J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes
Josep M. Mercader,Josep M. Mercader,Josep M. Mercader,Rachel G. Liao,Avery Davis Bell,Avery Davis Bell,Zachary Dymek,Karol Estrada,Karol Estrada,Taru Tukiainen,Taru Tukiainen,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Hortensia Moreno-Macías,Kathleen A. Jablonski,Robert L. Hanson,Geoffrey A. Walford,Geoffrey A. Walford,Ignasi Moran,Ling Chen,Ling Chen,Vineeta Agarwala,María Luisa Ordóñez-Sánchez,Rosario Rodríguez-Guillén,Maribel Rodriguez-Torres,Yayoi Segura-Kato,Humberto García-Ortiz,Federico Centeno-Cruz,Francisco Barajas-Olmos,Lizz Caulkins,Sobha Puppala,Pierre Fontanillas,Amy L. Williams,Sílvia Bonàs-Guarch,Christopher Hartl,Stephan Ripke,Stephan Ripke,Stephan Ripke,Katherine Tooley,Katherine Tooley,Jacqueline M. Lane,Jacqueline M. Lane,Carlos Zerrweck,Angélica Martínez-Hernández,Emilio J. Cordova,Elvia Mendoza-Caamal,Cecilia Contreras-Cubas,María Elena González-Villalpando,Ivette Cruz-Bautista,Liliana Muñoz-Hernandez,Donaji V. Gómez-Velasco,Ulises Alvirde,Brian E. Henderson,Lynne R. Wilkens,Loic Le Marchand,Olimpia Arellano-Campos,Laura Riba,Maegan Harden,Broad Genomics Platform,Stacey Gabriel,Hanna E. Abboud,Maria L. Cortes,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Xavier Soberón,Joanne E. Curran,Christopher P. Jenkinson,Ralph A. DeFronzo,Donna M. Lehman,Craig L. Hanis,Graeme I. Bell,Michael Boehnke,John Blangero,Ravindranath Duggirala,Richa Saxena,Richa Saxena,Daniel G. MacArthur,Daniel G. MacArthur,Jorge Ferrer,Jorge Ferrer,Steven A. McCarroll,Steven A. McCarroll,David Torrents,David Torrents,William C. Knowler,Leslie J. Baier,Noël P. Burtt,Clicerio González-Villalpando,Christopher A. Haiman,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna,Jason Flannick,Jason Flannick,Suzanne B.R. Jacobs,Suzanne B.R. Jacobs,Lorena Orozco,David Altshuler,Jose C. Florez,Jose C. Florez +98 more
TL;DR: It is suggested that reducing IGF2 isoform 2 expression in relevant tissues has potential as a new therapeutic strategy for T2D, even beyond the Latin American population, with no major adverse effects on health or reproduction.
Journal ArticleDOI
Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.
Kieren J. Mather,Catherine Kim,Costas A. Christophi,Vanita R. Aroda,William C. Knowler,S. E. Edelstein,Jose C. Florez,Jose C. Florez,Fernand Labrie,Steven E. Kahn,Ronald B. Goldberg,Elizabeth Barrett-Connor +11 more
TL;DR: In this paper, a secondary analysis of a multicenter randomized clinical trial involving 27 U.S. academic institutions was performed to evaluate the relationship of steroid sex hormones, SHBG and SHBG single-nucleotide polymorphisms (SNPs) with diabetes risk factors and with progression to diabetes in the Diabetes Prevention Program (DPP).
Journal ArticleDOI
Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People
Jose C. Florez,Christina M. Agapakis,Noël P. Burtt,Maria Sun,Peter Almgren,Lennart Råstam,Tiinamaija Tuomi,Daniel Gaudet,Thomas J. Hudson,Mark J. Daly,Kristin G. Ardlie,Joel N. Hirschhorn,Leif Groop,David Altshuler +13 more
TL;DR: No statistically significant evidence of association was observed between PTPN1 SNPs or common haplotypes with type 2 diabetes or with diabetic phenotypes.
