J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Association of Variants in RETN With Plasma Resistin Levels and Diabetes-Related Traits in the Framingham Offspring Study
Marie-France Hivert,Alisa K. Manning,Jarred B. McAteer,Josée Dupuis,Caroline S. Fox,L. Adrienne Cupples,James B. Meigs,Jose C. Florez +7 more
TL;DR: SNPs in the 3′ region of RETN are associated with resistin levels, and one of them is also associated with glucose levels, although replication is needed.
Journal ArticleDOI
Extension of Type 2 Diabetes Genome-Wide Association Scan Results in the Diabetes Prevention Program
Allan F. Moore,Kathleen A. Jablonski,Jarred B. McAteer,Richa Saxena,Toni I. Pollin,Paul W. Franks,Robert L. Hanson,Alan R. Shuldiner,William C. Knowler,David Altshuler,Jose C. Florez +10 more
TL;DR: It is unable to replicate the GWAS findings regarding diabetes risk in the DPP, but did observe genotype associations with differences in baseline insulin secretion at the HHEX locus and a possible pharmacogenetic interaction at CDKNA2/B.
Journal ArticleDOI
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
Viktoria Gusarova,Colm O'Dushlaine,Tanya M. Teslovich,Peter N. Benotti,Tooraj Mirshahi,Omri Gottesman,Cristopher V. Van Hout,Michael F. Murray,Anubha Mahajan,Jonas B. Nielsen,Lars G. Fritsche,Anders Berg Wulff,Daniel F. Gudbjartsson,Marketa Sjögren,Connor A. Emdin,Robert A. Scott,Wen-Jane Lee,Aeron Small,Lydia Coulter Kwee,Om Prakash Dwivedi,Rashmi B. Prasad,Shannon Bruse,Alexander Lopez,John Penn,Anthony Marcketta,Joseph B. Leader,Christopher D. Still,H. Lester Kirchner,Uyenlinh L. Mirshahi,Amr H. Wardeh,Cassandra M. Hartle,Lukas Habegger,Samantha N. Fetterolf,Teresa Tusié-Luna,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Hilma Holm,Valgerdur Steinthorsdottir,Patrick Sulem,Unnur Thorsteinsdottir,Jerome I. Rotter,Lee-Ming Chuang,Scott M. Damrauer,Scott M. Damrauer,David Birtwell,Chad M. Brummett,Amit Khera,Amit Khera,Pradeep Natarajan,Pradeep Natarajan,Marju Orho-Melander,Jason Flannick,Jason Flannick,Luca A. Lotta,Cristen J. Willer,Oddgeir L. Holmen,Marylyn D. Ritchie,David H. Ledbetter,Andrew J. Murphy,Ingrid B. Borecki,Jeffrey G. Reid,John D. Overton,Ola Hansson,Ola Hansson,Leif Groop,Leif Groop,Svati H. Shah,William E. Kraus,Daniel J. Rader,Yii-Der Ida Chen,Kristian Hveem,Kristian Hveem,Nicholas J. Wareham,Sekar Kathiresan,Olle Melander,Kari Stefansson,Børge G. Nordestgaard,Anne Tybjærg-Hansen,Gonçalo R. Abecasis,David Altshuler,Jose C. Florez,Jose C. Florez,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,George D. Yancopoulos,David J. Carey,Alan R. Shuldiner,Aris Baras,Frederick E. Dewey,Jesper Gromada +91 more
TL;DR: It is found that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4−/− mice on a high-fat diet show improved insulin sensitivity.
Journal ArticleDOI
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials
Katherine M. Livingstone,Katherine M. Livingstone,Carlos Celis-Morales,Carlos Celis-Morales,George D. Papandonatos,Bahar Erar,Jose C. Florez,Jose C. Florez,Kathleen A. Jablonski,Cristina Razquin,Cristina Razquin,Amelia Marti,Amelia Marti,Yoriko Heianza,Tao Huang,Tao Huang,Frank M. Sacks,Mathilde Svendstrup,Xuemei Sui,Timothy S. Church,Tiina Jääskeläinen,Tiina Jääskeläinen,Jaana Lindström,Jaakko Tuomilehto,Matti Uusitupa,Tuomo Rankinen,Wim H. M. Saris,Torben Hansen,Oluf Pedersen,Arne Astrup,Thorkild I. A. Sørensen,Lu Qi,Lu Qi,George A. Bray,Miguel Ángel Martínez-González,Miguel Ángel Martínez-González,J. Alfredo Martínez,J. Alfredo Martínez,Paul W. Franks,Paul W. Franks,Jeanne M. McCaffery,Jose Lara,Jose Lara,John C. Mathers +43 more
TL;DR: Findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions.
Journal ArticleDOI
Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program.
Paul W. Franks,Kathleen A. Jablonski,Linda M. Delahanty,Jarred B. McAteer,Jarred B. McAteer,Steven E. Kahn,William C. Knowler,Jose C. Florez,Jose C. Florez +8 more
TL;DR: Within the DPP study population, common variants in FTO and INSIG2 are nominally associated with quantitative measures of obesity, directly and possibly by interacting with metformin or lifestyle intervention.