J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
Insights From Monogenic Diabetes and Glycemic Treatment Goals for Common Types of Diabetes
TL;DR: Intensive glucose control resulting in a mean glycated hemoglobin (HbA1c) level near 7% had discernible and sustained effects on both microvascular2- 4 and macrovascular5 end points.
Journal ArticleDOI
Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration
Jennifer N. Todd,Jeffrey W. Kleinberger,Shylaja Srinivasan,Sherida E. Tollefsen,Lynne L. Levitsky,Lorraine E. Levitt Katz,Jeanie B. Tryggestad,Fida Bacha,Giuseppina Imperatore,Jean M. Lawrence,Catherine Pihoker,Jasmin Divers,Jason Flannick,Dana Dabelea,Jose C. Florez,Toni I. Pollin +15 more
TL;DR: MODY was identified in 2% of youth with clinically diagnosed type 2 diabetes; in 88% (n=68) the specific diagnosis would direct management, and no criterion reliably separated the two groups.
Journal ArticleDOI
Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease
Laura Smyth,Emma H. Dahlström,Anna Syreeni,Katie Kerr,Jill Kilner,Ross Doyle,Eoin P. Brennan,Viji Nair,Damian Fermin,Robert G. Nelson,Helen C. Looker,Christopher Wooster,Darrell Andrews,Kerry Anderson,Gareth J. McKay,Joanne B. Cole,Rany M. Salem,Peter J. Conlon,Matthias Kretzler,Joel N. Hirschhorn,Denise M. Sadlier,Catherine Godson,Jose C. Florez,Carol Forsblom,Alexander P. Maxwell,Per-Henrik Groop,Niina Sandholm,Amy Jayne McKnight +27 more
TL;DR: In this paper , the authors assess differences in blood-derived genome-wide DNA methylation associated with diabetic kidney disease in 1304 carefully characterised individuals with type 1 diabetes and known renal status from two cohorts in the United Kingdom-Republic of Ireland and Finland.
Journal ArticleDOI
139-OR: Large-Scale Sex-Stratified Additive and Recessive GWAS Identifies Novel Large-Effect Variants and Improves Polygenic Prediction for Type 2 Diabetes
TL;DR: The value of non-additive and sex-stratified analyses for both variant discovery and improving polygenic prediction for T2D is demonstrated.
Journal ArticleDOI
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
V Lagou,Reedik Mägi,Hottenga J-J.,H Grallert,Perry Jrb.,Nabila Bouatia-Naji,Letizia Marullo,D Rybin,Rick Jansen,J L Min,Antigone S. Dimas,Anna Ulrich,L Zudina,Jesper R. Gådin,Longda Jiang,Alessia Faggian,Amélie Bonnefond,Amélie Bonnefond,Amélie Bonnefond,João Fadista,Maria G. Stathopoulou,Aaron Isaacs,Sara M. Willems,Pau Navarro,Tomohiro Tanaka,Anne U. Jackson,May E. Montasser,Jeffery R. O'Connell,L.F. Bielak,Rebecca J. Webster,Richa Saxena,Jeanette M. Stafford,Beate St Pourcain,N J Timpson,Perttu Salo,Shin S-Y.,Najaf Amin,Albert V. Smith,Guo Li,Niek Verweij,Anuj Goel,Ian Ford,Johnson Pcd.,Johnson Pcd.,Toby Johnson,Karen Kapur,Gudmar Thorleifsson,Rona J. Strawbridge,Laura J. Rasmussen-Torvik,Tõnu Esko,Evelin Mihailov,Tove Fall,Ross M. Fraser,Anubha Mahajan,Anubha Mahajan,Stavroula Kanoni,Stavroula Kanoni,Vilmantas Giedraitis,Marcus