Journal ArticleDOI
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Alisa K. Manning,Alisa K. Manning,Heather M. Highland,Heather M. Highland,Jessica A. Gasser,Xueling Sim,Taru Tukiainen,Taru Tukiainen,Pierre Fontanillas,Niels Grarup,Manuel A. Rivas,Anubha Mahajan,Adam E. Locke,Pablo Cingolani,Tune H. Pers,Ana Viñuela,Ana Viñuela,Andrew A. Brown,Andrew A. Brown,Ying Wu,Jason Flannick,Jason Flannick,Christian Fuchsberger,Eric R. Gamazon,Kyle J. Gaulton,Kyle J. Gaulton,Hae Kyung Im,Tanya M. Teslovich,Thomas W. Blackwell,Jette Bork-Jensen,Noël P. Burtt,Yuhui Chen,Todd Green,Christopher Hartl,Hyun Min Kang,Ashok Kumar,Ashok Kumar,Claes Ladenvall,Clement Ma,Loukas Moutsianas,Richard D. Pearson,John R. B. Perry,John R. B. Perry,John R. B. Perry,N. William Rayner,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Laura J. Scott,Martijn van de Bunt,Martijn van de Bunt,Johan G. Eriksson,Antti Jula,Seppo Koskinen,Terho Lehtimäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Suzanne B.R. Jacobs,Jennifer Wessel,Audrey Y. Chu,Robert A. Scott,Mark O. Goodarzi,Christine Blancher,Gemma Buck,David Buck,Peter S. Chines,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Joseph Trakalo,Eric Banks,Jason Carey,Mauricio O. Carneiro,Mark A. DePristo,Yossi Farjoun,Timothy Fennell,Jacqueline I. Goldstein,Jacqueline I. Goldstein,George B. Grant,Martin Hrabé de Angelis,Jared Maguire,Benjamin M. Neale,Benjamin M. Neale,Ryan Poplin,Shaun Purcell,Shaun Purcell,Shaun Purcell,Thomas Schwarzmayr,Khalid Shakir,Joshua D. Smith,Tim M. Strom,Thomas Wieland,Jaana Lindström,Ivan Brandslund,Cramer Christensen,Gabriela L. Surdulescu,Timo A. Lakka,Alex S. F. Doney,Peter M. Nilsson,Nicholas J. Wareham,Claudia Langenberg,Tibor V. Varga,Paul W. Franks,Paul W. Franks,Paul W. Franks,Olov Rolandsson,Anders Rosengren,Vidya S. Farook,Farook Thameem,Sobha Puppala,Satish Kumar,Donna M. Lehman,Christopher P. Jenkinson,Joanne E. Curran,Daniel E. Hale,Sharon P. Fowler,Rector Arya,Ralph A. DeFronzo,Hanna E. Abboud,Ann-Christine Syvänen,Pamela J. Hicks,Nicholette D. Palmer,Maggie C.Y. Ng,Donald W. Bowden,Barry I. Freedman,Tõnu Esko,Reedik Mägi,Lili Milani,Evelin Mihailov,Andres Metspalu,Narisu Narisu,Leena Kinnunen,Lori L. Bonnycastle,Amy J. Swift,Dorota Pasko,Andrew R. Wood,João Fadista,Toni I. Pollin,Nir Barzilai,Gil Atzmon,Benjamin Glaser,Barbara Thorand,Konstantin Strauch,Annette Peters,Michael Roden,Martina Müller-Nurasyid,Liming Liang,Jennifer Kriebel,Thomas Illig,Harald Grallert,Christian Gieger,Christa Meisinger,Lars Lannfelt,Solomon K. Musani,Michael Griswold,Herman A. Taylor,Gregory A Wilson,Adolfo Correa,Heikki Oksa,William R. Scott,Uzma Afzal,Sian-Tsung Tan,Marie Loh,Marie Loh,Marie Loh,John C. Chambers,John C. Chambers,John C. Chambers,Jobanpreet Sehmi,Jaspal S. Kooner,Benjamin Lehne,Yoon Shin Cho,Jong-Young Lee,Bok-Ghee Han,Annemari Käräjämäki,Qibin Qi,Qibin Qi,Lu Qi,Lu Qi,Jinyan Huang,Frank B. Hu,Olle Melander,Marju Orho-Melander,Jennifer E. Below,David Aguilar,Tien Yin Wong,Jianjun Liu,Jianjun Liu,Chiea Chuen Khor,Kee Seng Chia,Wei-Yen Lim,Ching-Yu Cheng,Edmund Chan,E. Shyong Tai,Tin Aung,Allan Linneberg,Allan Linneberg,Bo Isomaa,Thomas Meitinger,Tiinamaija Tuomi,Liisa Hakaste,Jasmina Kravic,Marit E. Jørgensen,Torsten Lauritzen,Panos Deloukas,Kathleen Stirrups,Kathleen Stirrups,Katharine R. Owen,Andrew Farmer,Timothy M. Frayling,Stephen O'Rahilly,Mark Walker,Jonathan C. Levy,Dylan Hodgkiss,Andrew T. Hattersley,Teemu Kuulasmaa,Alena Stančáková,Inês Barroso,Inês Barroso,Dwaipayan Bharadwaj,Juliana C.N. Chan,Giriraj R. Chandak,Mark J. Daly,Peter Donnelly,Peter Donnelly,Shah Ebrahim,Paul Elliott,Tasha E. Fingerlin,Philippe Froguel,Cheng Hu,Weiping Jia,Ronald C.W. Ma,Gilean McVean,Taesung Park,Dorairaj Prabhakaran,Manjinder S. Sandhu,Manjinder S. Sandhu,James Scott,Robert Sladek,Nikhil Tandon,Yik Ying Teo,Eleftheria Zeggini,Richard M. Watanabe,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Y. Antero Kesäniemi,Matti Uusitupa,Tim D. Spector,Veikko Salomaa,Rainer Rauramaa,Colin N. A. Palmer,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Andrew D. Morris,Richard N. Bergman,Francis S. Collins,Lars Lind,Erik Ingelsson,Jaakko Tuomilehto,Fredrik Karpe,Leif Groop,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Oluf Pedersen,Johanna Kuusisto,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Mark Seielstad,Mark Seielstad,James G. Wilson,Josée Dupuis,Samuli Ripatti,Samuli Ripatti,Craig L. Hanis,Jose C. Florez,Karen L. Mohlke,James B. Meigs,James B. Meigs,Markku Laakso,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,David Altshuler,Mark I. McCarthy,Mark I. McCarthy,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren +312 more
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.
Journal ArticleDOI
Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth.
Dana Dabelea,L. M. Dolan,Ralph B. D'Agostino,Alicia M. Hernandez,Jarred B. McAteer,Jarred B. McAteer,Richard F. Hamman,Elizabeth J. Mayer-Davis,Santica M. Marcovina,Jean M. Lawrence,Catherine Pihoker,Jose C. Florez,Jose C. Florez +12 more
TL;DR: TCF7L2 variation is associated with an increased risk of early-onset type 2 diabetes among AA youth, and the association appears to be stronger in AA than NHW youth, which suggests potential different contributions of genetic and environmental factors to early-ONSet type 1 diabetes by race.