Jose C. Florez

TL;DR: In this article , the authors compared the heritability of crude averages with empirical Bayes weighted averages for 302 correlated dietary variables from multiple 24-hour recall questionnaires in 177 K individuals in UK Biobank and found that the more heritable versions of each dietary variable lead to stronger underlying statistical associations with specific genetic loci.

TL;DR: The application of agnostic gene discovery efforts has facilitated the identification of mutations in genes newly linked to diseases such as congenital forms of diabetes, monogenic diabetes, and syndromes of insulin resistance, lending new insights regarding pathophysiological processes, and providing human null models of more common complex forms of disease.

TL;DR: How genomic discovery has contributed to unraveling the heterogeneity in T2D is summarized, relevant discoveries in the pharmacogenetics of five commonly prescribed glucose-lowering agents are reviewed, and evidence supporting how pharmacogenetic principles can be leveraged to advance precision medicine is presented.

TL;DR: This paper conducted the largest GWAS meta-analysis using a recessive model for type 2 diabetes and identified 51 loci associated with Type 2 diabetes, including five variants with recessive effects undetected by prior additive analyses.

TL;DR: In this paper , a semi-automated Bayesian non-negative matrix factorization (bNMF) pipeline was used to generate new ancestry-specific clusters in European (EUR, 390 SNVs), East Asian (EAS, 326 SNVs) and African (AFR, 172 SNVs).