E. Kleber,Günther Silbernagel,Joanne M. Meyer,Martina Müller-Nurasyid,Andrea Ganna,Sarin A-P.,Loic Yengo,Loic Yengo,Loic Yengo,Dmitry Shungin,Jian'an Luan,Momoko Horikoshi,Ping An,Serena Sanna,Yvonne Boettcher,Nigel W. Rayner,Nigel W. Rayner,Ilja M. Nolte,Tatijana Zemunik,Erik P A Van Iperen,Peter Kovacs,Nicholas D. Hastie,Sarah H. Wild,Stela McLachlan,Susan Campbell,Ozren Polasek,Olga D. Carlson,Josephine M. Egan,Wieland Kiess,Gonneke Willemsen,Johanna Kuusisto,Markku Laakso,Maria Dimitriou,Andrew A. Hicks,R. Rauramaa,Stefania Bandinelli,Barbara Thorand,Yongmei Liu,Iva Miljkovic,Lars Lind,Alex S. F. Doney,Markus Perola,Markus Perola,Markus Perola,Aroon D. Hingorani,Mika Kivimäki,Meena Kumari,Meena Kumari,Amanda J. Bennett,Christopher J. Groves,Christian Herder,Heikki A. Koistinen,Leena Kinnunen,Ulf de Faire,Bakker Sjl.,M. I. J. Uusitupa,Palmer Cna.,Joop Jukema,Naveed Sattar,Anneli Pouta,Harold Snieder,Eric Boerwinkle,James S. Pankow,Patrick K.E. Magnusson,Ulrika Krus,Chiara Scapoli,de Geus Ejcn.,de Geus Ejcn.,M Blüher,M Blüher,Wolffenbuttel Bhr.,M. A. Province,Gonçalo R. Abecasis,James B. Meigs,G K Hovingh,Jaana Lindström,James F. Wilson,James F. Wilson,Alan F. Wright,George Dedoussis,Stefan R Bornstein,Schwarz Peh.,Anke Tönjes,Winkelmann Br,Bernhard O. Boehm,Winfried März,Winfried März,A. Metspalu,Jenna Price,Panagiotis Deloukas,Panagiotis Deloukas,Panagiotis Deloukas,A. Körner,A. Körner,Timo A. Lakka,Sirkka Keinänen-Kiukaanniemi,T. Saaristo,Richard N. Bergman,J. Tuomilehto,Nicholas J. Wareham,Claudia Langenberg,Satu Männistö,Paul W. Franks,Caroline Hayward,Veronique Vitart,J Kaprio,Sophie Visvikis-Siest,B. Balkau,David Altshuler,David Altshuler,Igor Rudan,Michael Stumvoll,Harry Campbell,C M van Duijn,C Gieger,Thomas Illig,Luigi Ferrucci,Nancy L. Pedersen,Peter P. Pramstaller,Boehnke M,Timothy M. Frayling,Alan R. Shuldiner,Alan R. Shuldiner,Patricia A. Peyser,Kardia Slr.,Lyle J. Palmer,B.W.J.H. Penninx,Pierre Meneton,T.B. Harris,Gerjan Navis,Harst Pvd.,George Davey Smith,Nita G. Forouhi,Loos Rjf.,Loos Rjf.,Veikko Salomaa,Nicole Soranzo,D.I. Boomsma,Leif Groop,Leif Groop,Tiinamaija Tuomi,Albert Hofman,Albert Hofman,Patricia B. Munroe,Vilmundur Gudnason,David S. Siscovick,Hugh Watkins,C. Lecoeur,C. Lecoeur,Peter Vollenweider,Anders Franco-Cereceda,Per Eriksson,Jarvelin M-R.,Kari Stefansson,Kari Stefansson,Anders Hamsten,Anders Hamsten,George Nicholson,F Karpe,F Karpe,Emmanouil T. Dermitzakis,Cecilia M. Lindgren,Mark I. McCarthy,Philippe Froguel,Philippe Froguel,Philippe Froguel,Marika Kaakinen,Marika Kaakinen,Valeri Lyssenko,Valeri Lyssenko,Richard M. Watanabe,Erik Ingelsson,Erik Ingelsson,Erik Ingelsson,Jose C. Florez,Josée Dupuis,Ins Barroso,Ins Barroso,Ins Barroso,Andrew P. Morris,Inga Prokopenko +238 more
TL;DR: The original version of this article contained an error in Fig 2, in which panels a and b were inadvertently swapped This has now been corrected in the PDF and HTML versions of the Article.