J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
Papers
More filters
Journal ArticleDOI
Genetic Architecture of Plasma Alpha‐Aminoadipic Acid Reveals a Relationship With High‐Density Lipoprotein Cholesterol
Mingjian Shi,Chuan Wang,Hao Mei,Marinella Temprosa,Jose C. Florez,Mark Tripputi,Jordi Merino,Loren Lipworth,Xiao-Ou Shu,Robert E. Gerszten,Thomas J. Wang,Joshua A. Beckman,Jorge L. Gamboa,Jonathan D. Mosley,Jane F. Ferguson +14 more
TL;DR: 2‐AAA levels in plasma may be regulated, in part, by common variants in genes involved in mitochondrial and macrophage function, and Elevated plasma 2‐AAA associates with reduced levels of high‐density lipoprotein cholesterol.
Journal ArticleDOI
Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity.
Sara Cromer,Chirag M. Lakhani,Josep M. Mercader,Timothy D. Majarian,Philip H. Schroeder,Joanne B. Cole,Jose C. Florez,Chirag J. Patel,Alisa K. Manning,Sherri-Ann M. Burnett-Bowie,Jordi Merino,Miriam S. Udler +11 more
TL;DR: In this article , the impact of genetic and socioeconomic factors on risk of type 2 diabetes and obesity was quantified using logistic regression models to calculate cross-sectional odds of T2D and obesity using polygenic risk scores and area-level socioeconomic risk (educational attainment) measures.
Posted ContentDOI
Mct11 deficiency alters hepatic glucose metabolism and energy homeostasis
Alina Ainbinder,Liping Zhao,Patricia Glover,Karen Gelinas-Roa,Victor Rusu,Victor Rusu,Alycen Harney,Eitan Hoch,Amy Deik,Kerry A. Pierce,Kevin Bullock,Courtney Dennis,Sarah Jeanfavre,Jesse Krejci,Jinyoung Choi,Anthony N. Hollenberg,Federico Centeno-Cruz,Francisco Barajas-Olmos,Carlos Zerrweck,Lorena Orozco,Clary B. Clish,Eric S. Lander,Eric S. Lander,Jose C. Florez,Suzanne B.R. Jacobs,Suzanne B.R. Jacobs +25 more
TL;DR: This article showed that SLC16A11 expression within the liver is primarily localized to the low oxygen pericentral region, and that T2D risk variants disrupt oxygen-regulated SLC 16A11 gene expression in human hepatocytes.
Journal ArticleDOI
Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182.
Jason L. Vassy,Marie-France Hivert,Bianca Porneala,Marco Dauriz,Jose C. Florez,Josée Dupuis,David S. Siscovick,Myriam Fornage,Laura J. Rasmussen-Torvik,Claude Bouchard,James B. Meigs +10 more
TL;DR: In Table 1 of the above-mentioned article, the ST6GAL1 locus was erroneously mislabeled as ST5GAL2 locus, which is not a valid locus and should not be considered as a locus for drug discovery.
A Large Genome-wide Association Study of Glycated Hemoglobin Identifies Ten Common Variants not Mediated Through BMI
Eleanor Wheeler,Nicole Soranzo,Serena Sanna,C Gieger,Dörte Radke,Josée Dupuis,Elliot S. Stolerman,Nabila Bouatia-Naji,Claudia Langenberg,Inga Prokopenko,Sandhu,Linda Kao,Nicholas J. Wareham,Jose C. Florez,Manuela Uda,Inês Barroso,James B. Meigs,Magic Investigators +17 more