J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Journal ArticleDOI
CUBN Is a Gene Locus for Albuminuria
Carsten A. Böger,Ming-Huei Chen,Adrienne Tin,Matthias Olden,Anna Köttgen,Anna Köttgen,Ian H. de Boer,Christian Fuchsberger,Conall M. O'Seaghdha,Cristian Pattaro,Alexander Teumer,Ching-Ti Liu,Nicole L. Glazer,Man Li,Jeffrey R. O'Connell,Toshiko Tanaka,Toshiko Tanaka,Carmen A. Peralta,Zoltán Kutalik,Zoltán Kutalik,Jian'an Luan,Jing Hua Zhao,Shih-Jen Hwang,Ermeg L. Akylbekova,Holly Kramer,Pim van der Harst,Albert V. Smith,Kurt Lohman,Mariza de Andrade,Caroline Hayward,Barbara Kollerits,Anke Tönjes,Thor Aspelund,Erik Ingelsson,Gudny Eiriksdottir,Lenore J. Launer,Tamara B. Harris,Alan R. Shuldiner,Braxton D. Mitchell,Dan E. Arking,Nora Franceschini,Eric Boerwinkle,Josephine M. Egan,Dena G. Hernandez,Muredach P. Reilly,Raymond R. Townsend,Thomas Lumley,David S. Siscovick,Bruce M. Psaty,Bryan Kestenbaum,Talin Haritunians,Sven Bergmann,Sven Bergmann,Peter Vollenweider,Gérard Waeber,Vincent Mooser,Dawn M. Waterworth,Andrew D. Johnson,Jose C. Florez,Jose C. Florez,James B. Meigs,Xiaoning Lu,Stephen T. Turner,Elizabeth J. Atkinson,Tennille S. Leak,Knut Aasarød,Frank Skorpen,Ann-Christine Syvänen,Thomas Illig,Jens Baumert,Wolfgang Koenig,Bernhard K. Krämer,Olivier Devuyst,Josyf C. Mychaleckyj,Cosetta Minelli,Stephan J. L. Bakker,Lyudmyla Kedenko,Bernhard Paulweber,Stefan Coassin,Karlhans Endlich,Heyo K. Kroemer,Reiner Biffar,Sylvia Stracke,Henry Völzke,Michael Stumvoll,Reedik Mägi,Harry Campbell,Veronique Vitart,Nicholas D. Hastie,Vilmundur Gudnason,Sharon L.R. Kardia,Yongmei Liu,Ozren Polasek,Gary C. Curhan,Florian Kronenberg,Inga Prokopenko,Igor Rudan,Johan Ärnlöv,Stein Hallan,Gerjan Navis,Afshin Parsa,Luigi Ferrucci,Josef Coresh,Michael G. Shlipak,Shelley B. Bull,Andrew D. Paterson,H.-Erich Wichmann,Nicholas J. Wareham,Ruth J. F. Loos,Jerome I. Rotter,Peter P. Pramstaller,L. Adrienne Cupples,Jacques S. Beckmann,Qiong Yang,Iris M. Heid,Rainer Rettig,Albert W. Dreisbach,Murielle Bochud,Caroline S. Fox,Caroline S. Fox,W. H. Linda Kao +120 more
TL;DR: A missense CUBN variant is identified that associates with levels of albuminuria in both the general population and in individuals with diabetes.
Journal ArticleDOI
Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population.
