J
Jose C. Florez
Researcher at Harvard University
Publications - 414
Citations - 58686
Jose C. Florez is an academic researcher from Harvard University. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 87, co-authored 357 publications receiving 50750 citations. Previous affiliations of Jose C. Florez include George Washington University & University of California, Davis.
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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
Yang Luo,Xinyi Li,Xin Wang,Steven Gazal,Steven Gazal,Josep M. Mercader,Josep M. Mercader,Benjamin M. Neale,Benjamin M. Neale,Jose C. Florez,Jose C. Florez,Adam Auton,Alkes L. Price,Alkes L. Price,Hilary K. Finucane,Soumya Raychaudhuri +15 more
TL;DR: Cov-LDSC is introduced, a method to accurately estimate genetic heritability and its enrichment in both homogenous and admixed populations with summary statistics and in-sample LD estimates, and develops a computationally efficient method to answer two specific questions.
Journal ArticleDOI
Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
Jordi Merino,Kathleen A. Jablonski,Josep M. Mercader,Josep M. Mercader,Steven E. Kahn,Ling Chen,Ling Chen,Maegan Harden,Linda M. Delahanty,Linda M. Delahanty,Maria Rosario G. Araneta,Geoffrey A. Walford,Suzanne B.R. Jacobs,Suzanne B.R. Jacobs,Uzoma N. Ibebuogu,Paul W. Franks,Paul W. Franks,Paul W. Franks,William C. Knowler,Jose C. Florez +19 more
TL;DR: It is confirmed that diabetes preventive interventions improve cardiometabolic risk factors regardless of CAD genetic risk and delivers hypothesis-generating data on the varying benefit of increasing physical activity and improving diet on intermediate cardiovascular risk factors depending on individual CAD geneticrisk profile.
Journal ArticleDOI
Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Belinda K. Cornes,Jennifer A. Brody,Naghmeh Nikpoor,Alanna C. Morrison,Huan Chu Pham Dang,Byung Soo Ahn,Shuai Wang,Marco Dauriz,Joshua I. Barzilay,Josée Dupuis,Jose C. Florez,Jose C. Florez,Josef Coresh,Richard A. Gibbs,W. H. Linda Kao,Ching-Ti Liu,Barbara McKnight,Donna Muzny,Donna Muzny,James S. Pankow,Jeffrey G. Reid,Charles C. White,Andrew D. Johnson,Tien Yin Wong,Tien Yin Wong,Bruce M. Psaty,Eric Boerwinkle,Jerome I. Rotter,David S. Siscovick,Robert Sladek,James B. Meigs +30 more
TL;DR: One variant, chr11:47227430, seems to be functional, with the rare A allele reducing transcription factor FoxA1 binding and FOXA1-dependent transcriptional activity, in human HepG2 hepatoma cells.
Journal ArticleDOI
A roadmap to achieve pharmacological precision medicine in diabetes
Jose C. Florez,Ewan R. Pearson +1 more
TL;DR: In this paper , the authors argue that a more precise approach to treatment choice is necessary to maximise benefit and minimise harm from existing diabetes therapies, and propose a roadmap to achieve precision medicine as standard of care.
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms
Victor Rusu,Eitan Hoch,Josep M. Mercader,Danielle Tenen,Melissa Gymrek,Christina R. Hartigan,Michael DeRan,Marcin von Grotthuss,Pierre Fontanillas,Alexandra Spooner,Gaelen Guzman,Amy Deik,Kerry A. Pierce,Courtney Dennis,Clary B. Clish,Steven A. Carr,Bridget K. Wagner,Monica Schenone,Maggie C.Y. Ng,Brian H. Chen,Federico Centeno-Cruz,Carlos Zerrweck,Lorena Orozco,David M. Altshuler,Stuart L. Schreiber,Jose C. Florez,Suzanne B.R. Jacobs,Eric S. Lander,Daniel Shriner,Jiang Li,Wei-Min Chen,Xiuqing Guo,Jiankang Liu,Suzette J. Bielinski,Lisa R. Yanek,Mike A. Nalls,Mary E. Comeau,Laura J. Rasmussen-Torvik,Richard A. Jensen,Daniel S. Evans,Yan V. Sun,Ping An,Sanjay R. Patel,Yingchang Lu,Jirong Long,Loren L. Armstrong,Lynne E. Wagenknecht,Lingyao Yang,Beverly M. Snively,Nicholette D. Palmer,Poorva Mudgal,Carl D. Langefeld,Keith L. Keene,Barry I. Freedman,Josyf C. Mychaleckyj,Uma Nayak,Leslie J. Raffel,Mark O. Goodarzi,Y. D.I. Chen,Herman A. Taylor,Adolfo Correa,Mario Sims,David Couper,James S. Pankow,Eric Boerwinkle,Adebowale Adeyemo,Ayo P. Doumatey,Guanjie Chen,Rasika A. Mathias,Dhananjay Vaidya,Andrew B. Singleton,Alan B. Zonderman,Robert P. Igo,John R. Sedor,Edmond K. Kabagambe,David S. Siscovick,Barbara McKnight,Kenneth Rice,Yongmei Liu,Wen-Chi Hsueh,Wei Zhao,Lawrence F. Bielak,Aldi T. Kraja,Michael A. Province,Erwin P. Bottinger,Omri Gottesman,Qiuyin Cai,Wei Zheng,William J. Blot,William L. Lowe,Jennifer A. Pacheco,Dana C. Crawford,Elin Grundberg,Stephen S. Rich,M. Geoffrey Hayes,Xiao-Ou Shu,Ruth J. F. Loos,Ingrid B. Borecki,Patricia A. Peyser,Steven R. Cummings,Bruce M. Psaty,Myriam Fornage,Sudha K. Iyengar,Michele K. Evans,Diane M. Becker,W. H. Linda Kao,James G. Wilson,Jerome I. Rotter,Michèle M. Sale,Simin Liu,Charles N. Rotimi,Donald W. Bowden,Alicia Huerta-Chagoya,Humberto García-Ortiz,Hortensia Moreno-Macías,Alisa K. Manning,Lizz Caulkins,Noël P. Burtt,Jason Flannick,Nick Patterson,Carlos A. Aguilar-Salinas,Teresa Tusié-Luna,David Altshuler,Angélica Martínez-Hernández,Francisco Barajas-Olmos,Cecilia Contreras-Cubas,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Xavier Soberón,Clicerio González-Villalpando,María Elena González-Villalpando,Christopher A. Haiman,Lynne R. Wilkens,Loic Le Marchand,Kristine R. Monroe,Laurence N. Kolonel,Olimpia Arellano-Campos,María Luisa Ordóñez-Sánchez,Maribel Rodríguez-Torres,Yayoi Segura-Kato,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Paloma Almeda-Valdes,Maria L. Cortes +149 more