Min,Antigone S. Dimas,Anna Ulrich,L Zudina,Jesper R. Gådin,Longda Jiang,Alessia Faggian,Amélie Bonnefond,Amélie Bonnefond,Amélie Bonnefond,João Fadista,Maria G. Stathopoulou,Aaron Isaacs,Aaron Isaacs,Sara M. Willems,Pau Navarro,Tomohiro Tanaka,Anne U. Jackson,May E. Montasser,Jeffery R. O'Connell,L.F. Bielak,Rebecca J. Webster,Richa Saxena,Jeanette M. Stafford,Beate St Pourcain,N J Timpson,Perttu Salo,Shin S-Y.,Najaf Amin,Albert V. Smith,Guo Li,Niek Verweij,Anuj Goel,Ian Ford,Johnson Pcd.,Johnson Pcd.,Toby Johnson,Karen Kapur,Gudmar Thorleifsson,Rona J. Strawbridge,Rona J. Strawbridge,Rona J. Strawbridge,Laura J. Rasmussen-Torvik,Tõnu Esko,Evelin Mihailov,Tove Fall,Ross M. Fraser,Anubha Mahajan,Anubha Mahajan,Stavroula Kanoni,Stavroula Kanoni,Vilmantas Giedraitis,Marcus E. Kleber,Günther Silbernagel,Joanne M. Meyer,Martina Müller-Nurasyid,Andrea Ganna,Andrea Ganna,Sarin A-P.,Sarin A-P.,Loic Yengo,Loic Yengo,Loic Yengo,Dmitry Shungin,Jian'an Luan,Momoko Horikoshi,Ping An,Serena Sanna,Yvonne Boettcher,Nigel W. Rayner,Nigel W. Rayner,Ilja M. Nolte,Tatijana Zemunik,Erik P A Van Iperen,Peter Kovacs,Nicholas D. Hastie,Sarah H. Wild,Stela McLachlan,Susan Campbell,Ozren Polasek,Olga D. Carlson,Josephine M. Egan,Wieland Kiess,Gonneke Willemsen,Johanna Kuusisto,Markku Laakso,Maria Dimitriou,Andrew A. Hicks,R. Rauramaa,Stefania Bandinelli,Barbara Thorand,Yongmei Liu,Iva Miljkovic,Lars Lind,Alex S. F. Doney,Markus Perola,Markus Perola,Markus Perola,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Meena Kumari,Amanda J. Bennett,Christopher J. Groves,Christian Herder,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Leena Kinnunen,Ulf de Faire,Bakker Sjl.,M. I. J. Uusitupa,Palmer Cna.,Joop Jukema,Naveed Sattar,Anneli Pouta,Anneli Pouta,Harold Snieder,Eric Boerwinkle,James S. Pankow,Patrik K. E. Magnusson,Ulrika Krus,Chiara Scapoli,de Geus Ejcn.,de Geus Ejcn.,M Blüher,M Blüher,Wolffenbuttel Bhr.,M. A. Province,Gonçalo R. Abecasis,James B. Meigs,James B. Meigs,G K Hovingh,Jaana Lindström,James F. Wilson,James F. Wilson,Alan F. Wright,George Dedoussis,Stefan R Bornstein,Schwarz Peh.,Anke Tönjes,Winkelmann Br,Bernhard O. Boehm,Winfried März,Winfried März,A. Metspalu,Jackie F. Price,Panagiotis Deloukas,Panagiotis Deloukas,Panagiotis Deloukas,A. Körner,A. Körner,Timo A. Lakka,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,T. Saaristo,Richard N. Bergman,Jaakko Tuomilehto,Nicholas J. Wareham,Claudia Langenberg,Satu Männistö,Paul W. Franks,Paul W. Franks,Caroline Hayward,Veronique Vitart,Jaakko Kaprio,Sophie Visvikis-Siest,B. Balkau,B. Balkau,David Altshuler,David Altshuler,Igor Rudan,Michael Stumvoll,Harry Campbell,C M van Duijn,C Gieger,Thomas Illig,Luigi Ferrucci,Nancy L. Pedersen,Peter P. Pramstaller,Boehnke M,Timothy M. Frayling,Alan R. Shuldiner,Alan R. Shuldiner,Patricia A. Peyser,Kardia Slr.,Lyle J. Palmer,B.W.J.H. Penninx,Pierre Meneton,T.B. Harris,Gerjan Navis,Harst Pvd.,George Davey Smith,Nita G. Forouhi,Loos Rjf.,Loos Rjf.,Veikko Salomaa,Nicole Soranzo,Dorret I. Boomsma,Leif Groop,Leif Groop,Tiinamaija Tuomi,Albert Hofman,Albert Hofman,Patricia B. Munroe,Vilmundur Gudnason,David S. Siscovick,Hugh Watkins,C. Lecoeur,C. Lecoeur,Peter Vollenweider,Anders Franco-Cereceda,Per Eriksson,Jarvelin M-R.,Jarvelin M-R.,Kari Stefansson,Kari Stefansson,Anders Hamsten,Anders Hamsten,George Nicholson,F Karpe,F Karpe,Emmanouil T. Dermitzakis,Cecilia M. Lindgren,Mark I. McCarthy,Philippe Froguel,Philippe Froguel,Philippe Froguel,Marika Kaakinen,Marika Kaakinen,Valeriya Lyssenko,Valeriya Lyssenko,Richard M. Watanabe,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Jose C. Florez,Josée Dupuis,Inês Barroso,Inês Barroso,Inês Barroso,Andrew P. Morris,Inga Prokopenko +254 more
TL;DR: In this paper, the authors assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association study meta-analyses.
Journal ArticleDOI
Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.
Christina M Astley,Christina M Astley,Christina M Astley,Jennifer N. Todd,Rany M. Salem,Sailaja Vedantam,Sailaja Vedantam,Cara B. Ebbeling,Cara B. Ebbeling,Paul L. Huang,David S. Ludwig,David S. Ludwig,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Jose C. Florez,Jose C. Florez +16 more
TL;DR: Mendelian randomization analyses provide evidence for a causal relationship of glucose-stimulated insulin secretion on body weight, consistent with the carbohydrate-insulin model of obesity.
Journal ArticleDOI
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program
Jose C. Florez,Kathleen A. Jablonski,Jarred B. McAteer,Jarred B. McAteer,Manjinder S. Sandhu,Nicholas J. Wareham,Inês Barroso,Paul W. Franks,David Altshuler,W. C. Knowler +9 more
TL;DR: The previously reported protective effect of select WFS1 alleles may be magnified by a lifestyle intervention, and these variants appear to confer an improvement in beta cell function.
Journal ArticleDOI
An exome array study of the plasma metabolome
Eugene P. Rhee,Qiong Yang,Bing Yu,Xuan Liu,Susan Cheng,Amy Deik,Kerry A. Pierce,Kevin Bullock,Jennifer E. Ho,Daniel Levy,Jose C. Florez,S. Kathiresan,Martin G. Larson,Martin G. Larson,Ramachandran S. Vasan,Ramachandran S. Vasan,Clary B. Clish,Thomas J. Wang,Eric Boerwinkle,Eric Boerwinkle,Christopher J. O'Donnell,Robert E. Gerszten +21 more
TL;DR: This work analyzes the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study and replication in 1,528 participants of the Atherosclerosis Risk in Communities Study to provide a more complete picture of the genetic architecture of the plasma metabolome.