Karol Estrada,Karol Estrada,Ingvild Aukrust,Ingvild Aukrust,Lise Bjørkhaug,Noël P. Burtt,Josep M. Mercader,Humberto García-Ortiz,Alicia Huerta-Chagoya,Hortensia Moreno-Macías,Geoffrey A. Walford,Jason Flannick,Amy L. Williams,Amy L. Williams,María José Gómez-Vázquez,Juan Carlos Fernández-López,Angélica Martínez-Hernández,Silvia Jiménez-Morales,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Córdova,Xavier Soberón,María Elena González-Villalpando,E. Henderson,Lynne R. Wilkens,Loic Le Marchand,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Rosario Rodríguez-Guillén,Laura Riba,Laeya A. Najmi,Suzanne B.R. Jacobs,Timothy Fennell,Stacey Gabriel,Pierre Fontanillas,Craig L. Hanis,Donna M. Lehman,Christopher P. Jenkinson,Hanna E. Abboud,Graeme I. Bell,Maria L. Cortes,Michael Boehnke,Clicerio Gonzalez-Villalpando,Lorena Orozco,Christopher A. Haiman,Teresa Tusie-Luna,Carlos A. Aguilar-Salinas,David Altshuler,Pål R. Njølstad,Jose C. Florez,Jose C. Florez,Daniel G. MacArthur,Daniel G. MacArthur +55 more
TL;DR: A single low-frequency variant in the MODY3-causing gene HNF1A that is associated with type 2 diabetes in Latino populations and may affect protein function is identified and may have implications for screening and therapeutic modification in this population.
Journal ArticleDOI
Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.
Lu Qi,Marilyn C. Cornelis,Peter Kraft,Kristopher J. Stanya,W. H. Linda Kao,James S. Pankow,Josée Dupuis,Josée Dupuis,Jose C. Florez,Jose C. Florez,Caroline S. Fox,Caroline S. Fox,Guillaume Paré,Guillaume Paré,Qi Sun,Cynthia J. Girman,Cathy C. Laurie,Daniel B. Mirel,Teri A. Manolio,Daniel I. Chasman,Eric Boerwinkle,Paul M. Ridker,David J. Hunter,James B. Meigs,Chih-Hao Lee,Rob M. van Dam,Frank B. Hu +26 more
TL;DR: Analysis of genome-wide association scans in nested case-control samples from two prospective cohort studies suggests that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.
Journal ArticleDOI
Prospective functional classification of all possible missense variants in PPARG
Amit R. Majithia,Ben Tsuda,Maura Agostini,Keerthana Gnanapradeepan,Robert H. Rice,Gina M. Peloso,Gina M. Peloso,Kashyap A. Patel,Xiaolan Zhang,Marjoleine F. Broekema,Nick Patterson,Marc Duby,Ted Sharpe,Eric Kalkhoven,Evan D. Rosen,Evan D. Rosen,Inês Barroso,Sian Ellard,Sian Ellard,Sekar Kathiresan,Stephen O'Rahilly,Krishna Chatterjee,Jose C. Florez,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,David B. Savage,David Altshuler +26 more
TL;DR: Saturation mutagenesis and prospective experimental characterization can support immediate diagnostic interpretation of newly discovered missense variants in disease-related genes.
Journal ArticleDOI
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Jennifer Wessel,Audrey Y. Chu,Sara M. Willems,Shuai Wang,Hanieh Yaghootkar,Jennifer A. Brody,Marco Dauriz,Sridharan Raghavan,Leonard Lipovich,Bertha Hidalgo,Keolu Fox,Jennifer E. Huffman,Ping An,Yingchang Lu,Laura J. Rasmussen-Torvik,Niels Grarup,Margaret G. Ehm,Li Li,Abigail S. Baldridge,Alena Stančáková,Ravinder Abrol,Céline Besse,Anne Boland,Jette Bork-Jensen,Myriam Fornage,Daniel F. Freitag,Melissa E. Garcia,Xiuqing Guo,Hara Kazuo,Aaron Isaacs,Johanna Jakobsdottir,Leslie A. Lange,Jill Layton,Man Li,Jing Hua Zhao,Karina Meidtner,Alanna C. Morrison,Mike A. Nalls,Marjolein J. Peters,Maria Sabater-Lleal,Claudia Schurmann,Angela Silveira,Albert V. Smith,Lorraine Southam,Marcus H. Stoiber,Rona J. Strawbridge,Kent D. Taylor,Tibor V. Varga,Kristine H. Allin,Najaf Amin,Jennifer L. Aponte,Tin Aung,Caterina Barbieri,Nathan A. Bihlmeyer,Michael Boehnke,Cristina Bombieri,Donald W. Bowden,Sean M. Burns,Yuning Chen,Yii Deri Chen,Ching-Yu Cheng,Adolfo Correa,Jacek Czajkowski,Abbas Dehghan,Georg Ehret,Gudny Eiriksdottir,Stefan A. Escher,Aliki-Eleni Farmaki,Mattias Frånberg,Giovanni Gambaro,Franco Giulianini,William A. Goddard,Anuj Goel,Omri Gottesman,Megan L. Grove,Stefan Gustafsson,Yang Hai,Göran Hallmans,Jiyoung Heo,Per Hoffmann,Mohammad Kamran Ikram,Richard A. Jensen,Marit E. Jørgensen,Torben Jørgensen,Maria Karaleftheri,Chiea Chuen Khor,Andrea Kirkpatrick,Aldi T. Kraja,Johanna Kuusisto,Ethan M. Lange,I-Te Lee,Wen Jane Lee,Aaron Leong,Jiemin Liao,Chunyu Liu,Yongmei Liu,Cecilia M. Lindgren,Allan Linneberg,Giovanni Malerba,Vasiliki Mamakou,Eirini Marouli,Nisa M. Maruthur,Angela Matchan,Roberta McKean-Cowdin,Olga McLeod,Ginger A. Metcalf,Karen L. Mohlke,Donna M. Muzny,Ioanna Ntalla,Nicholette D. Palmer,Dorota Pasko,Andreas Peter,Nigel W. Rayner,Frida Renström,Kenneth Rice,Cinzia Sala,Bengt Sennblad,Ioannis Serafetinidis,Jennifer A. Smith,Nicole Soranzo,Elizabeth K. Speliotes,Eli A. Stahl,Kathleen Stirrups,Nikos Tentolouris,Anastasia Thanopoulou,Mina Torres,Michela Traglia,Emmanouil Tsafantakis,Sundas Javad,Lisa R. Yanek,Eleni Zengini,Diane M. Becker,Joshua C. Bis,James B. Brown,L. Adrienne Cupples,Torben Hansen,Erik Ingelsson,Andrew J. Karter,Carlos Lorenzo,Rasika A. Mathias,Jill M. Norris,Gina M. Peloso,Wayne Huey-Herng Sheu,Daniela Toniolo,Dhananjay Vaidya,Rohit Varma,Lynne E. Wagenknecht,Heiner Boeing,Erwin P. Bottinger,George Dedoussis,Panos Deloukas,Ele Ferrannini,Oscar H. Franco,Paul W. Franks,Richard A. Gibbs,Vilmundur Gudnason,Anders Hamsten,Tamara B. Harris,Andrew T. Hattersley,Caroline Hayward,Albert Hofman,Jan-Håkan Jansson,Claudia Langenberg,Lenore J. Launer,Daniel Levy,Ben A. Oostra,Christopher J. O'Donnell,Stephen O'Rahilly,Sandosh Padmanabhan,James S. Pankow,Ozren Polasek,Michael A. Province,Stephen S. Rich,Paul M. Ridker,Igor Rudan,Matthias B. Schulze,Blair H. Smith,André G. Uitterlinden,Mark Walker,Hugh Watkins,Tien Yin Wong,Eleftheria Zeggini,Markku Laakso,Ingrid B. Borecki,Daniel I. Chasman,Oluf Pedersen,Bruce M. Psaty,E. Shyong Tai,Cornelia M. van Duijn,Nicholas J. Wareham,Dawn M. Waterworth,Eric Boerwinkle,W. H. Linda Kao,Jose C. Florez,Ruth J. F. Loos,James G. Wilson,Timothy M. Frayling,David S. Siscovick,Josée Dupuis,Jerome I. Rotter,James B. Meigs,Robert A. Scott,Mark O. Goodarzi +202 more
TL;DR: In this article, the role of coding variation on intermediate traits for type 2 diabetes was explored by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls.